ID   Q81A21_BACCR            Unreviewed;       585 AA.
AC   Q81A21;
DT   01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2003, sequence version 1.
DT   27-MAR-2024, entry version 120.
DE   SubName: Full=Pyruvate synthase alpha chain {ECO:0000313|EMBL:AAP10698.1};
DE            EC=1.2.7.1 {ECO:0000313|EMBL:AAP10698.1};
GN   OrderedLocusNames=BC_3774 {ECO:0000313|EMBL:AAP10698.1};
OS   Bacillus cereus (strain ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC
OS   15305 / NCIMB 9373 / NCTC 2599 / NRRL B-3711).
OC   Bacteria; Bacillota; Bacilli; Bacillales; Bacillaceae; Bacillus;
OC   Bacillus cereus group.
OX   NCBI_TaxID=226900 {ECO:0000313|EMBL:AAP10698.1, ECO:0000313|Proteomes:UP000001417};
RN   [1] {ECO:0000313|EMBL:AAP10698.1, ECO:0000313|Proteomes:UP000001417}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 14579 / DSM 31 / CCUG 7414 / JCM 2152 / NBRC 15305 / NCIMB
RC   9373 / NCTC 2599 / NRRL B-3711 {ECO:0000313|Proteomes:UP000001417};
RX   PubMed=12721630; DOI=10.1038/nature01582;
RA   Ivanova N., Sorokin A., Anderson I., Galleron N., Candelon B., Kapatral V.,
RA   Bhattacharyya A., Reznik G., Mikhailova N., Lapidus A., Chu L., Mazur M.,
RA   Goltsman E., Larsen N., D'Souza M., Walunas T., Grechkin Y., Pusch G.,
RA   Haselkorn R., Fonstein M., Ehrlich S.D., Overbeek R., Kyrpides N.;
RT   "Genome sequence of Bacillus cereus and comparative analysis with Bacillus
RT   anthracis.";
RL   Nature 423:87-91(2003).
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DR   EMBL; AE016877; AAP10698.1; -; Genomic_DNA.
DR   RefSeq; NP_833497.1; NC_004722.1.
DR   RefSeq; WP_000625418.1; NZ_CP034551.1.
DR   AlphaFoldDB; Q81A21; -.
DR   MetOSite; Q81A21; -.
DR   KEGG; bce:BC3774; -.
DR   PATRIC; fig|226900.8.peg.3890; -.
DR   HOGENOM; CLU_017038_1_0_9; -.
DR   OrthoDB; 9794954at2; -.
DR   Proteomes; UP000001417; Chromosome.
DR   GO; GO:0019164; F:pyruvate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006979; P:response to oxidative stress; IBA:GO_Central.
DR   CDD; cd07034; TPP_PYR_PFOR_IOR-alpha_like; 1.
DR   Gene3D; 3.40.50.920; -; 1.
DR   Gene3D; 3.40.50.970; -; 1.
DR   Gene3D; 3.40.920.10; Pyruvate-ferredoxin oxidoreductase, PFOR, domain III; 1.
DR   InterPro; IPR022367; 2-oxoacid/accept_OxRdtase_asu.
DR   InterPro; IPR033412; PFOR_II.
DR   InterPro; IPR019752; Pyrv/ketoisovalerate_OxRed_cat.
DR   InterPro; IPR002880; Pyrv_Fd/Flavodoxin_OxRdtase_N.
DR   InterPro; IPR002869; Pyrv_flavodox_OxRed_cen.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR009014; Transketo_C/PFOR_II.
DR   NCBIfam; TIGR03710; OAFO_sf; 1.
DR   PANTHER; PTHR32154:SF20; 2-OXOGLUTARATE OXIDOREDUCTASE SUBUNIT KORA; 1.
DR   PANTHER; PTHR32154; PYRUVATE-FLAVODOXIN OXIDOREDUCTASE-RELATED; 1.
DR   Pfam; PF17147; PFOR_II; 1.
DR   Pfam; PF01558; POR; 1.
DR   Pfam; PF01855; POR_N; 1.
DR   SUPFAM; SSF53323; Pyruvate-ferredoxin oxidoreductase, PFOR, domain III; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
DR   SUPFAM; SSF52922; TK C-terminal domain-like; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:AAP10698.1}; Pyruvate {ECO:0000313|EMBL:AAP10698.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001417}.
FT   DOMAIN          14..174
FT                   /note="Pyruvate/ketoisovalerate oxidoreductase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF01558"
FT   DOMAIN          210..448
FT                   /note="Pyruvate flavodoxin/ferredoxin oxidoreductase
FT                   pyrimidine binding"
FT                   /evidence="ECO:0000259|Pfam:PF01855"
FT   DOMAIN          476..571
FT                   /note="Pyruvate:ferredoxin oxidoreductase core"
FT                   /evidence="ECO:0000259|Pfam:PF17147"
SQ   SEQUENCE   585 AA;  64488 MW;  D006D331E279C9F3 CRC64;
     MISQLSWKVG GQQGEGIEST GEIFCIALNR LGYYLYGYRH FSSRIKGGHT NNKIRVSTTE
     VRAISDDLDI LIAFDQETID FNFHELRPGG IVVADAKFNP TIPDNTDVNL YVIPFTDIAS
     ELGTSLMKNM VAVGASSAVL GLDETAYLDV VEEIFGRKGE QVVQKNMDAI KRGSQYMKEL
     LGEKVNMMQL EKADGKKRMF MIGNDAIAFG AVAGGARFMS AYPITPASEI MEYLIKKLPK
     VGGTVIQTED EIAACTMAIG ANYAGVRTLT ASAGPGLSLM MEAIGLAGIT ETPLVIVDTQ
     RGGPSTGLPT KQEQSDLMAM IYGTHGEIPK IVMAPSTVEE AFYDIVEAFN LSEEYQVPVI
     FLTDLQLSLG KQTVEPLKLD KVEIRRGKLD LEVELPEREN KAYFKRYEVT EDGVSPRVLP
     GMKNGVHHVT GVEHDETGKP SESAINRKDQ MDKRFRKMEN LKFNTPVYKN VKHEEADVLL
     VGFNSTRGAI EEAMTRLEQE GMKVNHAHVR LIHPFPTAEI DPLVKKAKRV VVVENNATGQ
     LANIMKMNLG NGEKISSLLK YDGNPFLPKE IYNECKKGVV LNGNI
//