ID Q87G24_VIBPA Unreviewed; 786 AA.
AC Q87G24;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 99.
DE RecName: Full=endopeptidase La {ECO:0000256|PROSITE-ProRule:PRU01122};
DE EC=3.4.21.53 {ECO:0000256|PROSITE-ProRule:PRU01122};
GN OrderedLocusNames=VPA1493 {ECO:0000313|EMBL:BAC62836.1};
OS Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=223926 {ECO:0000313|EMBL:BAC62836.1, ECO:0000313|Proteomes:UP000002493};
RN [1] {ECO:0000313|EMBL:BAC62836.1, ECO:0000313|Proteomes:UP000002493}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RIMD 2210633 {ECO:0000313|Proteomes:UP000002493};
RX PubMed=12620739; DOI=10.1016/S0140-6736(03)12659-1;
RA Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K.,
RA Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S.,
RA Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.;
RT "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism
RT distinct from that of V. cholerae.";
RL Lancet 361:743-749(2003).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Hydrolysis of proteins in presence of ATP.; EC=3.4.21.53;
CC Evidence={ECO:0000256|PROSITE-ProRule:PRU01122};
CC -!- SIMILARITY: Belongs to the peptidase S16 family. {ECO:0000256|PROSITE-
CC ProRule:PRU01122}.
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DR EMBL; BA000032; BAC62836.1; -; Genomic_DNA.
DR RefSeq; NP_801003.1; NC_004605.1.
DR RefSeq; WP_005478132.1; NC_004605.1.
DR AlphaFoldDB; Q87G24; -.
DR GeneID; 1192189; -.
DR KEGG; vpa:VPA1493; -.
DR PATRIC; fig|223926.6.peg.4418; -.
DR eggNOG; COG1067; Bacteria.
DR HOGENOM; CLU_014785_0_1_6; -.
DR Proteomes; UP000002493; Chromosome 2.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004176; F:ATP-dependent peptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0030163; P:protein catabolic process; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR041699; AAA_32.
DR InterPro; IPR046844; Lon-like_helical.
DR InterPro; IPR008269; Lon_proteolytic.
DR InterPro; IPR027065; Lon_Prtase.
DR InterPro; IPR046843; LonB_AAA-LID.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR PANTHER; PTHR10046:SF46; ARCHAEAL LON PROTEASE; 1.
DR PANTHER; PTHR10046; ATP DEPENDENT LON PROTEASE FAMILY MEMBER; 1.
DR Pfam; PF13654; AAA_32; 1.
DR Pfam; PF05362; Lon_C; 1.
DR Pfam; PF20436; LonB_AAA-LID; 1.
DR Pfam; PF20437; LonC_helical; 1.
DR PRINTS; PR00830; ENDOLAPTASE.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS51786; LON_PROTEOLYTIC; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU01122};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU01122}; Reference proteome {ECO:0000313|Proteomes:UP000002493};
KW Serine protease {ECO:0000256|PROSITE-ProRule:PRU01122}.
FT DOMAIN 562..757
FT /note="Lon proteolytic"
FT /evidence="ECO:0000259|PROSITE:PS51786"
FT ACT_SITE 652
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01122"
FT ACT_SITE 695
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01122"
SQ SEQUENCE 786 AA; 88102 MW; DBBBE466C6F85DEF CRC64;
MAILRLEPQQ LYSVADLENM PCKSTKELPP IDEIVGQERA QKAVEFAMSI KEKGYNIYAI
GQNGLGKRTM ILRYLNRHQH DADALFDWCY VANFEDTRTP KVLKLPCGIG NKLRVDIEAL
MGKLLNALPL AFDNEMYFSR ADRLKNQLAN KQQNELDRIS REAKEHGISL TITSQGDYQF
VAMNGDELHT EESFDALSKK EQEQFSDSID ALEVSLRSMV RELTEWEDTY SDKIKKLNDE
VTLDVITHFI KKLKVDYSEY SEIKTYLTEL QKDIVENADI FLDQSGEQGE IAAASLDKKL
PRRYKVNVLV SRNNSDFPIV VEENPNYHSL FGSIETATFK GTVFTDFSLI RAGSLHKANG
GVLLMDAQKV LEQPYVWDGL KRALRARQLS FTSLEKEVTL TGAVSLDPEP IPLDIKIILF
GDYRTYQLLQ HYDPEFSELF RVTADFEDEM KRTPESELHY ARFISSVVHD NNMLHCDRKA
IARIIEYSSR LSGDQSKLSL HSANIANLLR ESNYVARQAN SNMIRIGHVE EAMKNQEMRV
SRLRDSVMET FLNGTTLILT EGSAIGQVNA LSVLSTSDYM FGAPNRITAT TCYGDGDVID
IERSVDLGGS IHSKGVMILS AYLSSVFGKT ARVPLTTTIT FEQSYGGVDG DSASMAEFCA
VVSAFSKQPN RQDIAITGSM NQFGEAQPIG GVNEKIEGFY DVCVIKGRHS GQGVIIPRSN
VHNLMLRADI VKAVEKGEFH IWAIDHVTEA IELFTGKVAG EPTDEGSYPI DTIFGLAQAK
LNSLRK
//
