ID Q826K7_STRAW Unreviewed; 1517 AA.
AC Q826K7;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 135.
DE SubName: Full=Modular polyketide synthase {ECO:0000313|EMBL:BAC74895.1};
GN Name=pks4 {ECO:0000313|EMBL:BAC74895.1};
GN ORFNames=SAVERM_7184 {ECO:0000313|EMBL:BAC74895.1};
OS Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC
OS 14893 / NCIMB 12804 / NRRL 8165 / MA-4680).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=227882 {ECO:0000313|EMBL:BAC74895.1, ECO:0000313|Proteomes:UP000000428};
RN [1] {ECO:0000313|EMBL:BAC74895.1, ECO:0000313|Proteomes:UP000000428}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 /
RC NRRL 8165 / MA-4680 {ECO:0000313|Proteomes:UP000000428};
RX PubMed=11572948; DOI=10.1073/pnas.211433198;
RA Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M.,
RA Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T.,
RA Sakaki Y., Hattori M.;
RT "Genome sequence of an industrial microorganism Streptomyces avermitilis:
RT deducing the ability of producing secondary metabolites.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001).
RN [2] {ECO:0000313|EMBL:BAC74895.1, ECO:0000313|Proteomes:UP000000428}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 /
RC NRRL 8165 / MA-4680 {ECO:0000313|Proteomes:UP000000428};
RX PubMed=12692562; DOI=10.1038/nbt820;
RA Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T.,
RA Sakaki Y., Hattori M., Omura S.;
RT "Complete genome sequence and comparative analysis of the industrial
RT microorganism Streptomyces avermitilis.";
RL Nat. Biotechnol. 21:526-531(2003).
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DR EMBL; BA000030; BAC74895.1; -; Genomic_DNA.
DR KEGG; sma:SAVERM_7184; -.
DR eggNOG; COG1028; Bacteria.
DR eggNOG; COG3321; Bacteria.
DR HOGENOM; CLU_000022_35_4_11; -.
DR OrthoDB; 9778690at2; -.
DR Proteomes; UP000000428; Chromosome.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR CDD; cd08955; KR_2_FAS_SDR_x; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF00550; PP-binding; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000000428};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 34..461
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1431..1506
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 1517 AA; 164169 MW; 43B0D4C75D48E962 CRC64;
MPDSSVPVEE RLRSALDTVE EQQQTISKLL REKHEPIAVV GIGLRFPGGS NTPDEFAEFL
REGRSGIGPF PTDRFDTDTY VADGSGEDDE PGRIRTIGGG FLDRIDQFDA PFFNISPKEA
QYMDPQQRLL LETAWEALEH ANIDPTPLRR ANGGVYIGAS SIDYALELDS LPYEELDGHL
ASGITFFPLS GRLSYFLGWR GPCMSLDTAC ASSLTALHSA AEGLRRGECD IALAGAVNAL
HHPRIPVIFS AANMLAPDAQ CKTFDESADG YVRAEGCAVA VLKRLSDAQR DGDTVLGLIR
GSAVGQDGDS AGLTVPNGPA QEAVMRAAIQ RASLQPSDIQ YVEAHGTGTP LGDPIEMGAI
SDVFATSHDK ERPLTVGSVK TNLGHMEPVA GLVGVIKTLL QMREQTIFPH LNFTTPSGRI
PWDSYPVTVP TENRPWKADT RRAVVNSFGF GGTIAAVVLE EPPVPEQPAT APAAVQADRT
DSASAVEQHV FTVSAKNHRS LKQLIERYQR HLDDSPSTDL GSLCYTGNVG RAHHPLRLAG
VVGGREDLDA LLKKGLGQIE KRSIAAERAR KTAFLFTGQG SQHAGMGRPL YERFVVFREH
LDECDRLFAP LLGRSIRALV LGEDDDPDAI HQTRFTQPAL FSLEYSLAQL WLSWGARPSV
LIGHSIGEVV AAAVAGLFSL EDAVTLVAAR ARLMQSVSAP GGMAAVPEAA EQVAPLLESY
PDLTMAAVNS PRQCVISGGT DSLAEVSETL RGRGLDVKQL RVSHAFHSPL MAEVLDEFRE
ALKDITFRQP QLTLVSNITG KVARVAEISK PEYWVRHIVE PVNFEAGMRA IERRGRHVFV
EIGPSIALTG LARSCVDAGE HRWLNSLHPK EKQGLTILQA VAKLYSAGVR VDWNGFHDGR
PGRRVDLPLY AFDRKRYWLP NGTGPSAQDE AAGPRSAFLH EPRWVEQPPT ARTVAGPRHV
LVVNRAAQDV TGLVEQAAGQ DVRLSFAADP EQALDVVRAG EPTDVCWFWQ SDDGPVSAES
LRAECEHNYR DLLTLLGLLE QEEGGLARRL WLVTEAAQVL PGDEPGSGAH LAAATLWGFG
HVLLNEYPSY RVTLVDLPAG GGRTAEEMLL GEWLAADTGE FQVAYRDRTG RHVHRLLPSA
FDSPEQPAEP GTAPVRPDRN YLITGGLGAL GLLTAHRLVD EGARYLTLVS RRAEPAADAA
GLWERLRDRA EVTVLRGDVG DSGDVHRIVE SLHAAPQPLG GIVHTAGGLD DAPVAAQTWE
SIDALFSAKV YGSWMLHEAA QGFDELDFFV AYSSAAAVVG GASQSNYAAA NAYLDQLLHW
RAAQNLPALG VNWGPWSEAG MSARLNARHI EALEREGIVF IPPRQALDTM VSLLGEPVTQ
VLAGECDWDR FSAAKPVVNA FYQELVGADG TSSRTLDLDA LLASPDGERV EKITDFIRHR
VADVLHIDDA DDISPYTEFV QLGLDSLVAV ELKNALEAAF RIPLPLTMAF DYPSAAVLGE
FIGKRLEQAR PTAPAGS
//
