GenomeNet

Database: UniProt
Entry: Q811L6
LinkDB: Q811L6
Original site: Q811L6 
ID   MAST4_MOUSE             Reviewed;        2618 AA.
AC   Q811L6; E9QAH7; Q3UVE7; Q62489; Q6ZQE0; Q8BME3;
DT   10-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 3.
DT   01-OCT-2014, entry version 100.
DE   RecName: Full=Microtubule-associated serine/threonine-protein kinase 4;
DE            EC=2.7.11.1;
GN   Name=Mast4 {ECO:0000312|EMBL:AAH42511.1, ECO:0000312|MGI:MGI:1918885};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:BAE23322.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=C57BL/6J {ECO:0000312|EMBL:BAE23322.1};
RC   TISSUE=Bone marrow {ECO:0000269|PubMed:16141072},
RC   Cerebellum {ECO:0000312|EMBL:BAE23322.1}, and Wolffian duct;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
RA   She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
RA   Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
RA   Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
RA   Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
RA   Lindblad-Toh K., Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of
RT   the mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3] {ECO:0000305, ECO:0000312|EMBL:AAH42511.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 346-2618 (ISOFORM 2).
RC   STRAIN=Czech II {ECO:0000312|EMBL:AAH42511.1};
RC   TISSUE=Mammary gland {ECO:0000312|EMBL:AAH42511.1};
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4] {ECO:0000305, ECO:0000312|EMBL:BAC97924.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1671-2618 (ISOFORM 1).
RC   TISSUE=Brain {ECO:0000312|EMBL:BAC97924.1};
RX   PubMed=14621295; DOI=10.1093/dnares/10.4.167;
RA   Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA   Saga Y., Nagase T., Ohara O., Koga H.;
RT   "Prediction of the coding sequences of mouse homologues of KIAA gene:
RT   III. The complete nucleotide sequences of 500 mouse KIAA-homologous
RT   cDNAs identified by screening of terminal sequences of cDNA clones
RT   randomly sampled from size-fractionated libraries.";
RL   DNA Res. 10:167-180(2003).
RN   [5] {ECO:0000305, ECO:0000312|EMBL:CAB01547.1}
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 2398-2498 (ISOFORM 1).
RC   TISSUE=Cochlea {ECO:0000312|EMBL:CAB01547.1};
RX   PubMed=9119401; DOI=10.1006/geno.1996.4526;
RA   Crozet F., El-Amraoui A., Blanchard S., Lenoir M., Ripoll C., Vago P.,
RA   Hamel C., Fizames C., Levi-Acobas F., Depetris D., Mattei M.-G.,
RA   Weil D., Pujol R., Petit C.;
RT   "Cloning of the genes encoding two murine and human cochlear
RT   unconventional type I myosins.";
RL   Genomics 40:332-341(1997).
CC   -!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
CC       {ECO:0000250|UniProtKB:Q60592}.
CC   -!- COFACTOR: Magnesium. {ECO:0000250|UniProtKB:Q60592}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q60592}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1 {ECO:0000269|PubMed:14621295, ECO:0000269|PubMed:16141072,
CC       ECO:0000269|PubMed:9119401};
CC         IsoId=Q811L6-1; Sequence=Displayed;
CC         Note=No experimental confirmation available. {ECO:0000305};
CC       Name=2 {ECO:0000269|PubMed:15489334};
CC         IsoId=Q811L6-2; Sequence=VSP_041616, VSP_052478, VSP_052479,
CC                                  VSP_052480;
CC         Note=No experimental confirmation available. {ECO:0000305};
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. AGC Ser/Thr
CC       protein kinase family. {ECO:0000305}.
CC   -!- SIMILARITY: Contains 1 AGC-kinase C-terminal domain.
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Contains 1 PDZ (DHR) domain. {ECO:0000255|PROSITE-
CC       ProRule:PRU00143}.
CC   -!- SIMILARITY: Contains 1 protein kinase domain.
CC       {ECO:0000255|PROSITE-ProRule:PRU00159}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AK090136; Type=Frameshift; Positions=1682; Evidence={ECO:0000269|PubMed:16141072};
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DR   EMBL; AK032755; BAC28008.1; -; mRNA.
