ID Q7ZX38_XENLA Unreviewed; 566 AA.
AC Q7ZX38;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 24-JAN-2024, entry version 83.
DE SubName: Full=LOC398522 protein {ECO:0000313|EMBL:AAH45251.1};
DE Flags: Fragment;
GN Name=LOC398522 {ECO:0000313|EMBL:AAH45251.1};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAH45251.1};
RN [1] {ECO:0000313|EMBL:AAH45251.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000313|EMBL:AAH45251.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; BC045251; AAH45251.1; -; mRNA.
DR AlphaFoldDB; Q7ZX38; -.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd01221; PH_ephexin; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR047271; Ephexin-like.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR047270; PH_ephexin.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR12845; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR12845:SF6; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 19; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF14604; SH3_9; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50002; SH3; 1.
PE 2: Evidence at transcript level;
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 139..323
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 479..540
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 78..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 90..110
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAH45251.1"
SQ SEQUENCE 566 AA; 65210 MW; DD9750990D9D707D CRC64;
SSWLRNKVTE GGGGSAGRPP NEVPQEQSQP PSEERLMRGG RAQKRQSYCE RRQSRFLLNS
ILYQEYSDVA INREIQRQKR EDTAGDEEEV TGSPKSNLSP SSSFRSQRSS RGSTFSLWQD
IPDVRGSGLL NTLTTHERKL QEAKFELVTS EASYVHSLSI AVDHFLNSPE LNECLGAQEK
QWLFSKLPEV KEISERFLMD LEERLEGDIL HFDVCDIVLH HCPELRRVYL PYVTNQAYQE
QTYQRLLQEN SRFRGILSKL EEDQVCQRLP LTSFLILPFQ RIMRLKMLVE NILKHTTPGS
QNEDTASKAF TELKKLVKGC NASVQSMKRT EELIHLNKKI HFESKIFPLI SQSRWLVKHG
ELVELDMQIP NSAGSKFKLC PKPVYLHLFN DCLLLSRRKE LGRFAVFAHA QMMDLKVTDL
SWKLQEVPGE VFHVQLCHEQ KPKHQILLRA QSESEKQRWI SAMCLSSAQS DLDILTDSED
IPQVQCIKGY TAQEHDELTL EKADILRLAA KTSDGWMEVI RLCDGERGWV PATHVEEITN
KNARLRNLRE NKRIKHATSK LERDPP
//
