ID Q87II5_VIBPA Unreviewed; 497 AA.
AC Q87II5;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 108.
DE RecName: Full=methylmalonate-semialdehyde dehydrogenase (CoA acylating) {ECO:0000256|ARBA:ARBA00013048};
DE EC=1.2.1.27 {ECO:0000256|ARBA:ARBA00013048};
GN OrderedLocusNames=VPA0621 {ECO:0000313|EMBL:BAC61964.1};
OS Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633).
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Vibrionales; Vibrionaceae;
OC Vibrio.
OX NCBI_TaxID=223926 {ECO:0000313|EMBL:BAC61964.1, ECO:0000313|Proteomes:UP000002493};
RN [1] {ECO:0000313|EMBL:BAC61964.1, ECO:0000313|Proteomes:UP000002493}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RIMD 2210633 {ECO:0000313|Proteomes:UP000002493};
RX PubMed=12620739; DOI=10.1016/S0140-6736(03)12659-1;
RA Makino K., Oshima K., Kurokawa K., Yokoyama K., Uda T., Tagomori K.,
RA Iijima Y., Najima M., Nakano M., Yamashita A., Kubota Y., Kimura S.,
RA Yasunaga T., Honda T., Shinagawa H., Hattori M., Iida T.;
RT "Genome sequence of Vibrio parahaemolyticus: a pathogenic mechanism
RT distinct from that of V. cholerae.";
RL Lancet 361:743-749(2003).
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DR EMBL; BA000032; BAC61964.1; -; Genomic_DNA.
DR RefSeq; NP_800131.1; NC_004605.1.
DR RefSeq; WP_005483387.1; NC_004605.1.
DR AlphaFoldDB; Q87II5; -.
DR GeneID; 1191310; -.
DR KEGG; vpa:VPA0621; -.
DR PATRIC; fig|223926.6.peg.3560; -.
DR eggNOG; COG1012; Bacteria.
DR HOGENOM; CLU_005391_1_10_6; -.
DR Proteomes; UP000002493; Chromosome 2.
DR GO; GO:0004491; F:methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity; IEA:InterPro.
DR CDD; cd07085; ALDH_F6_MMSDH; 1.
DR InterPro; IPR016161; Ald_DH/histidinol_DH.
DR InterPro; IPR016163; Ald_DH_C.
DR InterPro; IPR016160; Ald_DH_CS_CYS.
DR InterPro; IPR016162; Ald_DH_N.
DR InterPro; IPR015590; Aldehyde_DH_dom.
DR InterPro; IPR010061; MeMal-semiAld_DH.
DR NCBIfam; TIGR01722; MMSDH; 1.
DR PANTHER; PTHR43866; MALONATE-SEMIALDEHYDE DEHYDROGENASE; 1.
DR PANTHER; PTHR43866:SF3; METHYLMALONATE-SEMIALDEHYDE DEHYDROGENASE [ACYLATING], MITOCHONDRIAL; 1.
DR Pfam; PF00171; Aldedh; 1.
DR SUPFAM; SSF53720; ALDH-like; 1.
DR PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
PE 4: Predicted;
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000002493}.
FT DOMAIN 14..477
FT /note="Aldehyde dehydrogenase"
FT /evidence="ECO:0000259|Pfam:PF00171"
SQ SEQUENCE 497 AA; 54429 MW; 889C464226D64ECC CRC64;
MTRLVPLFID GEFRESQTSD WVEVTNPATN DVIAYVPCST NAEMKAAIES AQTAFQSWKE
VAVSERARLM LRYQHLLKAH HDEIATLLSH ETGKIFADAK GDVWRGIEVV EQAANIASNL
MGETVENVAT DIDSHSIIQP LGVCCGITPF NFPAMIPLWM FPIAIASGNT FVLKPSEQVP
LTSIRLAELF EEAGAPKGVL QIVHGRKDQV DFLLAHPDIR AVSFVGSVPV AQYIYTTGTQ
YFKRVQAFAG AKNHMVVMPD ANKEHVINNL VGSSVGAAGQ RCMAISVAVF VGESKVWIAD
LKQEMAKIHP GAWDDEDAAY GPLISEQAKQ RVLGLIELGK QQGAVCELDG SQCEVEGFPD
GNWIGPTLFS GVTPNMSIYT QEIFGPVLVC IEVETLQEAI ELVNRNPYGN GTSIFTANGA
AARKYQHEIQ VGQVGINVPI PVPLPFFSFT GWRGSFYGDL HAYGKQAVRF YTETKTVTAR
WFDDDIPTGP NLTIQLR
//
