ID Q824Z0_STRAW Unreviewed; 835 AA.
AC Q824Z0;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 126.
DE SubName: Full=Helicase {ECO:0000313|EMBL:BAC75282.1, ECO:0000313|EMBL:BAU77696.1};
GN Name=ttrA2 {ECO:0000313|EMBL:BAC75282.1};
GN ORFNames=SAVERM_2p257 {ECO:0000313|EMBL:BAU77696.1}, SAVERM_7571
GN {ECO:0000313|EMBL:BAC75282.1};
OS Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC
OS 14893 / NCIMB 12804 / NRRL 8165 / MA-4680).
OG Plasmid SAP2 {ECO:0000313|EMBL:BAU77696.1}.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=227882 {ECO:0000313|EMBL:BAC75282.1, ECO:0000313|Proteomes:UP000000428};
RN [1] {ECO:0000313|EMBL:BAC75282.1, ECO:0000313|Proteomes:UP000000428}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 /
RC NRRL 8165 / MA-4680 {ECO:0000313|Proteomes:UP000000428}, and MA-4680
RC {ECO:0000313|EMBL:BAC75282.1};
RX PubMed=11572948; DOI=10.1073/pnas.211433198;
RA Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M.,
RA Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T.,
RA Sakaki Y., Hattori M.;
RT "Genome sequence of an industrial microorganism Streptomyces avermitilis:
RT deducing the ability of producing secondary metabolites.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001).
RN [2] {ECO:0000313|EMBL:BAC75282.1, ECO:0000313|Proteomes:UP000000428}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 /
RC NRRL 8165 / MA-4680 {ECO:0000313|Proteomes:UP000000428}, and MA-4680
RC {ECO:0000313|EMBL:BAC75282.1};
RX PubMed=12692562; DOI=10.1038/nbt820;
RA Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T.,
RA Sakaki Y., Hattori M., Omura S.;
RT "Complete genome sequence and comparative analysis of the industrial
RT microorganism Streptomyces avermitilis.";
RL Nat. Biotechnol. 21:526-531(2003).
RN [3] {ECO:0000313|EMBL:BAC75282.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=MA-4680 {ECO:0000313|EMBL:BAC75282.1};
RX PubMed=23990133; DOI=10.1007/s10295-013-1327-x;
RA Ikeda H., Shin-ya K., Omura S.;
RT "Genome mining of the Streptomyces avermitilis genome and development of
RT genome-minimized hosts for heterologous expression of biosynthetic gene
RT clusters.";
RL J. Ind. Microbiol. Biotechnol. 41:233-250(2014).
RN [4] {ECO:0000313|EMBL:BAU77696.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=MA-4680 {ECO:0000313|EMBL:BAU77696.1};
RC PLASMID=SAP2 {ECO:0000313|EMBL:BAU77696.1};
RA Ikeda H.;
RT "Complete sequence of the second linear plasmid SAP2 of Streptomyces
RT avermitilis.";
RL Submitted (MAR-2016) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; BA000030; BAC75282.1; -; Genomic_DNA.
DR EMBL; AP017380; BAU77696.1; -; Genomic_DNA.
DR AlphaFoldDB; Q824Z0; -.
DR KEGG; sma:SAVERM_7571; -.
DR eggNOG; COG1111; Bacteria.
DR eggNOG; COG4889; Bacteria.
DR HOGENOM; CLU_009677_1_0_11; -.
DR OrthoDB; 9776021at2; -.
DR Proteomes; UP000000428; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR CDD; cd18785; SF2_C; 1.
DR Gene3D; 6.10.140.530; -; 3.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR005114; Helicase_assoc.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR47396:SF1; ATP-DEPENDENT HELICASE IRC3-RELATED; 1.
DR PANTHER; PTHR47396; TYPE I RESTRICTION ENZYME ECOKI R PROTEIN; 1.
DR Pfam; PF03457; HA; 3.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF04851; ResIII; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000313|EMBL:BAC75282.1};
KW Helicase {ECO:0000313|EMBL:BAC75282.1};
KW Hydrolase {ECO:0000313|EMBL:BAC75282.1};
KW Nucleotide-binding {ECO:0000313|EMBL:BAC75282.1};
KW Plasmid {ECO:0000313|EMBL:BAU77696.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000428}.
FT DOMAIN 27..203
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 269..455
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 451..481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 453..481
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 835 AA; 91978 MW; 1969C6A363D58B65 CRC64;
MAVKELRPHQ REAVDAVLRA LELPARSTVP ERGLRTQVVM ATGAGKTLVA TRSAEELRAG
RVLVLVPSLD LLAQTETAWR EGGRRGPMIG VSSLRGEEAG FPNTTDVQEL VDWVRPFDKV
TVFATYASLG LGTLERAHAA GLPGWDLIVV DEAHRVSGRI GKPWAVVHDN TRIPALRRLY
MTATPRLWQL DEDFEPGAPG ELVASMEDDP DGPFGSRCFT LTLSEAIDRR ICAPYQVVCV
DITDTQLQAA QLLGAEARSE QVRGARLAAL QTALVKASAE EGFRRTLVFH HVVKEAEAFA
AGLPDIAAQL HAADPELYPR AVWVNWLCGE HKPLHRRRVL TEFADGIATD GTVVEKSYLG
SVKVLGEGVD TKNCDSVYFA DVRGSMPDLV QAVGRALRMQ PGEGKTASLV VPVLLGPGET
ADNMLTSRAF GGLAKLLEAL RAHDARVVEQ LAEQQAPSRS KGVQTREISK EQGGSGDGSS
VSVSAKALLK FSTPRDPAAL AAFINLRVLN PEHQHWRRGI EAAVIYAREH GDLKVPFTFH
VPGHTGQETQ AKGWPASLAA FPLGQWIADA RRFYARGDMD ADRVEQLEKL GMVWSHFDVA
WEEGLAAARG WAAEHGHLLA PLDATYQGAK VGIWLKNART AARKAAEIER RRAEGLPVES
SAGALSDERR EQLEEIDASW CPSWPVTWQR CFHLVRMHLD AGEALPTTAG EVLGQGEDLG
RWVRSVRLGW DKLTTVQQWM CEHVLGITPA TEDEKPKPRR TQADKWAMNY EAAKQFYERE
GHLQVPRKHI ERTVGEDQEE REHKLGAWIG NQRSRAATLT PERMEKLSAI GMRWT
//
