ID Q82ND7_STRAW Unreviewed; 950 AA.
AC Q82ND7;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 124.
DE SubName: Full=Metalloprotease, secreted {ECO:0000313|EMBL:BAC69076.1};
GN ORFNames=SAVERM_1366 {ECO:0000313|EMBL:BAC69076.1};
OS Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC
OS 14893 / NCIMB 12804 / NRRL 8165 / MA-4680).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=227882 {ECO:0000313|EMBL:BAC69076.1, ECO:0000313|Proteomes:UP000000428};
RN [1] {ECO:0000313|EMBL:BAC69076.1, ECO:0000313|Proteomes:UP000000428}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 /
RC NRRL 8165 / MA-4680 {ECO:0000313|Proteomes:UP000000428};
RX PubMed=11572948; DOI=10.1073/pnas.211433198;
RA Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M.,
RA Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T.,
RA Sakaki Y., Hattori M.;
RT "Genome sequence of an industrial microorganism Streptomyces avermitilis:
RT deducing the ability of producing secondary metabolites.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001).
RN [2] {ECO:0000313|EMBL:BAC69076.1, ECO:0000313|Proteomes:UP000000428}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 /
RC NRRL 8165 / MA-4680 {ECO:0000313|Proteomes:UP000000428};
RX PubMed=12692562; DOI=10.1038/nbt820;
RA Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T.,
RA Sakaki Y., Hattori M., Omura S.;
RT "Complete genome sequence and comparative analysis of the industrial
RT microorganism Streptomyces avermitilis.";
RL Nat. Biotechnol. 21:526-531(2003).
CC -!- SIMILARITY: Belongs to the peptidase M4 family.
CC {ECO:0000256|ARBA:ARBA00009388}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BA000030; BAC69076.1; -; Genomic_DNA.
DR AlphaFoldDB; Q82ND7; -.
DR KEGG; sma:SAVERM_1366; -.
DR eggNOG; COG3227; Bacteria.
DR HOGENOM; CLU_314212_0_0_11; -.
DR Proteomes; UP000000428; Chromosome.
DR GO; GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd09597; M4_TLP; 1.
DR Gene3D; 3.10.170.10; -; 1.
DR Gene3D; 3.10.450.490; -; 1.
DR Gene3D; 1.10.390.10; Neutral Protease Domain 2; 1.
DR InterPro; IPR011096; FTP_domain.
DR InterPro; IPR023612; Peptidase_M4.
DR InterPro; IPR027268; Peptidase_M4/M1_CTD_sf.
DR InterPro; IPR001570; Peptidase_M4_C_domain.
DR InterPro; IPR013856; Peptidase_M4_domain.
DR PANTHER; PTHR33794; BACILLOLYSIN; 1.
DR PANTHER; PTHR33794:SF1; BACILLOLYSIN; 1.
DR Pfam; PF07504; FTP; 1.
DR Pfam; PF01447; Peptidase_M4; 1.
DR Pfam; PF02868; Peptidase_M4_C; 1.
DR PRINTS; PR00730; THERMOLYSIN.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metalloprotease {ECO:0000256|ARBA:ARBA00023049,
KW ECO:0000313|EMBL:BAC69076.1}; Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000000428};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 112..142
FT /note="FTP"
FT /evidence="ECO:0000259|Pfam:PF07504"
FT DOMAIN 290..451
FT /note="Peptidase M4"
FT /evidence="ECO:0000259|Pfam:PF01447"
FT DOMAIN 455..609
FT /note="Peptidase M4 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02868"
FT REGION 266..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 445
FT /evidence="ECO:0000256|PIRSR:PIRSR623612-1"
FT ACT_SITE 536
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR623612-1"
SQ SEQUENCE 950 AA; 99568 MW; 80ECD1A01C877E9F CRC64;
MGQSRADSKR PTGLSRARRS GISGAAALIG VAALVVSAVP ADAKAGGPVP PPSPGELIPG
QKTATPALVE GLREQAPAAR NAAGAARAYL AAKQDRYRIA DPGRDLEPLG TVTADGQETV
RLRQRYHGIP VLGGQYVVRM EKQDGGRVVT GTSGKYFTGL RTGTTAEVDD ALAVERAVDA
VLARLGAEKF TAYGEDDEGK KDATPLTGTS HGLVVLPTGT GVLARHVTVR GADPARGEPV
LREVYVDAQA GYPVLQYSGI RTFDAPGTTA EGSAASHPAQ EPTEPAPGET GSGVKLDGKP
VELQVTHDDT RAAYVLRDHS RIHNDTADVL ATWDARGKWA SDVVGNWPAD LQEFASPTPA
FGAEATEAGA VDAHWAAGQV YDYYKNKHGR DSLDGRGMSI NSLVGTTDYG QPYVNAFWDG
QKMVYGNGDA EYRPLAAGLD VVGHEMTHGV VDHSADLVYA GQSGAMNEAI ADYFGNAIET
DVHGIAMADP DSGLLGEALC RTRTPRECAV RDLNDGRTTA KSFLGVGFGT DNGGVHLNST
IFSGALWDIR EDVGPTLADK IVYKALTEYL TPLDGFTQGR DAVIAAARAL GTGGKDLTAV
QRAFNAHGIV PNWELALGVD SDLLIERVNT YDSQLGAGGD WWTAATSNEE GSEAYSVWAG
RTDGTGQLKL MSPNDGRYHV NPATDGKTVV WQAHGTSGVD ILARPLAGGP VKTLWHGRSV
GGALDVDGDV VAFAYNNHGG RAGVAYLSLK DPANVVTIGG GTYHRATFPS LSHGKVVYQD
RQRVSAVYET TTRVVDVATG EDKVIQRAAP GASLGPTAVT GDHVYWLLDE IDQNGTTALR
RAGLDGSGIT DLSPETGPES LNVFDLTASE GAVTVDARTP DPAFRNESLA KLWQFSAEGK
GDGVRKSRVS CNRGEQLSAA AASGTQVVWL DATTGISNVV TRTRPSGTCG
//