ID Q80TI9_MOUSE Unreviewed; 342 AA.
AC Q80TI9;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 129.
DE SubName: Full=MKIAA1146 protein {ECO:0000313|EMBL:BAC65738.1};
DE Flags: Fragment;
GN Name=Asb1 {ECO:0000313|MGI:MGI:1929735};
GN Synonyms=mKIAA1146 {ECO:0000313|EMBL:BAC65738.1};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BAC65738.1};
RN [1] {ECO:0000313|EMBL:BAC65738.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Brain {ECO:0000313|EMBL:BAC65738.1};
RX PubMed=12693553; DOI=10.1093/dnares/10.1.35;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S.,
RA Nakajima D., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: II.
RT The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:35-48(2003).
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
CC -!- SIMILARITY: Belongs to the ankyrin SOCS box (ASB) family.
CC {ECO:0000256|ARBA:ARBA00005949}.
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DR EMBL; AK122456; BAC65738.1; -; mRNA.
DR AlphaFoldDB; Q80TI9; -.
DR SwissPalm; Q80TI9; -.
DR MaxQB; Q80TI9; -.
DR AGR; MGI:1929735; -.
DR MGI; MGI:1929735; Asb1.
DR UniPathway; UPA00143; -.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR CDD; cd03720; SOCS_ASB1; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.750.20; SOCS box; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR037331; ASB1_SOCS.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR24173:SF27; ANKYRIN REPEAT AND SOCS BOX PROTEIN 1; 1.
DR PANTHER; PTHR24173; ANKYRIN REPEAT CONTAINING; 1.
DR Pfam; PF00023; Ank; 2.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 5.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 3.
DR PROSITE; PS50225; SOCS; 1.
PE 2: Evidence at transcript level;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 87..116
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 117..149
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 150..182
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 300..342
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:BAC65738.1"
SQ SEQUENCE 342 AA; 38209 MW; F01F449647D99B2E CRC64;
GPSRHGGGRD RPRWTGRPGT RSAGPNLKEW LREQFCDHPL EHCDDTRLHD AAYVGDLQTL
RNLLQEESYR SRINEKSVWC CGWLPCTPLR IAATAGHGNC VDFLIRKGAE VDLVDVKGQT
ALYVAVVNGH LESTEILLEA GADPNGSRHH RSTPVYHASR VGRDDILKAL IRYGADVDVN
HHLTPDTRPP FSRRLTSLVV CPLYISAAYH NLQCFRLLLQ AGANPDFNCN GPVNTQEFYR
GSPGCVMDAV LRHGCEAAFV SLLVEFGANL NLVKWESLGP EARGRRKMDP EALQVFKEAR
SIPRTLLSLC RVAVRRALGK YRLHLVPSLP LPDPIKKFLL YE
//
