ID POTED_HUMAN Reviewed; 584 AA.
AC Q86YR6; C9JCF7;
DT 22-AUG-2003, integrated into UniProtKB/Swiss-Prot.
DT 24-NOV-2009, sequence version 2.
DT 24-JAN-2024, entry version 164.
DE RecName: Full=POTE ankyrin domain family member D;
DE AltName: Full=ANKRD26-like family B member 3;
DE AltName: Full=Ankyrin repeat domain-containing protein 21;
DE AltName: Full=Prostate, ovary, testis-expressed protein;
DE Short=Protein POTE;
GN Name=POTED; Synonyms=A26B3, ANKRD21, POTE;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION, AND
RP VARIANTS SER-113 AND VAL-135.
RC TISSUE=Prostate;
RX PubMed=12475935; DOI=10.1073/pnas.262655399;
RA Bera T.K., Zimonjic D.B., Popescu N.C., Sathyanarayana B.K., Kumar V.,
RA Lee B., Pastan I.;
RT "POTE, a highly homologous gene family located on numerous chromosomes and
RT expressed in prostate, ovary, testis, placenta, and prostate cancer.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:16975-16980(2002).
RN [2]
RP ERRATUM OF PUBMED:12475935.
RA Bera T.K., Zimonjic D.B., Popescu N.C., Sathyanarayana B.K., Kumar V.,
RA Lee B., Pastan I.;
RL Proc. Natl. Acad. Sci. U.S.A. 100:1462-1462(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=10830953; DOI=10.1038/35012518;
RA Hattori M., Fujiyama A., Taylor T.D., Watanabe H., Yada T., Park H.-S.,
RA Toyoda A., Ishii K., Totoki Y., Choi D.-K., Groner Y., Soeda E., Ohki M.,
RA Takagi T., Sakaki Y., Taudien S., Blechschmidt K., Polley A., Menzel U.,
RA Delabar J., Kumpf K., Lehmann R., Patterson D., Reichwald K., Rump A.,
RA Schillhabel M., Schudy A., Zimmermann W., Rosenthal A., Kudoh J.,
RA Shibuya K., Kawasaki K., Asakawa S., Shintani A., Sasaki T., Nagamine K.,
RA Mitsuyama S., Antonarakis S.E., Minoshima S., Shimizu N., Nordsiek G.,
RA Hornischer K., Brandt P., Scharfe M., Schoen O., Desario A., Reichelt J.,
RA Kauer G., Bloecker H., Ramser J., Beck A., Klages S., Hennig S.,
RA Riesselmann L., Dagand E., Wehrmeyer S., Borzym K., Gardiner K.,
RA Nizetic D., Francis F., Lehrach H., Reinhardt R., Yaspo M.-L.;
RT "The DNA sequence of human chromosome 21.";
RL Nature 405:311-319(2000).
RN [4]
RP SUBCELLULAR LOCATION.
RX PubMed=15276201; DOI=10.1016/j.gene.2004.05.009;
RA Bera T.K., Huynh N., Maeda H., Sathyanarayana B.K., Lee B., Pastan I.;
RT "Five POTE paralogs and their splice variants are expressed in human
RT prostate and encode proteins of different lengths.";
RL Gene 337:45-53(2004).
RN [5]
RP VARIANT GLN-172.
RX PubMed=21248752; DOI=10.1038/nature09639;
RA Varela I., Tarpey P., Raine K., Huang D., Ong C.K., Stephens P., Davies H.,
RA Jones D., Lin M.L., Teague J., Bignell G., Butler A., Cho J.,
RA Dalgliesh G.L., Galappaththige D., Greenman C., Hardy C., Jia M.,
RA Latimer C., Lau K.W., Marshall J., McLaren S., Menzies A., Mudie L.,
RA Stebbings L., Largaespada D.A., Wessels L.F.A., Richard S., Kahnoski R.J.,
RA Anema J., Tuveson D.A., Perez-Mancera P.A., Mustonen V., Fischer A.,
RA Adams D.J., Rust A., Chan-On W., Subimerb C., Dykema K., Furge K.,
RA Campbell P.J., Teh B.T., Stratton M.R., Futreal P.A.;
RT "Exome sequencing identifies frequent mutation of the SWI/SNF complex gene
RT PBRM1 in renal carcinoma.";
RL Nature 469:539-542(2011).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:12475935,
CC ECO:0000269|PubMed:15276201}; Peripheral membrane protein
CC {ECO:0000269|PubMed:12475935, ECO:0000269|PubMed:15276201}.
CC -!- TISSUE SPECIFICITY: Expressed in prostate, ovary, testis, placenta and
CC prostate cancer cell lines. Localizes to basal and terminal prostate
CC epithelial cells. {ECO:0000269|PubMed:12475935}.
CC -!- SIMILARITY: Belongs to the POTE family. {ECO:0000305}.
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DR EMBL; AY172978; AAO23914.1; -; mRNA.
DR EMBL; AP001465; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS13562.1; -.
DR RefSeq; NP_001244291.1; NM_001257362.1.
DR RefSeq; NP_778146.2; NM_174981.3.
DR AlphaFoldDB; Q86YR6; -.
DR SMR; Q86YR6; -.
DR BioGRID; 130460; 7.
DR IntAct; Q86YR6; 2.
DR STRING; 9606.ENSP00000299443; -.
DR iPTMnet; Q86YR6; -.
DR PhosphoSitePlus; Q86YR6; -.
DR SwissPalm; Q86YR6; -.
DR BioMuta; POTED; -.
DR DMDM; 269849632; -.
DR MassIVE; Q86YR6; -.
DR PaxDb; 9606-ENSP00000299443; -.
