ID LDHD_LACPL Reviewed; 332 AA.
AC Q88VJ2; F9UQ12;
DT 28-NOV-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 01-MAY-2013, entry version 69.
DE RecName: Full=D-lactate dehydrogenase;
DE Short=D-LDH;
DE EC=1.1.1.28;
GN Name=ldhD; OrderedLocusNames=lp_2057;
OS Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactobacillus.
OX NCBI_TaxID=220668;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-793 / NCIMB 8826 / WCFS1;
RX PubMed=12566566; DOI=10.1073/pnas.0337704100;
RA Kleerebezem M., Boekhorst J., van Kranenburg R., Molenaar D.,
RA Kuipers O.P., Leer R., Tarchini R., Peters S.A., Sandbrink H.M.,
RA Fiers M.W.E.J., Stiekema W., Klein Lankhorst R.M., Bron P.A.,
RA Hoffer S.M., Nierop Groot M.N., Kerkhoven R., De Vries M., Ursing B.,
RA De Vos W.M., Siezen R.J.;
RT "Complete genome sequence of Lactobacillus plantarum WCFS1.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:1990-1995(2003).
CC -!- CATALYTIC ACTIVITY: (R)-lactate + NAD(+) = pyruvate + NADH.
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family.
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DR EMBL; AL935263; CCC79301.1; -; Genomic_DNA.
DR RefSeq; YP_004889815.1; NC_004567.2.
DR ProteinModelPortal; Q88VJ2; -.
DR SMR; Q88VJ2; 1-330.
DR STRING; 220668.lp_2057; -.
DR EnsemblBacteria; CCC79301; CCC79301; lp_2057.
DR GeneID; 1061762; -.
DR KEGG; lpl:lp_2057; -.
DR PATRIC; 22250201; VBILacPla27411_1742.
DR eggNOG; COG1052; -.
DR HOGENOM; HOG000136695; -.
DR KO; K03778; -.
DR OMA; DAVFVNC; -.
DR ProtClustDB; CLSK2520343; -.
DR BioCyc; MetaCyc:MONOMER-8683; -.
DR SABIO-RK; Q88VJ2; -.
DR GO; GO:0008720; F:D-lactate dehydrogenase activity; IEA:EC.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR Gene3D; 3.40.50.720; -; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR006140; D-isomer_2_OHA_DH_NAD-bd.
DR InterPro; IPR016040; NAD(P)-bd_dom.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR PROSITE; PS00065; D_2_HYDROXYACID_DH_1; 1.
DR PROSITE; PS00670; D_2_HYDROXYACID_DH_2; 1.
DR PROSITE; PS00671; D_2_HYDROXYACID_DH_3; 1.
PE 3: Inferred from homology;
KW Complete proteome; NAD; Oxidoreductase; Reference proteome.
FT CHAIN 1 332 D-lactate dehydrogenase.
FT /FTId=PRO_0000075955.
FT NP_BIND 155 156 NAD (By similarity).
FT NP_BIND 233 235 NAD (By similarity).
FT NP_BIND 296 299 NAD (By similarity).
FT ACT_SITE 235 235 By similarity.
FT ACT_SITE 264 264 By similarity.
FT ACT_SITE 296 296 Proton donor (By similarity).
FT BINDING 259 259 NAD (By similarity).
SQ SEQUENCE 332 AA; 37181 MW; BA65655CCF083F04 CRC64;
MKIIAYAVRD DERPFFDTWM KENPDVEVKL VPELLTEDNV DLAKGFDGAD VYQQKDYTAE
VLNKLADEGV KNISLRNVGV DNLDVPTVKA RGLNISNVPA YSPNAIAELS VTQLMQLLRQ
TPLFNKKLAK QDFRWAPDIA KELNTMTVGV IGTGRIGRAA IDIFKGFGAK VIGYDVYRNA
ELEKEGMYVD TLDELYAQAD VITLHVPALK DNYHMLNADA FSKMKDGAYI LNFARGTLID
SEDLIKALDS GKVAGAALDT YEYETKIFNK DLEGQTIDDK VFMNLFNRDN VLITPHTAFY
TETAVHNMVH VSMNSNKQFI ETGKADTQVK FD
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