ID IL10_LAMGL Reviewed; 178 AA.
AC Q865X4;
DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 06-MAR-2013, entry version 51.
DE RecName: Full=Interleukin-10;
DE Short=IL-10;
DE AltName: Full=Cytokine synthesis inhibitory factor;
DE Short=CSIF;
DE Flags: Precursor;
GN Name=IL10;
OS Lama glama (Llama).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Tylopoda;
OC Camelidae; Lama.
OX NCBI_TaxID=9844;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Raadan O., Lee S., Yoshida R., Chang K., Ohashi K., Sugimoto C.,
RA Onuma M.;
RT "Cloning and sequence analysis of cytokine cDNAs of llama and camel.";
RL Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Inhibits the synthesis of a number of cytokines,
CC including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by
CC activated macrophages and by helper T-cells (By similarity).
CC -!- SUBUNIT: Homodimer (By similarity).
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the IL-10 family.
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DR EMBL; AB107649; BAC75386.1; -; mRNA.
DR ProteinModelPortal; Q865X4; -.
DR SMR; Q865X4; 24-178.
DR HOVERGEN; HBG004110; -.
DR GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; ISS:UniProtKB.
DR GO; GO:0030889; P:negative regulation of B cell proliferation; ISS:UniProtKB.
DR GO; GO:0002740; P:negative regulation of cytokine secretion involved in immune response; ISS:UniProtKB.
DR GO; GO:0032715; P:negative regulation of interleukin-6 production; ISS:UniProtKB.
DR GO; GO:0051045; P:negative regulation of membrane protein ectodomain proteolysis; ISS:UniProtKB.
DR GO; GO:0002904; P:positive regulation of B cell apoptotic process; ISS:UniProtKB.
DR GO; GO:0050715; P:positive regulation of cytokine secretion; ISS:UniProtKB.
DR GO; GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; ISS:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.
DR GO; GO:0032800; P:receptor biosynthetic process; ISS:UniProtKB.
DR GO; GO:0051384; P:response to glucocorticoid stimulus; ISS:UniProtKB.
DR GO; GO:0002237; P:response to molecule of bacterial origin; ISS:UniProtKB.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR012351; 4_helix_cytokine_core.
DR InterPro; IPR020443; Interleukin-10/19/20/24.
DR InterPro; IPR020423; Interleukin-10_CS.
DR InterPro; IPR000098; Interleukin_10.
DR PANTHER; PTHR11585; PTHR11585; 1.
DR Pfam; PF00726; IL10; 1.
DR PRINTS; PR01294; INTRLEUKIN10.
DR SMART; SM00188; IL10; 1.
DR SUPFAM; SSF47266; 4_helix_cytokine; 1.
DR PROSITE; PS00520; INTERLEUKIN_10; 1.
PE 2: Evidence at transcript level;
KW Cytokine; Disulfide bond; Glycoprotein; Secreted; Signal.
FT SIGNAL 1 18 Potential.
FT CHAIN 19 178 Interleukin-10.
FT /FTId=PRO_0000015361.
FT CARBOHYD 134 134 N-linked (GlcNAc...) (Potential).
FT DISULFID 30 126 By similarity.
FT DISULFID 80 132 By similarity.
SQ SEQUENCE 178 AA; 20471 MW; CB25D68CAEF88333 CRC64;
MPRSALLCCL ILLAGVAASR DQGTQSENSC AHFPASLPHM LRELRAAFGR VKTFFQMKDQ
LDNMLLTRSL LEDFKGYLGC QALSEMIQFY LEEVMPQAEN HGPDIKEHVN SLGEKLKTLR
LRLRRCHRFL PCENKSKAVE QVRGVFSKLQ EKGVYKAMSE FDIFINYIEA YMTMKMKN
//
