ID Y1941_CLOTE Reviewed; 456 AA.
AC Q892Z2;
DT 19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 01-MAY-2013, entry version 62.
DE RecName: Full=Uncharacterized RNA methyltransferase CTC_01941;
DE EC=2.1.1.-;
GN OrderedLocusNames=CTC_01941;
OS Clostridium tetani (strain Massachusetts / E88).
OC Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=212717;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Massachusetts / E88;
RX PubMed=12552129; DOI=10.1073/pnas.0335853100;
RA Brueggemann H., Baeumer S., Fricke W.F., Wiezer A., Liesegang H.,
RA Decker I., Herzberg C., Martinez-Arias R., Merkl R., Henne A.,
RA Gottschalk G.;
RT "The genome sequence of Clostridium tetani, the causative agent of
RT tetanus disease.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:1316-1321(2003).
CC -!- SIMILARITY: Belongs to the methyltransferase superfamily. RNA M5U
CC methyltransferase family.
CC -!- SIMILARITY: Contains 1 TRAM domain.
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DR EMBL; AE015927; AAO36450.1; -; Genomic_DNA.
DR RefSeq; NP_782513.1; NC_004557.1.
DR ProteinModelPortal; Q892Z2; -.
DR STRING; 212717.CTC01941; -.
DR EnsemblBacteria; AAO36450; AAO36450; CTC_01941.
DR GeneID; 1058721; -.
DR KEGG; ctc:CTC01941; -.
DR PATRIC; 19511937; VBICloTet101274_2016.
DR eggNOG; COG2265; -.
DR KO; K00557; -.
DR OMA; LNGLNNC; -.
DR ProtClustDB; CLSK882798; -.
DR BioCyc; CTET212717:GJAM-1780-MONOMER; -.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR GO; GO:0001510; P:RNA methylation; IEA:GOC.
DR GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR Gene3D; 2.40.50.140; -; 1.
DR InterPro; IPR001566; 23S_rRNA_MeTrfase_RlmD.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR002792; TRAM_dom.
DR InterPro; IPR010280; U5_MeTrfase.
DR Pfam; PF01938; TRAM; 1.
DR Pfam; PF05958; tRNA_U5-meth_tr; 1.
DR SUPFAM; SSF50249; Nucleic_acid_OB; 1.
DR TIGRFAMs; TIGR00479; rumA; 1.
DR PROSITE; PS50926; TRAM; 1.
DR PROSITE; PS01230; TRMA_1; 1.
DR PROSITE; PS01231; TRMA_2; FALSE_NEG.
PE 3: Inferred from homology;
KW 4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding;
KW Methyltransferase; S-adenosyl-L-methionine; Transferase.
FT CHAIN 1 456 Uncharacterized RNA methyltransferase
FT CTC_01941.
FT /FTId=PRO_0000161972.
FT DOMAIN 2 60 TRAM.
FT ACT_SITE 410 410 Nucleophile (By similarity).
FT METAL 73 73 Iron-sulfur (4Fe-4S) (By similarity).
FT METAL 79 79 Iron-sulfur (4Fe-4S) (By similarity).
FT METAL 82 82 Iron-sulfur (4Fe-4S) (By similarity).
FT METAL 162 162 Iron-sulfur (4Fe-4S) (By similarity).
FT BINDING 288 288 S-adenosyl-L-methionine (By similarity).
FT BINDING 317 317 S-adenosyl-L-methionine; via carbonyl
FT oxygen (By similarity).
FT BINDING 338 338 S-adenosyl-L-methionine (By similarity).
FT BINDING 383 383 S-adenosyl-L-methionine (By similarity).
SQ SEQUENCE 456 AA; 51549 MW; DB57AAC04A3730DC CRC64;
MAMRKGKEYE LNIEEIEFPS MGIAYHEGLK VYVKHGIPGQ KVLARITTKK KDHAKGKIIE
VLEDLPYKIE AKCPAFGQCG GCAHQDIPYE KQLEIKQHEI LELFKKANLD GFDFLPIEGS
PKQYEYRNKM EFTFGDLKKG GELNLGMHAK GMSFGIISAD ECKIVDEDYR NILNATLNYF
REKQLPHYRI MAREGYLRNL VIRKAENTGE VLVNLVTTSQ IDFNLDEYTE IIKSINYKGN
LVGILHTIND SLSDVVQCDK LNILYGRDYI IEDLLGLKFK ITPLSFFQTN SKGAEKLYSI
VRDFIGESKS KTVFDLYCGT GTIGQIVAPE AKKVIGIELI EEAVESAREN AKLNNLNNCE
FIAGDIAQVI KEVKQKPDVI ILDPPRPGVH PKALEYVIKF DSPTIVYVSC NPKTLVEDLK
VLVENGYVIE KVKGMDMFPS TPHVETVVGL RRKDTL
//