DR   EMBL; AK090136; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AK137360; BAE23322.1; -; mRNA.
DR   EMBL; AC112791; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC114827; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC124387; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC161446; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC165290; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC167975; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC042511; AAH42511.1; -; mRNA.
DR   EMBL; AK129114; BAC97924.1; -; mRNA.
DR   EMBL; Z78145; CAB01547.1; -; mRNA.
DR   CCDS; CCDS49349.1; -. [Q811L6-1]
DR   RefSeq; NP_780380.2; NM_175171.3. [Q811L6-1]
DR   UniGene; Mm.202606; -.
DR   UniGene; Mm.447520; -.
DR   ProteinModelPortal; Q811L6; -.
DR   SMR; Q811L6; 379-479, 1138-1229.
DR   PhosphoSite; Q811L6; -.
DR   PaxDb; Q811L6; -.
DR   PRIDE; Q811L6; -.
DR   Ensembl; ENSMUST00000167058; ENSMUSP00000128464; ENSMUSG00000034751. [Q811L6-1]
DR   GeneID; 328329; -.
DR   KEGG; mmu:328329; -.
DR   UCSC; uc007rsb.2; mouse. [Q811L6-1]
DR   CTD; 375449; -.
DR   MGI; MGI:1918885; Mast4.
DR   eggNOG; COG0515; -.
DR   GeneTree; ENSGT00530000063286; -.
DR   HOGENOM; HOG000046662; -.
DR   HOVERGEN; HBG108118; -.
DR   InParanoid; Q811L6; -.
DR   KO; K08789; -.
DR   OMA; ECLPGNP; -.
DR   TreeFam; TF313149; -.
DR   NextBio; 398238; -.
DR   PRO; PR:Q811L6; -.
DR   ArrayExpress; Q811L6; -.
DR   Bgee; Q811L6; -.
DR   Genevestigator; Q811L6; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR   GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1480.20; -; 1.
DR   Gene3D; 2.30.42.10; -; 1.
DR   InterPro; IPR000961; AGC-kinase_C.
DR   InterPro; IPR011009; Kinase-like_dom.
DR   InterPro; IPR015022; MA_Ser/Thr_Kinase_dom.
DR   InterPro; IPR023142; MAST_pre-PK_dom.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR000719; Prot_kinase_dom.
DR   InterPro; IPR002290; Ser/Thr_dual-sp_kinase_dom.
DR   InterPro; IPR008271; Ser/Thr_kinase_AS.
DR   Pfam; PF08926; DUF1908; 1.
DR   Pfam; PF00595; PDZ; 1.
DR   Pfam; PF00069; Pkinase; 1.
DR   SMART; SM00228; PDZ; 1.
DR   SMART; SM00133; S_TK_X; 1.
DR   SMART; SM00220; S_TKc; 1.
DR   SUPFAM; SSF140482; SSF140482; 1.
DR   SUPFAM; SSF50156; SSF50156; 1.
DR   SUPFAM; SSF56112; SSF56112; 1.
DR   PROSITE; PS51285; AGC_KINASE_CTER; 1.
DR   PROSITE; PS50106; PDZ; 1.
DR   PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR   PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; ATP-binding; Complete proteome; Cytoplasm;
KW   Kinase; Magnesium; Metal-binding; Nucleotide-binding;
KW   Reference proteome; Serine/threonine-protein kinase; Transferase.
FT   CHAIN         1   2618       Microtubule-associated serine/threonine-
FT                                protein kinase 4.
FT                                /FTId=PRO_0000293629.
FT   DOMAIN      568    841       Protein kinase. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00159}.
FT   DOMAIN      842    904       AGC-kinase C-terminal. {ECO:0000255}.
FT   DOMAIN     1139   1227       PDZ. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00143}.
FT   NP_BIND     574    582       ATP. {ECO:0000250|UniProtKB:P28523,
FT                                ECO:0000255|PROSITE-ProRule:PRU00159}.
FT   ACT_SITE    691    691       Proton acceptor.
FT                                {ECO:0000250|UniProtKB:P28523,
FT                                ECO:0000255|PROSITE-ProRule:PRU00159,
FT                                ECO:0000255|PROSITE-ProRule:PRU10027}.
