ID Q80SY9_MOUSE Unreviewed; 1013 AA.
AC Q80SY9;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 171.
DE RecName: Full=Nucleotide-binding oligomerization domain-containing protein 2 {ECO:0000256|ARBA:ARBA00044203};
DE AltName: Full=Caspase recruitment domain-containing protein 15 {ECO:0000256|ARBA:ARBA00044293};
GN Name=Nod2 {ECO:0000313|EMBL:AAN57787.1,
GN ECO:0000313|Ensembl:ENSMUSP00000113773.2,
GN ECO:0000313|MGI:MGI:2429397};
GN Synonyms=Card15 {ECO:0000313|MGI:MGI:2429397};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|EMBL:AAN52477.1};
RN [1] {ECO:0000313|EMBL:AAN52477.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=A/J {ECO:0000313|EMBL:AAN63039.1}, C3H/HeJ
RC {ECO:0000313|EMBL:AAN63035.1}, C57BL/6 {ECO:0000313|EMBL:AAN52477.1},
RC C57BL/6J {ECO:0000313|EMBL:AAN63034.1}, DDY/Jcl
RC {ECO:0000313|EMBL:AAN62471.1}, EL/Suz {ECO:0000313|EMBL:AAN62470.1},
RC VM/Dk {ECO:0000313|EMBL:AAN57789.1}, and YBR/Ei
RC {ECO:0000313|EMBL:AAN57787.1};
RX PubMed=12676561; DOI=10.1016/S0888-7543(03)00027-2;
RA Ogura Y., Saab L., Chen F.F., Benito A., Inohara N., Nunez G.;
RT "Genetic variation and activity of mouse Nod2, a susceptibility gene for
RT Crohn's disease.";
RL Genomics 81:369-377(2003).
RN [2] {ECO:0000313|Ensembl:ENSMUSP00000113773.2, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000113773.2,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000113773.2}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000113773.2};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004187}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004193}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004193}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004124}. Membrane
CC {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004635}. Mitochondrion
CC {ECO:0000256|ARBA:ARBA00004173}.
CC -!- SIMILARITY: Belongs to the NOD1-NOD2 family.
CC {ECO:0000256|ARBA:ARBA00038296}.
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DR EMBL; AY160220; AAN52477.1; -; mRNA.
DR EMBL; AH012069; AAN57787.1; -; Genomic_DNA.
DR EMBL; AY160340; AAN57787.1; JOINED; Genomic_DNA.
DR EMBL; AY160341; AAN57787.1; JOINED; Genomic_DNA.
DR EMBL; AY160342; AAN57787.1; JOINED; Genomic_DNA.
DR EMBL; AY160343; AAN57787.1; JOINED; Genomic_DNA.
DR EMBL; AY160344; AAN57787.1; JOINED; Genomic_DNA.
DR EMBL; AY160345; AAN57787.1; JOINED; Genomic_DNA.
DR EMBL; AY160346; AAN57787.1; JOINED; Genomic_DNA.
DR EMBL; AY160347; AAN57787.1; JOINED; Genomic_DNA.
DR EMBL; AH012071; AAN57789.1; -; Genomic_DNA.
DR EMBL; AY160360; AAN57789.1; JOINED; Genomic_DNA.
DR EMBL; AY160361; AAN57789.1; JOINED; Genomic_DNA.
DR EMBL; AY160363; AAN57789.1; JOINED; Genomic_DNA.
DR EMBL; AY160364; AAN57789.1; JOINED; Genomic_DNA.
DR EMBL; AY160365; AAN57789.1; JOINED; Genomic_DNA.
DR EMBL; AY160366; AAN57789.1; JOINED; Genomic_DNA.
DR EMBL; AY160367; AAN57789.1; JOINED; Genomic_DNA.
DR EMBL; AH012114; AAN62470.1; -; Genomic_DNA.
DR EMBL; AY160561; AAN62470.1; JOINED; Genomic_DNA.
DR EMBL; AY160562; AAN62470.1; JOINED; Genomic_DNA.
DR EMBL; AY160563; AAN62470.1; JOINED; Genomic_DNA.
DR EMBL; AY160564; AAN62470.1; JOINED; Genomic_DNA.
