ID Q82RL8_STRAW Unreviewed; 228 AA.
AC Q82RL8;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 90.
DE SubName: Full=Membrane protein {ECO:0000313|EMBL:BAC67834.1};
GN ORFNames=SAVERM_125 {ECO:0000313|EMBL:BAC67834.1};
OS Streptomyces avermitilis (strain ATCC 31267 / DSM 46492 / JCM 5070 / NBRC
OS 14893 / NCIMB 12804 / NRRL 8165 / MA-4680).
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=227882 {ECO:0000313|EMBL:BAC67834.1, ECO:0000313|Proteomes:UP000000428};
RN [1] {ECO:0000313|EMBL:BAC67834.1, ECO:0000313|Proteomes:UP000000428}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 /
RC NRRL 8165 / MA-4680 {ECO:0000313|Proteomes:UP000000428};
RX PubMed=11572948; DOI=10.1073/pnas.211433198;
RA Omura S., Ikeda H., Ishikawa J., Hanamoto A., Takahashi C., Shinose M.,
RA Takahashi Y., Horikawa H., Nakazawa H., Osonoe T., Kikuchi H., Shiba T.,
RA Sakaki Y., Hattori M.;
RT "Genome sequence of an industrial microorganism Streptomyces avermitilis:
RT deducing the ability of producing secondary metabolites.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:12215-12220(2001).
RN [2] {ECO:0000313|EMBL:BAC67834.1, ECO:0000313|Proteomes:UP000000428}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 31267 / DSM 46492 / JCM 5070 / NBRC 14893 / NCIMB 12804 /
RC NRRL 8165 / MA-4680 {ECO:0000313|Proteomes:UP000000428};
RX PubMed=12692562; DOI=10.1038/nbt820;
RA Ikeda H., Ishikawa J., Hanamoto A., Shinose M., Kikuchi H., Shiba T.,
RA Sakaki Y., Hattori M., Omura S.;
RT "Complete genome sequence and comparative analysis of the industrial
RT microorganism Streptomyces avermitilis.";
RL Nat. Biotechnol. 21:526-531(2003).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU367016};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU367016}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the DedA family. {ECO:0000256|ARBA:ARBA00010792,
CC ECO:0000256|RuleBase:RU367016}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU367016}.
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DR EMBL; BA000030; BAC67834.1; -; Genomic_DNA.
DR AlphaFoldDB; Q82RL8; -.
DR KEGG; sma:SAVERM_125; -.
DR eggNOG; COG0586; Bacteria.
DR HOGENOM; CLU_044208_6_0_11; -.
DR OrthoDB; 9813426at2; -.
DR Proteomes; UP000000428; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR032818; DedA.
DR InterPro; IPR032816; VTT_dom.
DR PANTHER; PTHR30353; INNER MEMBRANE PROTEIN DEDA-RELATED; 1.
DR PANTHER; PTHR30353:SF0; TRANSMEMBRANE PROTEIN; 1.
DR Pfam; PF09335; SNARE_assoc; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|RuleBase:RU367016};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367016};
KW Reference proteome {ECO:0000313|Proteomes:UP000000428};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU367016};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU367016}.
FT TRANSMEM 77..98
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367016"
FT TRANSMEM 194..215
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367016"
FT DOMAIN 52..182
FT /note="VTT"
FT /evidence="ECO:0000259|Pfam:PF09335"
SQ SEQUENCE 228 AA; 23518 MW; BE82031A5B207F19 CRC64;
MRGPAFMTAP LFAASQLAVN VLSAQSLLAA FGVLGVGVVM FAETGLLIGF FLPGDSLLFT
AGLLCTGSGQ HGVKLSLAPL LVAAAVGALA GAQCGYVLGR KAGGALLARS RSVRLREGAQ
RAEELLERYG HAKAIVLARF VPVVRTVLNP MAGALGVPAR TFTVWQVAGG LVWSLGLTLG
GYALGSSIPN VDRYLLPIIA VIVAVSLLPL AAELYRSRRA AKAKEVRG
//
