ID Q84FG6_9MOLU Unreviewed; 551 AA.
AC Q84FG6;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 98.
DE RecName: Full=DNA topoisomerase (ATP-hydrolyzing) {ECO:0000256|ARBA:ARBA00012895};
DE EC=5.6.2.2 {ECO:0000256|ARBA:ARBA00012895};
DE Flags: Fragment;
GN Name=gyrB {ECO:0000313|EMBL:AAO43433.1};
OS Williamsoniiplasma somnilux.
OC Bacteria; Mycoplasmatota; Mollicutes; Entomoplasmatales;
OC Williamsoniiplasma.
OX NCBI_TaxID=215578 {ECO:0000313|EMBL:AAO43433.1};
RN [1] {ECO:0000313|EMBL:AAO43433.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PYAN-1 {ECO:0000313|EMBL:AAO43433.1};
RA Knight T.F.Jr., Gasparich G.E.;
RT "Entomoplasma / Mesoplasma Phylogeny.";
RL Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP-dependent breakage, passage and rejoining of double-
CC stranded DNA.; EC=5.6.2.2; Evidence={ECO:0000256|ARBA:ARBA00000185};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
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DR EMBL; AY196996; AAO43433.1; -; Genomic_DNA.
DR AlphaFoldDB; Q84FG6; -.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003918; F:DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity; IEA:UniProtKB-EC.
DR GO; GO:0006265; P:DNA topological change; IEA:InterPro.
DR CDD; cd16928; HATPase_GyrB-like; 1.
DR CDD; cd00822; TopoII_Trans_DNA_gyrase; 1.
DR CDD; cd03366; TOPRIM_TopoIIA_GyrB; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.40.50.670; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR001241; Topo_IIA.
DR InterPro; IPR013760; Topo_IIA-like_dom_sf.
DR InterPro; IPR013759; Topo_IIA_B_C.
DR InterPro; IPR013506; Topo_IIA_bsu_dom2.
DR InterPro; IPR018522; TopoIIA_CS.
DR InterPro; IPR006171; TOPRIM_domain.
DR InterPro; IPR034160; TOPRIM_GyrB.
DR PANTHER; PTHR45866:SF1; DNA GYRASE SUBUNIT B, MITOCHONDRIAL; 1.
DR PANTHER; PTHR45866; DNA GYRASE/TOPOISOMERASE SUBUNIT B; 1.
DR Pfam; PF00204; DNA_gyraseB; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF01751; Toprim; 1.
DR PRINTS; PR00418; TPI2FAMILY.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00433; TOP2c; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR SUPFAM; SSF56719; Type II DNA topoisomerase; 1.
DR PROSITE; PS00177; TOPOISOMERASE_II; 1.
DR PROSITE; PS50880; TOPRIM; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Isomerase {ECO:0000256|ARBA:ARBA00023235};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Topoisomerase {ECO:0000256|ARBA:ARBA00023029}.
FT DOMAIN 396..510
FT /note="Toprim"
FT /evidence="ECO:0000259|PROSITE:PS50880"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAO43433.1"
FT NON_TER 551
FT /evidence="ECO:0000313|EMBL:AAO43433.1"
SQ SEQUENCE 551 AA; 61180 MW; F3D908436EF8AEB9 CRC64;
PGMYIGSTSK SGLHHLVWEI LDNSIDEAMA GAAHEIKVSI TKDGEIIVQD DGRGIPVGIQ
KDSGKSALEL VFTQLHAGGK FDSDSYKISG GLHGVGASVV NALSLYVDVI VERDGKKFHQ
LFSNGGTIQS ELEILSDSSR TGTTVRFKPD PEIFQESVNF DYITIKNKVK QLAYLNKGIK
LNLVDERIDK AVNFHFPNGI LDYVREENET KTKINPNVFY TDGKFEDIEV EVALQYNADY
NENLITFVNN INTHEGGTHE DGLRQSLTRV INRYAEKVVK ANKQPQKFSW DDVKEGVICI
LSIRHTDPQF EGQTKTKLAN PDAKKAVDTI VGDAFEEFLL KSPDDAKAIL DKNTNAQKAR
IAAQRAREET RRKGALDTFS LPGKLADCET KDPTIAELYL VEGDSAGGSA KTGRNRKHQA
ILPLRGKVLN VERVQEARAF TNNEIKSIVT AIGTGIKEDL DLSKIRYGKI VIMTDADVDG
AHIRTLLLTF FYRYMKDLVR NGNIFIAQPP LFKIEAGKKV AYAYSDAELE ELKLGDFSGS
RFTIQRYKGL G
//
