ID Q86PG6_9MUSC Unreviewed; 625 AA.
AC Q86PG6;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Xanthine dehydrogenase {ECO:0000313|EMBL:AAO26037.1};
DE Flags: Fragment;
GN Name=Xdh {ECO:0000313|FlyBase:FBgn0042042};
GN Synonyms=xdh {ECO:0000313|EMBL:AAO26037.1};
OS Drosophila koepferae.
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila.
OX NCBI_TaxID=41375 {ECO:0000313|EMBL:AAO26037.1};
RN [1] {ECO:0000313|EMBL:AAO26037.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=14595098; DOI=10.1093/molbev/msh006;
RA Piccinali R., Aguade M., Hasson E.;
RT "Comparative molecular population genetics of the Xdh locus in the
RT cactophilic sibling species Drosophila buzzatii and D. koepferae.";
RL Mol. Biol. Evol. 21:141-152(2004).
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
CC -!- SUBCELLULAR LOCATION: Peroxisome {ECO:0000256|ARBA:ARBA00004275}.
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DR EMBL; AY219202; AAO26037.1; -; Genomic_DNA.
DR FlyBase; FBgn0042042; Dkoe\Xdh.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0071949; F:FAD binding; IEA:InterPro.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 3.30.465.10; -; 1.
DR Gene3D; 1.10.150.120; [2Fe-2S]-binding domain; 1.
DR Gene3D; 3.90.1170.50; Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead; 1.
DR Gene3D; 3.30.365.10; Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain; 1.
DR Gene3D; 3.30.390.50; CO dehydrogenase flavoprotein, C-terminal domain; 1.
DR Gene3D; 3.30.43.10; Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase, domain 2; 1.
DR InterPro; IPR002888; 2Fe-2S-bd.
DR InterPro; IPR036884; 2Fe-2S-bd_dom_sf.
DR InterPro; IPR000674; Ald_Oxase/Xan_DH_a/b.
DR InterPro; IPR036856; Ald_Oxase/Xan_DH_a/b_sf.
DR InterPro; IPR016208; Ald_Oxase/xanthine_DH-like.
DR InterPro; IPR037165; AldOxase/xan_DH_Mopterin-bd_sf.
DR InterPro; IPR005107; CO_DH_flav_C.
DR InterPro; IPR036683; CO_DH_flav_C_dom_sf.
DR InterPro; IPR016166; FAD-bd_PCMH.
DR InterPro; IPR036318; FAD-bd_PCMH-like_sf.
DR InterPro; IPR016167; FAD-bd_PCMH_sub1.
DR InterPro; IPR016169; FAD-bd_PCMH_sub2.
DR InterPro; IPR002346; Mopterin_DH_FAD-bd.
DR PANTHER; PTHR11908; XANTHINE DEHYDROGENASE; 1.
DR PANTHER; PTHR11908:SF100; XANTHINE DEHYDROGENASE; 1.
DR Pfam; PF01315; Ald_Xan_dh_C; 1.
DR Pfam; PF03450; CO_deh_flav_C; 1.
DR Pfam; PF00941; FAD_binding_5; 1.
DR Pfam; PF01799; Fer2_2; 1.
DR SMART; SM01008; Ald_Xan_dh_C; 1.
DR SMART; SM01092; CO_deh_flav_C; 1.
DR SUPFAM; SSF55447; CO dehydrogenase flavoprotein C-terminal domain-like; 1.
DR SUPFAM; SSF47741; CO dehydrogenase ISP C-domain like; 1.
DR SUPFAM; SSF54665; CO dehydrogenase molybdoprotein N-domain-like; 1.
DR SUPFAM; SSF56176; FAD-binding/transporter-associated domain-like; 1.
DR SUPFAM; SSF56003; Molybdenum cofactor-binding domain; 1.
DR PROSITE; PS51387; FAD_PCMH; 1.
PE 4: Predicted;
KW 2Fe-2S {ECO:0000256|ARBA:ARBA00022714};
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140}.
FT DOMAIN 110..296
FT /note="FAD-binding PCMH-type"
FT /evidence="ECO:0000259|PROSITE:PS51387"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:AAO26037.1"
FT NON_TER 625
FT /evidence="ECO:0000313|EMBL:AAO26037.1"
SQ SEQUENCE 625 AA; 69120 MW; CACD4465100466F8 CRC64;
GIVMSMYALL RNAXKPSMRD LEVAFQGNLC RCTGYRPILE GYKTFTKEFA CGMGDKCCKV
SGKECGGGVN NTDDELFKSS EFQPFDPSQE PIFPPELQLT AVYDEESLVF RSDRVAWYRP
TRLEELLQLK ADHPEAKLIV GNTEVGVEVK FKHFLYPVLI NPVKVPELLE VCETEDSIYF
GAAVSLMDID AYLRKRIEVL PETQTRLFQC TVDMLHYFAG KQIRNVACLG GNIMTGSPIS
DMNTVLTAAG VRLDVASRAG GRRSVHMGTG FFTGYRRNII EDHETLLGIH FQKTTPDXHM
VAFKQARRRD DDITIVNSTV NVNFKPGTNV VKSIAIAFGG MAPTTVLAPN TSKLMVGQPW
NQALVERVAE SLCQELPLSA SAPGGMIAYR RALVVSLFFK SYLAISRKLC DAGIXPPBAV
PQKDLSGADK FHTPTMRSSQ LFERVASNQA THDPIGKPKV HVSALKQATG EAIYTDDIPR
MDGELYLAFV LSTKAHAKIT KLDASEALAL EGVEAFFSAQ DLTEHQNEVG PVFHDEYVFA
NGEVHCYGQI IGAIAAANQT LAQRAARLVR VEYLELQPVI VTIEQAIEHK SYFPDYPRFL
TKGDVEKAFA EADHVYESSC RMGGQ
//
