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Database: UniProt
Entry: Q86G45_CAEEL
LinkDB: Q86G45_CAEEL
Original site: Q86G45_CAEEL 
ID   Q86G45_CAEEL            Unreviewed;      2027 AA.
AC   Q86G45; Q8MPY6;
DT   01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2003, sequence version 1.
DT   27-SEP-2017, entry version 135.
DE   SubName: Full=High voltage activated calcium channel alpha-1 subunit {ECO:0000313|EMBL:AAP13107.1};
GN   Name=unc-2 {ECO:0000313|EMBL:CCD74385.1,
GN   ECO:0000313|WormBase:T02C5.5b};
GN   ORFNames=CELE_T02C5.5 {ECO:0000313|EMBL:CCD74385.1}, T02C5.5
GN   {ECO:0000313|WormBase:T02C5.5b};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000313|EMBL:AAP13107.1};
RN   [1] {ECO:0000313|EMBL:CCD74385.1, ECO:0000313|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD74385.1,
RC   ECO:0000313|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=https://doi.org/10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RA   Sulson J.E., Waterston R.;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
RN   [2] {ECO:0000313|EMBL:AAP13107.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=12878695;
RA   Mathews E.A., Garcia E., Santi C.M., Mullen G.P., Thacker C.,
RA   Moerman D.G., Snutch T.P.;
RT   "Critical residues of the Caenorhabditis elegans unc-2 voltage-gated
RT   calcium channel that affect behavioral and physiological properties.";
RL   J. Neurosci. 23:6537-6545(2003).
RN   [3] {ECO:0000313|EMBL:AAP13107.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Mathews E., Thacker C., Snutch T.;
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:CCD74385.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD74385.1};
RA   Alber B.E., Fuchs G.;
RL   Submitted (MAR-2003) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|EMBL:CCD74385.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Bristol N2 {ECO:0000313|EMBL:CCD74385.1};
RG   WormBase Consortium;
RA   WormBase;
RL   Submitted (MAY-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; AY264781; AAP13107.1; -; mRNA.
DR   EMBL; BX284606; CCD74385.1; -; Genomic_DNA.
DR   RefSeq; NP_741732.2; NM_171638.2.
DR   UniGene; Cel.235; -.
DR   EnsemblMetazoa; T02C5.5b; T02C5.5b; WBGene00006742.
DR   GeneID; 180570; -.
DR   UCSC; T02C5.5d.3; c. elegans.
DR   CTD; 180570; -.
DR   WormBase; T02C5.5b; CE34980; WBGene00006742; unc-2.
DR   eggNOG; ENOG410INF8; Eukaryota.
DR   eggNOG; COG1226; LUCA.
DR   GeneTree; ENSGT00830000128247; -.
DR   HOGENOM; HOG000231529; -.
DR   Reactome; R-CEL-422356; Regulation of insulin secretion.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00006742; -.
DR   GO; GO:0048787; C:presynaptic active zone membrane; IDA:WormBase.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; ISS:WormBase.
DR   GO; GO:0070588; P:calcium ion transmembrane transport; ISS:WormBase.
DR   GO; GO:0035545; P:determination of left/right asymmetry in nervous system; IMP:WormBase.
DR   GO; GO:0007626; P:locomotory behavior; IMP:WormBase.
DR   GO; GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IGI:WormBase.
DR   GO; GO:0001505; P:regulation of neurotransmitter levels; IMP:WormBase.
DR   GO; GO:0009408; P:response to heat; IMP:WormBase.
DR   GO; GO:0042594; P:response to starvation; IMP:WormBase.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   SMART; SM01062; Ca_chan_IQ; 1.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   2: Evidence at transcript level;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000001940};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001940};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM    107    127       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    149    169       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    181    198       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    248    270       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    331    352       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    364    386       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    524    545       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    557    576       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    649    671       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    728    750       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    989   1011       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1102   1128       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1184   1202       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1214   1237       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1249   1270       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1306   1333       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1399   1422       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1438   1473       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      442    481       {ECO:0000256|SAM:Coils}.
