ID Q82XY9_NITEU Unreviewed; 322 AA.
AC Q82XY9;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 24-JAN-2024, entry version 103.
DE SubName: Full=D-isomer specific 2-hydroxyacid dehydrogenase {ECO:0000313|EMBL:CAD84012.1};
DE EC=1.1.1.29 {ECO:0000313|EMBL:CAD84012.1};
GN Name=hprA {ECO:0000313|EMBL:CAD84012.1};
GN OrderedLocusNames=NE0101 {ECO:0000313|EMBL:CAD84012.1};
OS Nitrosomonas europaea (strain ATCC 19718 / CIP 103999 / KCTC 2705 / NBRC
OS 14298).
OC Bacteria; Pseudomonadota; Betaproteobacteria; Nitrosomonadales;
OC Nitrosomonadaceae; Nitrosomonas.
OX NCBI_TaxID=228410 {ECO:0000313|EMBL:CAD84012.1, ECO:0000313|Proteomes:UP000001416};
RN [1] {ECO:0000313|EMBL:CAD84012.1, ECO:0000313|Proteomes:UP000001416}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 19718 / CIP 103999 / KCTC 2705 / NBRC 14298
RC {ECO:0000313|Proteomes:UP000001416};
RX PubMed=12700255; DOI=10.1128/JB.185.9.2759-2773.2003;
RA Chain P., Lamerdin J., Larimer F., Regala W., Land M., Hauser L.,
RA Hooper A., Klotz M., Norton J., Sayavedra-Soto L., Arciero D., Hommes N.,
RA Whittaker M., Arp D.;
RT "Complete genome sequence of the ammonia-oxidizing bacterium and obligate
RT chemolithoautotroph Nitrosomonas europaea.";
RL J. Bacteriol. 185:2759-2773(2003).
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|RuleBase:RU003719}.
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DR EMBL; AL954747; CAD84012.1; -; Genomic_DNA.
DR RefSeq; WP_011110753.1; NC_004757.1.
DR AlphaFoldDB; Q82XY9; -.
DR STRING; 228410.NE0101; -.
DR KEGG; neu:NE0101; -.
DR eggNOG; COG1052; Bacteria.
DR HOGENOM; CLU_019796_1_3_4; -.
DR OMA; PHIAWAY; -.
DR OrthoDB; 9805416at2; -.
DR PhylomeDB; Q82XY9; -.
DR Proteomes; UP000001416; Chromosome.
DR GO; GO:0008465; F:glycerate dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR CDD; cd12162; 2-Hacid_dh_4; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43761; D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G13630); 1.
DR PANTHER; PTHR43761:SF1; D-ISOMER SPECIFIC 2-HYDROXYACID DEHYDROGENASE FAMILY PROTEIN (AFU_ORTHOLOGUE AFUA_1G13630); 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000256|RuleBase:RU003719};
KW Reference proteome {ECO:0000313|Proteomes:UP000001416}.
FT DOMAIN 27..314
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 108..287
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 322 AA; 35783 MW; 6F719931C91FDB13 CRC64;
MLTVFLDFGS VTRGDIDRTV LEQVVSPWVY HDNTSREQVA ERIREAEIVV SNKTLLDRSA
LDAANKLKLI CVAATGYNNV DLIAAAERNI PVCNVRNYAT GSVAQHVFMF MLNFACRFVE
YQQLIKRGGW QASSYFCPLD FGITELAGKT LGIVGYGELG NAVANIAKAF GMKLLIAEHK
SASTIRPGRT AFDEVIRQTD FITLHCPLSE DTRHLISNRE LNLMKPSAYL INTARSGLID
ETDLLKSLYS KHIAGAAIDV LKEEPPVSGN PLLDYPHPNL IITPHSAWAS VESRQRMLNL
LADNIRNFLH NKPFNQIKDA LA
//