FT   BINDING     597    597       ATP. {ECO:0000250|UniProtKB:P28523,
FT                                ECO:0000255|PROSITE-ProRule:PRU00159}.
FT   VAR_SEQ     350    521       Missing (in isoform 2).
FT                                {ECO:0000303|PubMed:15489334}.
FT                                /FTId=VSP_041616.
FT   VAR_SEQ    1030   1096       Missing (in isoform 2).
FT                                {ECO:0000303|PubMed:15489334}.
FT                                /FTId=VSP_052478.
FT   VAR_SEQ    1263   1282       SLFKKLAKQPSPLLHTSRSF -> DRKKKKKRELSSRCLPS
FT                                SNR (in isoform 2).
FT                                {ECO:0000303|PubMed:15489334}.
FT                                /FTId=VSP_052479.
FT   VAR_SEQ    1283   2618       Missing (in isoform 2).
FT                                {ECO:0000303|PubMed:15489334}.
FT                                /FTId=VSP_052480.
FT   CONFLICT    546    546       M -> T (in Ref. 3; AAH42511).
FT                                {ECO:0000305}.
FT   CONFLICT   1963   1963       A -> T (in Ref. 4; BAC97924).
FT                                {ECO:0000305}.
FT   CONFLICT   1977   1977       K -> I (in Ref. 1; BAC28008).
FT                                {ECO:0000305}.
FT   CONFLICT   2143   2143       S -> G (in Ref. 1; BAC28008).
FT                                {ECO:0000305}.
FT   CONFLICT   2181   2181       A -> ATA (in Ref. 4; BAC97924).
FT                                {ECO:0000305}.
FT   CONFLICT   2444   2444       S -> G (in Ref. 1; BAC28008).
FT                                {ECO:0000305}.
FT   CONFLICT   2507   2507       D -> E (in Ref. 1; BAE23322).
FT                                {ECO:0000305}.
SQ   SEQUENCE   2618 AA;  284004 MW;  493D6B86DA86BA5C CRC64;
     MGEKVSEAPE PVPRGCSGHG ARTLVSSAAA VSSEGASSAE SSSGSETLSE EGEPSRFSCR
     SQPPRPPGGA LGTRLPAAWA PARVALERGV PTLPLPHPGG AVLPVPQVSS ASQEEQDEEL
     DHILSPPPMP FRKCSNPDVA CGLGKSLKYK RQLSEDGKQL RRGSLGGALT GRYLLPNPVA
     GQAWPASAET SNLVRMRSQA LGQSAPSLTA SLKELSLPRR GSLCRTSNRK SLIGNGQSPA
     LPRPHSPLSA HAGNSPQDSP RNFSPSASAH FSFARRTDGR RWSLASLPSS GYGTNTPSST
     VSSSCSSQEK LHQLPYQPTP DELHFLSKHF CTTESIATEN RCRNTPMRPR SRSLSPGRSP
     ACCDHEIIMM NHVYKERFPK ATAQMEERLK EIITSYSPDH VLPLADGVLS FTHHQIIELA
     RDCLDKSHQG LITSRYFFEL QHKLDKLLQE AHDRSESGEL AFIKQLVRKI LIVIARPARL
     LECLEFDPEE FYYLLEAAEG HAKEGQGIKT DIPRYIISQL GLNKDPLEEM AQLGNYDSRT
     AETPEMDESV SSSNTSLRLR RKPRESDFET IKLISNGAYG AVYFVRHKES RQRFAMKKIN
