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Database: UniProt
Entry: Q892Z2
LinkDB: Q892Z2
Original site: Q892Z2 
ID   Y1941_CLOTE             Reviewed;         456 AA.
AC   Q892Z2;
DT   19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   26-NOV-2014, entry version 73.
DE   RecName: Full=Uncharacterized RNA methyltransferase CTC_01941;
DE            EC=2.1.1.-;
GN   OrderedLocusNames=CTC_01941;
OS   Clostridium tetani (strain Massachusetts / E88).
OC   Bacteria; Firmicutes; Clostridia; Clostridiales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=212717;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Massachusetts / E88;
RX   PubMed=12552129; DOI=10.1073/pnas.0335853100;
RA   Brueggemann H., Baeumer S., Fricke W.F., Wiezer A., Liesegang H.,
RA   Decker I., Herzberg C., Martinez-Arias R., Merkl R., Henne A.,
RA   Gottschalk G.;
RT   "The genome sequence of Clostridium tetani, the causative agent of
RT   tetanus disease.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:1316-1321(2003).
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding
CC       methyltransferase superfamily. RNA M5U methyltransferase family.
CC       {ECO:0000255|PROSITE-ProRule:PRU01024}.
CC   -!- SIMILARITY: Contains 1 TRAM domain. {ECO:0000255|PROSITE-
CC       ProRule:PRU00208}.
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DR   EMBL; AE015927; AAO36450.1; -; Genomic_DNA.
DR   RefSeq; NP_782513.1; NC_004557.1.
DR   RefSeq; WP_011100110.1; NC_004557.1.
DR   ProteinModelPortal; Q892Z2; -.
DR   STRING; 212717.CTC01941; -.
DR   EnsemblBacteria; AAO36450; AAO36450; CTC_01941.
DR   GeneID; 1058721; -.
DR   KEGG; ctc:CTC01941; -.
DR   PATRIC; 19511937; VBICloTet101274_2016.
DR   eggNOG; COG2265; -.
DR   KO; K00557; -.
DR   OMA; CGGCTYQ; -.
DR   OrthoDB; EOG6V4GKM; -.
DR   BioCyc; CTET212717:GJAM-1780-MONOMER; -.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   Gene3D; 2.40.50.140; -; 1.
DR   Gene3D; 3.40.50.150; -; 1.
DR   InterPro; IPR001566; 23S_rRNA_MeTrfase_RlmD.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR029063; SAM-dependent_MTases-like.
DR   InterPro; IPR002792; TRAM_dom.
DR   InterPro; IPR010280; U5_MeTrfase_fam.
DR   Pfam; PF01938; TRAM; 1.
DR   Pfam; PF05958; tRNA_U5-meth_tr; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
DR   TIGRFAMs; TIGR00479; rumA; 1.
DR   PROSITE; PS51687; SAM_MT_RNA_M5U; 1.
DR   PROSITE; PS50926; TRAM; 1.
DR   PROSITE; PS01230; TRMA_1; 1.
PE   3: Inferred from homology;
KW   4Fe-4S; Complete proteome; Iron; Iron-sulfur; Metal-binding;
KW   Methyltransferase; Reference proteome; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN         1    456       Uncharacterized RNA methyltransferase
FT                                CTC_01941.
FT                                /FTId=PRO_0000161972.
FT   DOMAIN        2     60       TRAM. {ECO:0000255|PROSITE-
FT                                ProRule:PRU00208}.
FT   ACT_SITE    410    410       Nucleophile. {ECO:0000255|PROSITE-
FT                                ProRule:PRU01024}.
FT   METAL        73     73       Iron-sulfur (4Fe-4S). {ECO:0000250}.
FT   METAL        79     79       Iron-sulfur (4Fe-4S). {ECO:0000250}.
FT   METAL        82     82       Iron-sulfur (4Fe-4S). {ECO:0000250}.
FT   METAL       162    162       Iron-sulfur (4Fe-4S). {ECO:0000250}.
FT   BINDING     288    288       S-adenosyl-L-methionine.
FT                                {ECO:0000255|PROSITE-ProRule:PRU01024}.
FT   BINDING     317    317       S-adenosyl-L-methionine; via carbonyl
FT                                oxygen. {ECO:0000255|PROSITE-
FT                                ProRule:PRU01024}.
FT   BINDING     338    338       S-adenosyl-L-methionine.
FT                                {ECO:0000255|PROSITE-ProRule:PRU01024}.
FT   BINDING     383    383       S-adenosyl-L-methionine.
FT                                {ECO:0000255|PROSITE-ProRule:PRU01024}.
SQ   SEQUENCE   456 AA;  51549 MW;  DB57AAC04A3730DC CRC64;
     MAMRKGKEYE LNIEEIEFPS MGIAYHEGLK VYVKHGIPGQ KVLARITTKK KDHAKGKIIE
     VLEDLPYKIE AKCPAFGQCG GCAHQDIPYE KQLEIKQHEI LELFKKANLD GFDFLPIEGS
     PKQYEYRNKM EFTFGDLKKG GELNLGMHAK GMSFGIISAD ECKIVDEDYR NILNATLNYF
     REKQLPHYRI MAREGYLRNL VIRKAENTGE VLVNLVTTSQ IDFNLDEYTE IIKSINYKGN
     LVGILHTIND SLSDVVQCDK LNILYGRDYI IEDLLGLKFK ITPLSFFQTN SKGAEKLYSI
     VRDFIGESKS KTVFDLYCGT GTIGQIVAPE AKKVIGIELI EEAVESAREN AKLNNLNNCE
     FIAGDIAQVI KEVKQKPDVI ILDPPRPGVH PKALEYVIKF DSPTIVYVSC NPKTLVEDLK
     VLVENGYVIE KVKGMDMFPS TPHVETVVGL RRKDTL
//
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