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Database: UniProt
Entry: Q865X4
LinkDB: Q865X4
Original site: Q865X4 
ID   IL10_LAMGL              Reviewed;         178 AA.
AC   Q865X4;
DT   12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   01-OCT-2014, entry version 55.
DE   RecName: Full=Interleukin-10;
DE            Short=IL-10;
DE   AltName: Full=Cytokine synthesis inhibitory factor;
DE            Short=CSIF;
DE   Flags: Precursor;
GN   Name=IL10;
OS   Lama glama (Llama).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Tylopoda;
OC   Camelidae; Lama.
OX   NCBI_TaxID=9844;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Raadan O., Lee S., Yoshida R., Chang K., Ohashi K., Sugimoto C.,
RA   Onuma M.;
RT   "Cloning and sequence analysis of cytokine cDNAs of llama and camel.";
RL   Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Inhibits the synthesis of a number of cytokines,
CC       including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by
CC       activated macrophages and by helper T-cells. {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the IL-10 family. {ECO:0000305}.
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DR   EMBL; AB107649; BAC75386.1; -; mRNA.
DR   ProteinModelPortal; Q865X4; -.
DR   SMR; Q865X4; 24-178.
DR   HOVERGEN; HBG004110; -.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006954; P:inflammatory response; ISS:UniProtKB.
DR   GO; GO:0030889; P:negative regulation of B cell proliferation; ISS:UniProtKB.
DR   GO; GO:0002740; P:negative regulation of cytokine secretion involved in immune response; ISS:UniProtKB.
DR   GO; GO:0032715; P:negative regulation of interleukin-6 production; ISS:UniProtKB.
DR   GO; GO:0051045; P:negative regulation of membrane protein ectodomain proteolysis; ISS:UniProtKB.
DR   GO; GO:0002904; P:positive regulation of B cell apoptotic process; ISS:UniProtKB.
DR   GO; GO:0050715; P:positive regulation of cytokine secretion; ISS:UniProtKB.
DR   GO; GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0032800; P:receptor biosynthetic process; ISS:UniProtKB.
DR   GO; GO:0051384; P:response to glucocorticoid; ISS:UniProtKB.
DR   GO; GO:0002237; P:response to molecule of bacterial origin; ISS:UniProtKB.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR012351; 4_helix_cytokine_core.
DR   InterPro; IPR000098; IL-10.
DR   InterPro; IPR020443; IL-10/19/20/24/26_fam.
DR   InterPro; IPR020423; IL-10_CS.
DR   PANTHER; PTHR11585; PTHR11585; 1.
DR   Pfam; PF00726; IL10; 1.
DR   PRINTS; PR01294; INTRLEUKIN10.
DR   SMART; SM00188; IL10; 1.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   PROSITE; PS00520; INTERLEUKIN_10; 1.
PE   2: Evidence at transcript level;
KW   Cytokine; Disulfide bond; Glycoprotein; Secreted; Signal.
FT   SIGNAL        1     18       {ECO:0000255}.
FT   CHAIN        19    178       Interleukin-10.
FT                                /FTId=PRO_0000015361.
FT   CARBOHYD    134    134       N-linked (GlcNAc...). {ECO:0000255}.
FT   DISULFID     30    126       {ECO:0000250}.
FT   DISULFID     80    132       {ECO:0000250}.
SQ   SEQUENCE   178 AA;  20471 MW;  CB25D68CAEF88333 CRC64;
     MPRSALLCCL ILLAGVAASR DQGTQSENSC AHFPASLPHM LRELRAAFGR VKTFFQMKDQ
     LDNMLLTRSL LEDFKGYLGC QALSEMIQFY LEEVMPQAEN HGPDIKEHVN SLGEKLKTLR
     LRLRRCHRFL PCENKSKAVE QVRGVFSKLQ EKGVYKAMSE FDIFINYIEA YMTMKMKN
//
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