ID Q7ZX00_XENLA Unreviewed; 526 AA.
AC Q7ZX00;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 118.
DE RecName: Full=Importin subunit alpha {ECO:0000256|PIRNR:PIRNR005673};
GN Name=kpna2.S {ECO:0000313|RefSeq:NP_001080433.1,
GN ECO:0000313|RefSeq:XP_018092734.1,
GN ECO:0000313|Xenbase:XB-GENE-979802};
GN Synonyms=imp alpha 3 {ECO:0000313|EMBL:CAD89697.1}, ipoa1
GN {ECO:0000313|RefSeq:NP_001080433.1,
GN ECO:0000313|RefSeq:XP_018092734.1}, kpna2
GN {ECO:0000313|RefSeq:NP_001080433.1, ECO:0000313|RefSeq:XP_018092734.1,
GN ECO:0000313|Xenbase:XB-GENE-979802}, pen {ECO:0000313|EMBL:AAH46373.1,
GN ECO:0000313|RefSeq:NP_001080433.1, ECO:0000313|RefSeq:XP_018092734.1},
GN qip2 {ECO:0000313|RefSeq:XP_018092734.1}, rch1
GN {ECO:0000313|RefSeq:XP_018092734.1}, srp1alpha
GN {ECO:0000313|RefSeq:NP_001080433.1,
GN ECO:0000313|RefSeq:XP_018092734.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAH46373.1};
RN [1] {ECO:0000313|RefSeq:NP_001080433.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAH46373.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000313|EMBL:AAH46373.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:CAD89697.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=15085949; DOI=10.1078/0171-9335-00360;
RA Wischnewski J., Rudt F., Pieler T.;
RT "Signals and receptors for the nuclear transport of TFIIIA in Xenopus
RT oocytes.";
RL Eur. J. Cell Biol. 83:1-12(2004).
RN [4] {ECO:0000313|EMBL:CAD89697.1, ECO:0000313|RefSeq:NP_001080433.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=15146977; DOI=10.1078/0171-9335-00358;
RA Wischnewski J., Rudt F., Pieler T.;
RT "Signals and receptors for the nuclear transport of TFIIIA in Xenopus
RT oocytes.";
RL Eur. J. Cell Biol. 83:55-66(2004).
RN [5] {ECO:0000313|RefSeq:XP_018092734.1}
RP IDENTIFICATION.
RC STRAIN=J_2021 {ECO:0000313|RefSeq:XP_018092734.1};
RC TISSUE=Erythrocytes {ECO:0000313|RefSeq:XP_018092734.1};
RG RefSeq;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the importin alpha family.
CC {ECO:0000256|ARBA:ARBA00010394, ECO:0000256|PIRNR:PIRNR005673}.
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DR EMBL; BC046373; AAH46373.1; -; mRNA.
DR EMBL; AJ557446; CAD89697.1; -; mRNA.
DR RefSeq; NP_001080433.1; NM_001086964.1.
DR RefSeq; XP_018092734.1; XM_018237245.2.
DR STRING; 8355.Q7ZX00; -.
DR PaxDb; 8355-Q7ZX00; -.
DR DNASU; 380125; -.
DR GeneID; 380125; -.
DR KEGG; xla:380125; -.
DR AGR; Xenbase:XB-GENE-979802; -.
DR CTD; 380125; -.
DR Xenbase; XB-GENE-979802; kpna2.S.
DR OMA; IMIKECG; -.
DR OrthoDB; 916229at2759; -.
DR Proteomes; UP000186698; Chromosome 9_10S.
DR Bgee; 380125; Expressed in ovary and 19 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IEA:InterPro.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR Gene3D; 1.20.5.690; Importin-alpha, importin-beta-binding domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR032413; Arm_3.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR002652; Importin-a_IBB.
DR InterPro; IPR036975; Importin-a_IBB_sf.
DR InterPro; IPR024931; Importin_alpha.
DR PANTHER; PTHR23316; IMPORTIN ALPHA; 1.
DR PANTHER; PTHR23316:SF12; IMPORTIN SUBUNIT ALPHA-1; 1.
DR Pfam; PF00514; Arm; 8.
DR Pfam; PF16186; Arm_3; 1.
DR Pfam; PF01749; IBB; 1.
DR PIRSF; PIRSF005673; Importin_alpha; 1.
DR SMART; SM00185; ARM; 8.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50176; ARM_REPEAT; 3.
DR PROSITE; PS51214; IBB; 1.
PE 2: Evidence at transcript level;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR005673};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR005673}.
FT DOMAIN 1..56
FT /note="IBB"
FT /evidence="ECO:0000259|PROSITE:PS51214"
FT REPEAT 116..159
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 159..201
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 332..366
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REGION 1..72
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..48
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 51..72
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 526 AA; 57553 MW; 15115B4E5561E8F5 CRC64;
MSNNENGARL TRFKNKGKDS TEMRRRRIEV NVELRKAKKD DQMLKRRNVS TFPDEPTSPL
QEKNQNGQTS SQWSVEEIVR GVANPSLDIQ LQATQAARKL LSREREPPID RIIKAGLIPK
LVTFLAHSDC SPIQFEAAWA LTNIASGTSD QTKAVVEGGG VPAFISLLAS PHPHISEQAV
WALGNIAGDG SAYRDLVIKH GAVGPLLALL AGPDLSTLAT GYLRNVTWTL SNLCRNKNPA
PPLDAIQQIL PTIVRLLHHD DREVLADTCW AVSYLTDGSN DRIDVVVRTG LVSRIVQLLA
CGELTVVTPC LRTIGNIVTG TDEQTQVVLD AGALSAFTEL LTHHKNNIQK EAAWTLSNIT
AGRQDQIQEV VNCGLIPYLV EILRKGDYKT QKEAIWAVTN YTSGGTIDQI IYLVQCGIIE
PLSNLLSVKD SKTVLVMLDA FTNIFAAADK IGETEKLCLM VEECGGLDRI EALQSHENEQ
VYKASAALIE KYFSAEDGED ESLAPETTAD GYAFQVEGGT HTTFNF
//