DR EMBL; AY160565; AAN62470.1; JOINED; Genomic_DNA.
DR EMBL; AY160566; AAN62470.1; JOINED; Genomic_DNA.
DR EMBL; AY160567; AAN62470.1; JOINED; Genomic_DNA.
DR EMBL; AH012115; AAN62471.1; -; Genomic_DNA.
DR EMBL; AY160570; AAN62471.1; JOINED; Genomic_DNA.
DR EMBL; AY160571; AAN62471.1; JOINED; Genomic_DNA.
DR EMBL; AY160572; AAN62471.1; JOINED; Genomic_DNA.
DR EMBL; AY160573; AAN62471.1; JOINED; Genomic_DNA.
DR EMBL; AY160574; AAN62471.1; JOINED; Genomic_DNA.
DR EMBL; AY160575; AAN62471.1; JOINED; Genomic_DNA.
DR EMBL; AY160576; AAN62471.1; JOINED; Genomic_DNA.
DR EMBL; AY160577; AAN62471.1; JOINED; Genomic_DNA.
DR EMBL; AH012151; AAN63034.1; -; Genomic_DNA.
DR EMBL; AY160600; AAN63034.1; JOINED; Genomic_DNA.
DR EMBL; AY160601; AAN63034.1; JOINED; Genomic_DNA.
DR EMBL; AY160602; AAN63034.1; JOINED; Genomic_DNA.
DR EMBL; AY160603; AAN63034.1; JOINED; Genomic_DNA.
DR EMBL; AY160604; AAN63034.1; JOINED; Genomic_DNA.
DR EMBL; AY160605; AAN63034.1; JOINED; Genomic_DNA.
DR EMBL; AY160607; AAN63034.1; JOINED; Genomic_DNA.
DR EMBL; AH012152; AAN63035.1; -; Genomic_DNA.
DR EMBL; AY160610; AAN63035.1; JOINED; Genomic_DNA.
DR EMBL; AY160612; AAN63035.1; JOINED; Genomic_DNA.
DR EMBL; AY160613; AAN63035.1; JOINED; Genomic_DNA.
DR EMBL; AY160614; AAN63035.1; JOINED; Genomic_DNA.
DR EMBL; AY160615; AAN63035.1; JOINED; Genomic_DNA.
DR EMBL; AY160616; AAN63035.1; JOINED; Genomic_DNA.
DR EMBL; AY160617; AAN63035.1; JOINED; Genomic_DNA.
DR EMBL; AH012156; AAN63039.1; -; Genomic_DNA.
DR EMBL; AY160650; AAN63039.1; JOINED; Genomic_DNA.
DR EMBL; AY160651; AAN63039.1; JOINED; Genomic_DNA.
DR EMBL; AY160652; AAN63039.1; JOINED; Genomic_DNA.
DR EMBL; AY160653; AAN63039.1; JOINED; Genomic_DNA.
DR EMBL; AY160654; AAN63039.1; JOINED; Genomic_DNA.
DR EMBL; AY160655; AAN63039.1; JOINED; Genomic_DNA.
DR EMBL; AY160656; AAN63039.1; JOINED; Genomic_DNA.
DR EMBL; AY160657; AAN63039.1; JOINED; Genomic_DNA.
DR RefSeq; NP_665856.2; NM_145857.2.
DR Antibodypedia; 28302; 555 antibodies from 37 providers.
DR DNASU; 257632; -.
DR Ensembl; ENSMUST00000118370.8; ENSMUSP00000113773.2; ENSMUSG00000055994.16.
DR GeneID; 257632; -.
DR KEGG; mmu:257632; -.
DR AGR; MGI:2429397; -.
DR CTD; 64127; -.
DR MGI; MGI:2429397; Nod2.
DR VEuPathDB; HostDB:ENSMUSG00000055994; -.
DR GeneTree; ENSGT00940000160934; -.
DR HOGENOM; CLU_011291_0_0_1; -.
DR OrthoDB; 3087860at2759; -.
DR BioGRID-ORCS; 257632; 2 hits in 79 CRISPR screens.
DR Proteomes; UP000000589; Chromosome 8.