FT   COILED      755    785       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2027 AA;  231454 MW;  FB79822A0FBDD297 CRC64;
     MIPIAASEII PSPIHPRKIS INDRLFEIRT PRPGEMIKEA VQMAVWPALP RLAAEEARRE
     QKAESGTFVR KTTLSSNAPV KEKGPSSLFI FAEDNIIRRN AKAIIEWGPF EYFILLTIIG
     NCVVLSMEQH LPKNDKKALS EWLERTEPYF MGIFCLECVL KVIAFGFALH KGSYLRSGWN
     IMDFIVVVSG VVTMLPFSPA TQTANQPVDS VDLRTLRAVR VLRPLKLVSG IPSLQVVLKS
     ILCAMAPLLQ IGLLVLFAII IFAIIGLEFY SGAFHSACYN ERGEIENVSE RPMPCTNKTS
     PMGVYNCDVK GTTCLQKWIG PNYGITSFDN IGFAMITVFQ CITMEGWTTV MYYTNDSLGS
     TYNWAYFIPL IVLGSFFMLN LVLGVLSGEF AKERERVENR REFLKLRRQQ QIERELNGYL
     EWILTAEEVI LKEDRTTEEE KAAIMEARRR AANKKLKQAS KQQSTETEED FEEDEDEMEE
     EYVDEGGTVE DEFAERKKRG CCHSVGKFIK QLRIQIRIMV KTQIFYWSVI TLVFLNTCCV
     ASEHYGQPQW FTDFLKYAEF VFLGIFVVEM LLKLFAMGSR TYFASKFNRF DCVVIVGSAA
     EVIWAEVYGG SFGISVMRAL RLLRIFKLTS YWVSLRNLVR SLMNSMRSII SLLFLLFLFI
     LIFALLGMQL FGGRFNFPTM HPYTHFDTFP VALITVFQIL TGEDWNEVMY LAIESQGGIY
     SGGWPYSIYF IVLVLFGNYT LLNVFLAIAV DNLANAQELT AAEEADEKAN EIEEESEELD
     EQYQEGDHCT IDMEGKTAGD MCAVARAMDD LDEECEEEES PFGGPKPMVP YSSMFFLSPT
     NPFRVLIHSI VCTKYFEMMV MTVICLSSVS LAAEDPVDEE NPRNKVLQYM DYCFTGVFAC
     EMLLKLIDQG ILLHPGSYCR DFWNILDGIV VTCALFAFGF AGTEGSAGKN LNTIKSLRVL
     RVLRPLKTIK RIPKLKAVFD CVVNSLKNVF NILIVYFLFQ FIFAVIAVQL FNGKFFFCTD
     KNRKFANTCH GQFFVYDNQN DPPRVEQREW RLRPFNYDNT INAMLTLFVV TTGEGWPGIR
     QNSMDTTFED QGPSPFFRVE VALFYVMFFI VFPFFFVNIF VALIIITFQE QGEAELSEGD
     LDKNQKQCID FALNARPRSL FMPEDKNSTK YRIWRLVTSP PFEYFIMTMI CCNTLILMMK
     YYNNPLFYEE ILRLFNTALT AVFTVESILK ILAFGVRNYF RDGWNRFDFV TVVGSITDAL
     VTEFGGHFVS LGFLRLFRAA RLIRLLQQGY TIRILLWTFV QSFKALPYVC LLIGMLFFIY
     AIVGMQVFGN IWLNAATEIN RHNNFQSFFN AVILLFRCAT GEGWQDIMMA AVQGKDCARA
     GSAEINFEKG QTCGSNVSYA YFTSFVFLSS FLMLNLFVAV IMDNFDYLTR DSSILGPHHL
     DEFIRVWADY DPAATGRIHY SEMYEMLRIM APPVGFGKKC PYRLAYKHLI RMNMPVAEDG
     TVHFTTTLFA LIRESLSIKM RPVEEMDEAD EELRLTLKKI WPLKAKKNMV DLVVPPNHEL
     CFQKLTVGKI YAGLLILENY RARKSGTEVG GQGLFGGGLR SLVAAAKAAE SQHSSHTPQP
     PEETTPIIPQ HAQQFSAAPT MSAQGSLQQM QGTSSGGGQR PYSLFNSFVD TIKSGKQDGD
     VTDVQYQSVD QQHEKMNSTG RRLSDMFSKI RRGTSADHNP HQTEHLLAQD NRSPSSPRYR
     SMARASPPSP AERYGHPPRY RTESPPSSRS EYQMSIRDPI IRRNRYNTME HSRSSHDPQY
     HQDQQQQQQP HHQQHSQHLQ HSHHKTYQNH NQYSRSPIYS DDSSVAESYR REREFRRYQD
     STPQDVSEDD DPMPTAVRAR RLPLISTMPT HYESAYQPSS YNQHLNDSYG LGTGYQRDYH
     TSHSHSHHPT SQQQQHQPMY STSPLISPRS SHSYYTPRSS QYYEIPSPSP DIYPSYRGSA
     SPRRYPTSTV VVAPDREGSS ARVIQAQPGS IPLSDSETED DPRWAIV
//
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