     KQNLILRNQI QQAFVERDIL TFAENPFVVS MYCSFETRRH LCMVMEYVEG GDCATLMKNM
     GPLPVDMARM YFAETVLALE YLHNYGIVHR DLKPDNLLVT SMGHIKLTDF GLSKVGLMSM
     TTNLYEGHIE KDAREFLDKQ VCGTPEYIAP EVILRQGYGK PVDWWAMGII LYEFLVGCVP
     FFGDTPEELF GQVISDEINW PEKDEAPPPD AQELITLLLR QNPLERLGTG GAYEVKQHRF
     FRSLDWNSLL RQKAEFIPQL ESEDDTSYFD TRSEKYHHME TEEEDDTNDE DFTVEIRQFS
     SCSHRFSKVF SSIDRITQNS GEDKDDSEDK TKSTTLPSTE TLSWSSEYSE MQQLSTSNSS
     DTESNRCKLS SGLLPKLAIS TDGEQDEAVP CSGDPREEPE KPVPPSEECT QEEPEVTTPA
     STISSSTLSV GSFSEHLDQI NGRSECVDST DNSSKPSSEP TSHVARQRLE STEKKKISGK
     VTKSLSASAL SLMIPGDMFA VSPLGSPMSP HSLSSDPSSS RDSSPSRDSS AASASPHQPI
     VIHSSGKNYG FTIRAIRVYV GDSDIYTVHH IVWNVEEGSP AYQAGLKAGD LITHINGEPV
     HGLVHTEVIE LLLKSGNKVS ITTTPFENTS IKTGPARRNS YKGRMVRRSK KSKKKESLER
     RRSLFKKLAK QPSPLLHTSR SFSCLNRSLS SGESLPGSPT HSLSPRSPTP SYRSTPDFPS
     GTNSSQSSSP SSSAPNSPAG SGHIRPSTLH GLAPKLSGQR YRSGRRKSAG SIPLSPLART
     PSPTPQPTSP QRSPSPLLGH SLGNAKITQA FPSKMHSPPT IVRHIVRPKS AEPPRSPLLK
     RVQSEEKLSP SYGSDKKLLC SRKHSLEVTQ EEVQREQCQR EVTLQSLEEN VCDAPSLSRA
     RPVEQGCLKR PVSRKVGRQE SVDDLDRDKL KAKVVVKKPE EKHESHQKPH SLGGDSESYA
     LFRLEEREKK VYSKGLERSG HFENTSAELP SVGSLLKDTL HKQASVRASE GVTSDGAACS
     LTPGEHSQSL GDFKRASASG ILHDSVCPIS DRPAPGKVEY SEKASQAKEL LRSEKLDSKL
     ANIDYLRKKM SLDDKDDSHC AILKPKITSS AHECLPGNPI RPMAGQQETP PASENRAFIN
     STHTPQMSAV SFVPLKALAG RVENGGEKAG LAAPESPVRK SPSEYKLEGR SVSCLKPIEG
     TLDIALLSGP HASKTELLSP EPAQSPSPGI NVGPCVPLAL PGSSGKKGDS TSLREPSSAN
     LKVNKSYLLE PRFLPPSRAL QDSLAASGPE PKSKPERKLI HPSARSPATV TESNLQQKEG
     GPATHQDRST DTRNLPGPGQ TLHNVDLPRL CTRAPLPPEG TPAKEKPCLK EPSAKVKSEW
     SAVRDDGHRD PCAKLCPAET GKASDSSKPL PSGGRTQPDF YKQTQTSEKA WAHAKTNHKD
     SQDEVKSLAR EDSASLLYEK EIGRARKGPE PKPEVPATRC PPQPPGIEGE KREKLSAAPS
     LQKQAPKEPD RKEQTSQRPG GSGPQQPPPT KELSNSASWQ HGSSPSHTLK KEPGTKAAAA
     EPSTSLHDTP RSATATTTAI ATTTTTTSAG HSDCSSHKAR PGPDPSPSKS KHQDRSLSSQ
     KLSAGSAKGK EPVTQPLGGS IREGKGGSKG PVDTFSAVLT TQGKASDVLV QGEGRVSIIV
     HTEECPLDAK LKNTNGGCPP EMQAKHPPRQ GHLSEAADQK PLIAGEKQSP SPKHPKPSTV
     KDYPSLCRQT DRSPSHQATT GDRKAEGKKC TDALYVAAPE GYKPEASPSL HHGETGLRGS
     ERPPMGMGKG FSEPKGKGPG PQKSLAETGK PSGMKRSPSA TVQSSLRSAA PPEKSLSYSA
     SFPEAQPGVR EVPAANSSPS SAKATGGTSE FPAPSSRDHR KLQSGGDGRS QMIKSDSLPS
     FRLSTSALES HFQDPQVPIA SGHRGRALSV TAATGEPKGR ELAQPPPVRK QNACREATRA
     PPAPSTDRSL PLSSEKDFVV RQRRGKETLR SSPHKKAS
//
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