DR PeptideAtlas; Q86YR6; -.
DR ProteomicsDB; 70456; -.
DR Antibodypedia; 22148; 84 antibodies from 18 providers.
DR DNASU; 317754; -.
DR Ensembl; ENST00000299443.6; ENSP00000299443.5; ENSG00000166351.11.
DR GeneID; 100288966; -.
DR GeneID; 317754; -.
DR KEGG; hsa:100288966; -.
DR KEGG; hsa:317754; -.
DR MANE-Select; ENST00000299443.6; ENSP00000299443.5; NM_174981.6; NP_778146.2.
DR UCSC; uc002yjb.1; human.
DR AGR; HGNC:23822; -.
DR CTD; 317754; -.
DR DisGeNET; 100288966; -.
DR DisGeNET; 317754; -.
DR GeneCards; POTED; -.
DR HGNC; HGNC:23822; POTED.
DR HPA; ENSG00000166351; Tissue enriched (testis).
DR MIM; 607549; gene.
DR neXtProt; NX_Q86YR6; -.
DR OpenTargets; ENSG00000166351; -.
DR PharmGKB; PA164724756; -.
DR VEuPathDB; HostDB:ENSG00000166351; -.
DR eggNOG; KOG0676; Eukaryota.
DR GeneTree; ENSGT00940000163068; -.
DR HOGENOM; CLU_000134_9_2_1; -.
DR InParanoid; Q86YR6; -.
DR OMA; HEACIEG; -.
DR OrthoDB; 4734228at2759; -.
DR PhylomeDB; Q86YR6; -.
DR TreeFam; TF337879; -.
DR PathwayCommons; Q86YR6; -.
DR SignaLink; Q86YR6; -.
DR BioGRID-ORCS; 100288966; 1 hit in 10 CRISPR screens.
DR BioGRID-ORCS; 317754; 43 hits in 1044 CRISPR screens.
DR Pharos; Q86YR6; Tbio.
DR PRO; PR:Q86YR6; -.
DR Proteomes; UP000005640; Chromosome 21.
DR RNAct; Q86YR6; Protein.
DR Bgee; ENSG00000166351; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 2 other cell types or tissues.
DR ExpressionAtlas; Q86YR6; baseline.
DR Genevisible; Q86YR6; HS.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR039497; CC144C-like_CC_dom.
DR PANTHER; PTHR24147; ANKYRIN REPEAT DOMAIN 36-RELATED; 1.
DR PANTHER; PTHR24147:SF66; POTE ANKYRIN DOMAIN FAMILY MEMBER D; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF14915; CCDC144C; 1.
DR PRINTS; PR01415; ANKYRIN.
DR SMART; SM00248; ANK; 6.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 5.
PE 2: Evidence at transcript level;
KW ANK repeat; Cell membrane; Coiled coil; Membrane; Reference proteome;
KW Repeat.
FT CHAIN 1..584
FT /note="POTE ankyrin domain family member D"
FT /id="PRO_0000066913"
FT REPEAT 172..201
FT /note="ANK 1"
FT REPEAT 205..234
FT /note="ANK 2"
FT REPEAT 238..267
FT /note="ANK 3"
FT REPEAT 271..300
FT /note="ANK 4"
FT REPEAT 304..333
FT /note="ANK 5"
FT REPEAT 337..366
FT /note="ANK 6"
FT REGION 369..502
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 494..583
FT /evidence="ECO:0000255"
FT COMPBIAS 378..393
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 403..424
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 447..479
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 480..502
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 113
FT /note="G -> S (in dbSNP:rs6517869)"
FT /evidence="ECO:0000269|PubMed:12475935"
FT /id="VAR_016242"
FT VARIANT 135
FT /note="I -> V (in dbSNP:rs6517870)"
FT /evidence="ECO:0000269|PubMed:12475935"
FT /id="VAR_016243"
FT VARIANT 172
FT /note="E -> Q (in dbSNP:rs1429512928)"
FT /evidence="ECO:0000269|PubMed:21248752"
FT /id="VAR_064765"
FT CONFLICT 535
FT /note="M -> V (in Ref. 1; AAO23914)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 584 AA; 66394 MW; 837E4E63B393BB2B CRC64;
MVAEVCSMPT ASTVKKPFDL RSKMGKWCHH RFPCCRGSGK SNMGTSGDHD DSFMKMLRSK
MGKCCRHCFP CCRGSGTSNV GTSGDHENSF MKMLRSKMGK WCCHCFPCCR GSGKSNVGAW
GDYDHSAFME PRYHIRREDL DKLHRAAWWG KVPRKDLIVM LRDTDMNKRD KEKRTALHLA
SANGNSEVVQ LLLDRRCQLN VLDNKKRTAL IKAIQCQEDE CVLMLLEHGA DRNIPDEYGN
TALHYAIYNE DKLMAKALLL YGADIESKNK CGLTPLLLGV HEQKQQVVKF LIKKKANLNV
LDRYGRTALI LAVCCGSASI VNLLLEQNVD VSSQDLSGQT AREYAVSSHH HVICELLSDY
KEKQMLKISS ENSNPEQDLK LTSEEESQRL KVSENSQPEK MSQEPEINKD CDREVEEEIK
KHGSNPVGLP ENLTNGASAG NGDDGLIPQR RSRKPENQQF PDTENEEYHS DEQNDTRKQL
SEEQNTGISQ DEILTNKQKQ IEVAEQKMNS ELSLSHKKEE DLLRENSVLQ EEIAMLRLEL
DETKHQNQLR ENKILEEIES VKEKTDKLLR AMQLNEEALT KTNI
//
