ID Q89167_VARV Unreviewed; 187 AA.
AC Q89167; A0A1U8QHH5; Q0NLS6; Q76PX9;
DT 01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT 01-NOV-1996, sequence version 1.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=A23R protein {ECO:0000313|EMBL:CAB54726.1};
DE SubName: Full=Holiday junction resolvase palmitylprotein {ECO:0000313|EMBL:ABF23500.1};
DE SubName: Full=ORF13R {ECO:0000313|EMBL:CAA53895.1};
GN Name=A23R {ECO:0000313|EMBL:CAB54726.1};
GN ORFNames=VARV_BRZ66_39_131 {ECO:0000313|EMBL:ABF23500.1},
GN VARV_UNK52_but_131 {ECO:0000313|EMBL:ABF29116.1};
OS Variola virus.
OC Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX NCBI_TaxID=10255 {ECO:0000313|EMBL:CAA53895.1};
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1] {ECO:0000313|EMBL:CAA53895.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=Garcia-1966 {ECO:0000313|EMBL:CAA53895.1};
RA Shchelkunov S.N., Totmenin A.V., Sosnovtsev S.V., Safronov P.F.,
RA Resenchuk S.M., Blinov V.M., Sandakhchiev L.S.;
RT "XhoI-D DNA fragment of Variola minor virus strain Garcia-1966.";
RL Submitted (NOV-1993) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:CAB54726.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Garcia-1966 {ECO:0000313|EMBL:CAB54726.1};
RA Shchelkunov S.N., Totmenin A.V., Gutorov V.V., Safronov P.F., Massung R.F.,
RA Loparev V.N., Knight J.C., Chizhikov V.E., Parsons J.M., Esposito J.J.,
RA Sosnovtsev S.;
RT "Analysis of the complete coding sequence of DNA of alastrim variola minor
RT virus strain Garcia-1966.";
RL Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|Proteomes:UP000001814, ECO:0000313|Proteomes:UP000160505}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Brazil 1966 {ECO:0000313|EMBL:ABF23500.1}, United Kingdom 1952
RC Butler {ECO:0000313|EMBL:ABF29116.1}, and Variola virus (isolate
RC Human/Brazil/v66-39/1966) {ECO:0000313|Proteomes:UP000001814};
RX PubMed=16873609; DOI=10.1126/science.1125134;
RA Esposito J.J., Sammons S.A., Frace A.M., Osborne J.D., Olsen-Rasmussen M.,
RA Zhang M., Govil D., Damon I.K., Kline R., Laker M., Li Y., Smith G.L.,
RA Meyer H., LeDuc J.W., Wohlhueter R.M.;
RT "Genome sequence diversity and clues to the evolution of variola (smallpox)
RT virus.";
RL Science 313:807-812(2006).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the RuvC family. Poxviruses-type subfamily.
CC {ECO:0000256|ARBA:ARBA00008810}.
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DR EMBL; DQ441419; ABF23500.1; -; Genomic_DNA.
DR EMBL; DQ441447; ABF29116.1; -; Genomic_DNA.
DR EMBL; X76268; CAA53895.1; -; Genomic_DNA.
DR EMBL; Y16780; CAB54726.1; -; Genomic_DNA.
DR PIR; D72166; D72166.
DR Proteomes; UP000001814; Genome.
DR Proteomes; UP000111493; Segment.
DR Proteomes; UP000160505; Genome.
DR GO; GO:0000400; F:four-way junction DNA binding; IEA:InterPro.
DR GO; GO:0016788; F:hydrolase activity, acting on ester bonds; IEA:InterPro.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:InterPro.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR InterPro; IPR006932; HJ-resolvase_A22.
DR InterPro; IPR012337; RNaseH-like_sf.
DR Pfam; PF04848; Pox_A22; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
PE 3: Inferred from homology;
SQ SEQUENCE 187 AA; 21964 MW; 7F3BCAB472239A24 CRC64;
METLTSSSQS LISSPMSKKD YSSEIICAFD IGAKNPARTV LEVKDNSVRV LDISKLDWSS
DWERRIAKDL SQYEYTTVLL ERQPRRSPYV KFIYFIKGFL YHTSAAKVIC VSPVMSGNSY
RDRKKRSVEA FFNWMDIFGL RDSVPDRRKL DDVADSFNLA MRYVLDKWNT NYTHYNRCKS
RNYIKKM
//
