ID GLPK1_LACPL Reviewed; 505 AA.
AC Q88ZF1; F9UTW7;
DT 31-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 01-MAY-2013, entry version 66.
DE RecName: Full=Glycerol kinase 1;
DE EC=2.7.1.30;
DE AltName: Full=ATP:glycerol 3-phosphotransferase 1;
DE AltName: Full=Glycerokinase 1;
DE Short=GK 1;
GN Name=glpK1; OrderedLocusNames=lp_0370;
OS Lactobacillus plantarum (strain ATCC BAA-793 / NCIMB 8826 / WCFS1).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Lactobacillaceae;
OC Lactobacillus.
OX NCBI_TaxID=220668;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-793 / NCIMB 8826 / WCFS1;
RX PubMed=12566566; DOI=10.1073/pnas.0337704100;
RA Kleerebezem M., Boekhorst J., van Kranenburg R., Molenaar D.,
RA Kuipers O.P., Leer R., Tarchini R., Peters S.A., Sandbrink H.M.,
RA Fiers M.W.E.J., Stiekema W., Klein Lankhorst R.M., Bron P.A.,
RA Hoffer S.M., Nierop Groot M.N., Kerkhoven R., De Vries M., Ursing B.,
RA De Vos W.M., Siezen R.J.;
RT "Complete genome sequence of Lactobacillus plantarum WCFS1.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:1990-1995(2003).
CC -!- FUNCTION: Key enzyme in the regulation of glycerol uptake and
CC metabolism (By similarity).
CC -!- CATALYTIC ACTIVITY: ATP + glycerol = ADP + sn-glycerol 3-
CC phosphate.
CC -!- PATHWAY: Polyol metabolism; glycerol degradation via glycerol
CC kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.
CC -!- SIMILARITY: Belongs to the FGGY kinase family.
CC -----------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution-NoDerivs License
CC -----------------------------------------------------------------------
DR EMBL; AL935263; CCC77887.1; -; Genomic_DNA.
DR RefSeq; YP_004888401.1; NC_004567.2.
DR ProteinModelPortal; Q88ZF1; -.
DR SMR; Q88ZF1; 5-490.
DR STRING; 220668.lp_0370; -.
DR EnsemblBacteria; CCC77887; CCC77887; lp_0370.
DR GeneID; 1064209; -.
DR KEGG; lpl:lp_0370; -.
DR PATRIC; 22247255; VBILacPla27411_0314.
DR eggNOG; COG0554; -.
DR HOGENOM; HOG000222134; -.
DR KO; K00864; -.
DR OMA; TKNTYRS; -.
DR ProtClustDB; PRK00047; -.
DR UniPathway; UPA00618; UER00672.
DR GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR GO; GO:0004370; F:glycerol kinase activity; IEA:HAMAP.
DR GO; GO:0019563; P:glycerol catabolic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0006072; P:glycerol-3-phosphate metabolic process; IEA:HAMAP.
DR HAMAP; MF_00186; Glycerol_kin; 1; -.
DR InterPro; IPR018485; Carb_kinase_FGGY_C.
DR InterPro; IPR018483; Carb_kinase_FGGY_CS.
DR InterPro; IPR018484; Carb_kinase_FGGY_N.
DR InterPro; IPR005999; Glycerol_kin.
DR PANTHER; PTHR10196:SF9; PTHR10196:SF9; 1.
DR Pfam; PF02782; FGGY_C; 1.
DR Pfam; PF00370; FGGY_N; 1.
DR TIGRFAMs; TIGR01311; glycerol_kin; 1.
DR PROSITE; PS00933; FGGY_KINASES_1; 1.
DR PROSITE; PS00445; FGGY_KINASES_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Complete proteome; Glycerol metabolism; Kinase;
KW Nucleotide-binding; Reference proteome; Transferase.
FT CHAIN 1 505 Glycerol kinase 1.
FT /FTId=PRO_0000059460.
FT NP_BIND 411 415 ATP (By similarity).
FT BINDING 13 13 Substrate (By similarity).
FT BINDING 17 17 ATP (By similarity).
FT BINDING 83 83 Substrate (By similarity).
FT BINDING 135 135 Substrate (By similarity).
FT BINDING 245 245 Substrate (By similarity).
FT BINDING 267 267 ATP (By similarity).
FT BINDING 310 310 ATP; via carbonyl oxygen (By similarity).
SQ SEQUENCE 505 AA; 55818 MW; 09D135885F9AB76A CRC64;
MTDKYIMAID EGTTSTRAII FDHAGHKVAD SQREFPQYFP QPGWVEHNAN EIWNAVLSTI
ANAFIESGIK PAQISGIGIT NQRETTIVWD KQTGLPIYNA IVWQSRQTAP IAEKLVKDGY
GDLIHQHTGL VTDAYFSATK IRWILDHVKG AQERAEKGEL LFGTIDTWLL WKLTGGATHV
TDYSNASRTM LFNIHDLKWD DQILQLLNIP AAMLPEVRTN SEVYGKTKDY HFFGSEVPIS
GMAGDQQAAL FGQLAFEPGT VKNTYGTGAF IVMNTGEKPQ LSDNNLLTTI GYGINGKVYY
ALEGSIFVAG SAIQWLRDGI RLVESAPDSE RAARESHNEN EVYVVPAFTG LGAPYWDSEA
RGSVFGLTRG TTREDFIKAT LQALAYQTRD VVETMKKDSG IEIPVLKVDG GAARNDWLMQ
FQADILDTQI MRAANLETTA LGAAFLAGLS VGYWQDLEEL KASYKPGTSF DPEMGPAERT
NLYEGWQAAV KATQVFKHTP YHAGK
//
