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Database: UniProt
Entry: Q890Y5
LinkDB: Q890Y5
Original site: Q890Y5 
ID   UVRC_CLOTE              Reviewed;         622 AA.
AC   Q890Y5;
DT   16-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   16-JUN-2003, sequence version 1.
DT   03-SEP-2014, entry version 69.
DE   RecName: Full=UvrABC system protein C;
DE            Short=Protein UvrC;
DE   AltName: Full=Excinuclease ABC subunit C;
GN   Name=uvrC; OrderedLocusNames=CTC_02497;
OS   Clostridium tetani (strain Massachusetts / E88).
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=212717;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Massachusetts / E88;
RX   PubMed=12552129; DOI=10.1073/pnas.0335853100;
RA   Brueggemann H., Baeumer S., Fricke W.F., Wiezer A., Liesegang H.,
RA   Decker I., Herzberg C., Martinez-Arias R., Merkl R., Henne A.,
RA   Gottschalk G.;
RT   "The genome sequence of Clostridium tetani, the causative agent of
RT   tetanus disease.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:1316-1321(2003).
CC   -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC       processing of DNA lesions. UvrC both incises the 5' and 3' sides
CC       of the lesion. The N-terminal half is responsible for the 3'
CC       incision and the C-terminal half is responsible for the 5'
CC       incision (By similarity).
CC   -!- SUBUNIT: Interacts with UvrB in an incision complex (By
CC       similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the UvrC family.
CC   -!- SIMILARITY: Contains 1 GIY-YIG domain.
CC   -!- SIMILARITY: Contains 1 UVR domain.
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DR   EMBL; AE015927; AAO36960.1; -; Genomic_DNA.
DR   RefSeq; NP_783023.1; NC_004557.1.
DR   RefSeq; WP_011100621.1; NC_004557.1.
DR   ProteinModelPortal; Q890Y5; -.
DR   SMR; Q890Y5; 7-98.
DR   STRING; 212717.CTC02497; -.
DR   EnsemblBacteria; AAO36960; AAO36960; CTC_02497.
DR   GeneID; 1060671; -.
DR   KEGG; ctc:CTC02497; -.
DR   PATRIC; 19513113; VBICloTet101274_2587.
DR   eggNOG; COG0322; -.
DR   KO; K03703; -.
DR   OMA; HRFVITF; -.
DR   OrthoDB; EOG6K13R9; -.
DR   BioCyc; CTET212717:GJAM-2307-MONOMER; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-HAMAP.
DR   GO; GO:0009432; P:SOS response; IEA:UniProtKB-HAMAP.
DR   Gene3D; 3.40.1440.10; -; 1.
DR   Gene3D; 4.10.860.10; -; 1.
DR   HAMAP; MF_00203; UvrC; 1.
DR   InterPro; IPR027299; GIY-YIG_dom.
DR   InterPro; IPR000305; GIY-YIG_SF.
DR   InterPro; IPR010994; RuvA_2-like.
DR   InterPro; IPR001943; UVR_dom.
DR   InterPro; IPR004791; UvrC.
DR   InterPro; IPR001162; UvrC_homol_region.
DR   Pfam; PF01541; GIY-YIG; 1.
DR   Pfam; PF02151; UVR; 1.
DR   Pfam; PF08459; UvrC_HhH_N; 1.
DR   SMART; SM00465; GIYc; 1.
DR   SUPFAM; SSF46600; SSF46600; 1.
DR   SUPFAM; SSF47781; SSF47781; 1.
DR   SUPFAM; SSF82771; SSF82771; 1.
DR   TIGRFAMs; TIGR00194; uvrC; 1.
DR   PROSITE; PS50164; GIY_YIG; 1.
DR   PROSITE; PS50151; UVR; 1.
DR   PROSITE; PS50165; UVRC; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; DNA damage; DNA excision; DNA repair;
KW   Excision nuclease; SOS response.
FT   CHAIN         1    622       UvrABC system protein C.
FT                                /FTId=PRO_0000138299.
FT   DOMAIN       13     92       GIY-YIG.
FT   DOMAIN      204    239       UVR.
SQ   SEQUENCE   622 AA;  72076 MW;  50408CBCBB2D8962 CRC64;
     MFDFEYQLKV LPEKPGVYLM KNSSDEVIYV GKAKILKNRV KQYFQQSKNH SEKVRVMVSN
     IAEFEYIITD SEMEALILEC NLIKKYRPKY NILLKDDKGY PYIKITINED FPRVFISRTI
     AKDGSRYFGP YTDYSAVRET IELIKKIFPI RSCKRYIRDG QKPTRPCLNY HIKLCSAPCG
     AHISKQGYAL IINDIVQLLS GKDKDILDKL KNQMEEASNS LQFEKAASLR DKIFAVKKIT
     EKQKIIMGSF QNEDYINIAK DEKDSCVQVF FVREGKIIGR EHFILEYTSD EREYKIIAEF
     IKDFYGGAAF VPKTVYVPDI EDKYLLEQWL TIRRGSKVEI KVPKRGEKIE LLNLVKKNAK
     LTLEQFKIKY LQDKALYEVA LAELSDILGF DDMPNRIEAY DISNIQGVDS VGSMVVFEKG
     RSKKSDYRRF KIKTVEGAND YHSMREILRR RFQRGIEEIQ QIQKRNLEFS SGKFSVFPDL
     ILIDGGKGHV NIALEVLKEL NIEIPVAGMV KDDSHTTRGI IYNNIEKDIS LDSNAMKLIT
     RIQDEVHRFA ISYHRTLRDK RVLKSILDDI PNIGTIRKKE LLKKFGSIES IKKASIDQLL
     ETPSIDKRSA LSIKEFFAPN EL
//
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