ID Q891Y6_CLOTE Unreviewed; 593 AA.
AC Q891Y6;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 133.
DE RecName: Full=GTPase HflX {ECO:0000256|HAMAP-Rule:MF_00900};
DE AltName: Full=GTP-binding protein HflX {ECO:0000256|HAMAP-Rule:MF_00900};
GN Name=hflX {ECO:0000256|HAMAP-Rule:MF_00900,
GN ECO:0000313|EMBL:AAO36709.1};
GN OrderedLocusNames=CTC_02227 {ECO:0000313|EMBL:AAO36709.1};
OS Clostridium tetani (strain Massachusetts / E88).
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=212717 {ECO:0000313|EMBL:AAO36709.1, ECO:0000313|Proteomes:UP000001412};
RN [1] {ECO:0000313|EMBL:AAO36709.1, ECO:0000313|Proteomes:UP000001412}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Massachusetts / E88 {ECO:0000313|Proteomes:UP000001412};
RX PubMed=12552129; DOI=10.1073/pnas.0335853100;
RA Brueggemann H., Baumer S., Fricke W.F., Wiezer A., Liesegang H., Decker I.,
RA Herzberg C., Martinez-Arias R., Merkl R., Henne A., Gottschalk G.;
RT "The genome sequence of Clostridium tetani, the causative agent of tetanus
RT disease.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:1316-1321(2003).
CC -!- FUNCTION: GTPase that associates with the 50S ribosomal subunit and may
CC have a role during protein synthesis or ribosome biogenesis.
CC {ECO:0000256|HAMAP-Rule:MF_00900}.
CC -!- SUBUNIT: Monomer. Associates with the 50S ribosomal subunit.
CC {ECO:0000256|HAMAP-Rule:MF_00900}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00900}.
CC Note=May associate with membranes. {ECO:0000256|HAMAP-Rule:MF_00900}.
CC -!- SIMILARITY: Belongs to the TRAFAC class OBG-HflX-like GTPase
CC superfamily. HflX GTPase family. {ECO:0000256|HAMAP-Rule:MF_00900}.
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DR EMBL; AE015927; AAO36709.1; -; Genomic_DNA.
DR RefSeq; WP_011100370.1; NC_004557.1.
DR AlphaFoldDB; Q891Y6; -.
DR STRING; 212717.CTC_02227; -.
DR GeneID; 24254473; -.
DR KEGG; ctc:CTC_02227; -.
DR HOGENOM; CLU_019597_7_1_9; -.
DR OrthoDB; 9812272at2; -.
DR Proteomes; UP000001412; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd01878; HflX; 1.
DR Gene3D; 6.10.250.2860; -; 1.
DR Gene3D; 3.40.50.11060; GTPase HflX, N-terminal domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00900; GTPase_HflX; 1.
DR InterPro; IPR030394; G_HFLX_dom.
DR InterPro; IPR006073; GTP-bd.
DR InterPro; IPR032305; GTP-bd_M.
DR InterPro; IPR016496; GTPase_HflX.
DR InterPro; IPR025121; GTPase_HflX_N.
DR InterPro; IPR042108; GTPase_HflX_N_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR03156; GTP_HflX; 1.
DR PANTHER; PTHR10229:SF0; GTP-BINDING PROTEIN 6-RELATED; 1.
DR PANTHER; PTHR10229; GTP-BINDING PROTEIN HFLX; 1.
DR Pfam; PF16360; GTP-bdg_M; 1.
DR Pfam; PF13167; GTP-bdg_N; 1.
DR Pfam; PF01926; MMR_HSR1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51705; G_HFLX; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00900};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|HAMAP-
KW Rule:MF_00900}; Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00900}; Reference proteome {ECO:0000313|Proteomes:UP000001412}.
FT DOMAIN 362..539
FT /note="Hflx-type G"
FT /evidence="ECO:0000259|PROSITE:PS51705"
SQ SEQUENCE 593 AA; 67215 MW; 47406158EAC64946 CRC64;
MIYGNTNGVR DTVLEKLEEI YIMKIAKDEI CSRELISVLA YFTELIGREI SVAINRRGTV
ESVTLGDSST VELPILEIKQ KKLSGIRIVH THPSGNSTLS SLDLSALLKL KLDCIVAIGV
LEGEAKEITV GFCDIENDLL KWDSTKKLSV DEFLSMNILE KLDYIEDIIK GSKVEEDYGE
KAIIVGIENE ESLEELAELA RACEVSVLGR IFQKRSKMDP ALYIGSGKVS EVGYLAQKTR
ANVIIFDDEL SGSQLRNLEK YLGIKVIDRT TLILEIFSKR AKSREGKIQV ELAQLKYRLP
RLIGMGAVLS RTGGGIGTRG PGEQKLETDR RHIKNRIYDL SKELEKIKKI RKTQRASRNE
VPKVSLVGYT NSGKSTLRNY MYNLFQSKEL SKKDNVLEAD MLFATLDTTT RAIYLPDNRD
ITLTDTVGFI RKLPHDLVES FKSTLEEVMD ADLLLHVVDI SSIHYLEQIE AVNNVLRELN
ALNKPSIILI NKIDKINEDE LETKLENLKN YKYVCISAKE GINIDVLLKE IINKLPNKLK
KAEYLIPYNK QDVVAYLHRN AKVHEENYKD NGTYVRAEVD DLVYNVCNEY MIK
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