ID Q86DU2_TOXGO Unreviewed; 545 AA.
AC Q86DU2; B6KNB4; B9PXA0; S7UMI3; S8GTJ3;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 106.
DE RecName: Full=Importin subunit alpha {ECO:0000256|PIRNR:PIRNR005673};
GN ORFNames=TGRH88_005560 {ECO:0000313|EMBL:KAF4645452.1};
OS Toxoplasma gondii.
OC Eukaryota; Sar; Alveolata; Apicomplexa; Conoidasida; Coccidia;
OC Eucoccidiorida; Eimeriorina; Sarcocystidae; Toxoplasma.
OX NCBI_TaxID=5811 {ECO:0000313|EMBL:AAP31033.1};
RN [1] {ECO:0000313|EMBL:AAP31033.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=15591057; DOI=10.1074/jbc.M410656200;
RA Bhatti M.M., Sullivan W.J.Jr.;
RT "Histone acetylase GCN5 enters the nucleus via importin-alpha in protozoan
RT parasite Toxoplasma gondii.";
RL J. Biol. Chem. 280:5902-5908(2005).
RN [2] {ECO:0000313|EMBL:KAF4645452.1, ECO:0000313|Proteomes:UP000557509}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RH-88 {ECO:0000313|EMBL:KAF4645452.1,
RC ECO:0000313|Proteomes:UP000557509};
RA Lorenzi H.A., Venepally P., Rozenberg A., Sibley D.;
RT "Genome sequence of Toxoplasma gondii RH-88 strain.";
RL Submitted (MAR-2020) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the importin alpha family.
CC {ECO:0000256|ARBA:ARBA00010394, ECO:0000256|PIRNR:PIRNR005673}.
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DR EMBL; AY267540; AAP31033.1; -; mRNA.
DR EMBL; JAAUHK010000188; KAF4645452.1; -; Genomic_DNA.
DR AlphaFoldDB; Q86DU2; -.
DR SMR; Q86DU2; -.
DR VEuPathDB; ToxoDB:TGARI_252290; -.
DR VEuPathDB; ToxoDB:TGCAST_252290; -.
DR VEuPathDB; ToxoDB:TGCOUG_252290B; -.
DR VEuPathDB; ToxoDB:TGDOM2_252290; -.
DR VEuPathDB; ToxoDB:TGFOU_252290; -.
DR VEuPathDB; ToxoDB:TGGT1_252290; -.
DR VEuPathDB; ToxoDB:TGMAS_252290; -.
DR VEuPathDB; ToxoDB:TGME49_252290; -.
DR VEuPathDB; ToxoDB:TGP89_252290; -.
DR VEuPathDB; ToxoDB:TGPRC2_252290; -.
DR VEuPathDB; ToxoDB:TGRH88_005560; -.
DR VEuPathDB; ToxoDB:TGRUB_252290; -.
DR VEuPathDB; ToxoDB:TGVAND_252290; -.
DR VEuPathDB; ToxoDB:TGVEG_252290; -.
DR OMA; GGFHETQ; -.
DR Proteomes; UP000557509; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0061608; F:nuclear import signal receptor activity; IEA:InterPro.
DR GO; GO:0006606; P:protein import into nucleus; IEA:InterPro.
DR Gene3D; 1.20.5.690; Importin-alpha, importin-beta-binding domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR032413; Arm_3.
DR InterPro; IPR000225; Armadillo.
DR InterPro; IPR002652; Importin-a_IBB.
DR InterPro; IPR036975; Importin-a_IBB_sf.
DR InterPro; IPR024931; Importin_alpha.
DR PANTHER; PTHR23316; IMPORTIN ALPHA; 1.
DR PANTHER; PTHR23316:SF71; IMPORTIN SUBUNIT ALPHA; 1.
DR Pfam; PF00514; Arm; 8.
DR Pfam; PF16186; Arm_3; 1.
DR Pfam; PF01749; IBB; 1.
DR PIRSF; PIRSF005673; Importin_alpha; 1.
DR SMART; SM00185; ARM; 8.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR PROSITE; PS50176; ARM_REPEAT; 5.
DR PROSITE; PS51214; IBB; 1.
PE 2: Evidence at transcript level;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR005673};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR005673}.
FT DOMAIN 1..52
FT /note="IBB"
FT /evidence="ECO:0000259|PROSITE:PS51214"
FT REPEAT 127..170
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 170..212
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 212..241
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 339..381
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REPEAT 381..416
FT /note="ARM"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00259"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 545 AA; 59360 MW; 9860A5E16997ADF9 CRC64;
MERKLADRRS NFKKNFEDPR RKREDLQLQI RKTHREQNLA KKRAEALDAQ DGRLGGDAML
GVGGAAGGGS APGVAGQENV FSFEHLPQMM AMLSSGDPQQ EFEATEQFRR ALSIESRPPI
QEVIEAGAVP LFVQFLKRSD QPRMQFEAAW ALTNIASGTQ EQTQVVIEHG AVPIFVELLS
SPTEDVREQA VWALGNIAGD SPQCRDLVLQ AGVLSPLLAQ LNDSEAKFTM QRNATWTLSN
LCRGKPQPPF EWVQPALTTL AKLIYSTDTE VLTDACWALS YISDGPNERI EAVIEAGVSR
RLVELLGHKS TLVQTPALRT VGNIVTGDDR QTEVVILCGA VPALLMLLSS PKKAIRKEAC
WTISNITAGN RDQIQQVIDA GLIHPLIELL STADFDVRKE AAWAISNAAS GGSNAQVEAL
VECGCIKPLC SLLAVQDSKI VSVALEALEN ILRVGKVKKE QQQLAENPFC ELIEQADGIT
VIEKLQDCAN QDIYEKAWRI ICNYFSFEEA DVDDVDVDGG VGMADAGQVN AFGAAPPQGG
FNFGQ
//