DR Bgee; ENSMUSG00000055994; Expressed in granulocyte and 40 other cell types or tissues.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0097367; F:carbohydrate derivative binding; IEA:UniProt.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0032731; P:positive regulation of interleukin-1 beta production; IDA:BHF-UCL.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR GO; GO:0045088; P:regulation of innate immune response; IEA:UniProt.
DR GO; GO:0032495; P:response to muramyl dipeptide; IDA:BHF-UCL.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR001315; CARD.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR018228; DNase_TatD-rel_CS.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR041267; NLRP_HD2.
DR InterPro; IPR041075; NOD2_WH.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR24106; NACHT, LRR AND CARD DOMAINS-CONTAINING; 1.
DR PANTHER; PTHR24106:SF64; NUCLEOTIDE-BINDING OLIGOMERIZATION DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF00619; CARD; 1.
DR Pfam; PF13516; LRR_6; 5.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF17776; NLRC4_HD2; 1.
DR Pfam; PF17779; NOD2_WH; 1.
DR SMART; SM00368; LRR_RI; 8.
DR SUPFAM; SSF47986; DEATH domain; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50209; CARD; 2.
DR PROSITE; PS50837; NACHT; 1.
DR PROSITE; PS01137; TATD_1; 1.
PE 2: Evidence at transcript level;
KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW Autophagy {ECO:0000256|ARBA:ARBA00023006};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 1..82
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT DOMAIN 107..178
FT /note="CARD"
FT /evidence="ECO:0000259|PROSITE:PS50209"
FT DOMAIN 266..402
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
SQ SEQUENCE 1013 AA; 112779 MW; 459CD3CBE6F66375 CRC64;
MCSQEEFQAQ RSQLVALLIS GSLEGFESIL DWLLSWDVLS REDYEGLSLP GQPLSHSARR
LLDTVWNKGV WGCQKLLEAV QEAQANSHTF ELYGSWDTHS LHPTRDLQSH RPAIVRRLYN
HVEAMLELAR EGGFLSQYEC EEIRLPIFTS SQRARRLLDL AAVKANGLAA FLLQHVRELP
APLPLPYEAA ECQKFISKLR TMVLTQSRFL STYDGSENLC LEDIYTENIL ELQTEVGTAG
ALQKSPAILG LEDLFDTHGH LNRDADTILV VGEAGSGKST LLQRLHLLWA TGRSFQEFLF
IFPFSCRQLQ CVAKPLSLRT LLFEHCCWPD VAQDDVFQFL LDHPDRVLLT FDGLDEFKFR
FTDRERHCSP IDPTSVQTLL FNLLQGNLLK NACKVLTSRP DAVSALLRKF VRTELQLKGF
SEEGIQLYLR KHHREPGVAD RLIQLIQATS ALHGLCHLPV FSWMVSRCHR ELLLQNRGFP
TTSTDMYLLI LQHFLLHASP PDSSPLGLGP GLLQSRLSTL LHLGHLALRG LAMSCYVFSA
QQLQAAQVDS DDISLGFLVR AQSSVPGSKA PLEFLHITFQ CFFAAFYLAV SADTSVASLK
HLFSCGRLGS SLLGRLLPNL CIQGSRVKKG SEAALLQKAE PHNLQITAAF LAGLLSQQHR
DLLAACQVSE RVLLQRQARA RSCLAHSLRE HFHSIPPAVP GETKSMHAMP GFIWLIRSLY
EMQEEQLAQE AVRRLDIGHL KLTFCRVGPA ECAALAFVLQ HLQRPVALQL DYNSVGDVGV
EQLRPCLGVC TALYLRDNNI SDRGARTLVE CALRCEQLQK LALFNNKLTD ACACSMAKLL
AHKQNFLSLR VGNNHITAAG AEVLAQGLKS NTSLKFLGFW GNSVGDKGTQ ALAEVVADHQ
NLKWLSLVGN NIGSMGAEAL ALMLEKNKSL EELCLEENHI CDEGVYSLAE GLKRNSTLKF
LKLSNNGITY RGAEALLQAL SRNSAILEVW LRGNTFSLEE IQTLSSRDAR LLL
//
