ID Q89RM2_BRADU Unreviewed; 365 AA.
AC Q89RM2;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 110.
DE SubName: Full=3-isopropylmalate dehydrogenase {ECO:0000313|EMBL:BAC48006.1};
DE EC=1.1.1.85 {ECO:0000313|EMBL:BAC48006.1};
GN OrderedLocusNames=blr2741 {ECO:0000313|EMBL:BAC48006.1};
OS Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 /
OS NBRC 14792 / USDA 110).
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Nitrobacteraceae; Bradyrhizobium.
OX NCBI_TaxID=224911 {ECO:0000313|EMBL:BAC48006.1, ECO:0000313|Proteomes:UP000002526};
RN [1] {ECO:0000313|Proteomes:UP000002526}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110
RC {ECO:0000313|Proteomes:UP000002526};
RX PubMed=12597275; DOI=10.1093/dnares/9.6.189;
RA Kaneko T., Nakamura Y., Sato S., Minamisawa K., Uchiumi T., Sasamoto S.,
RA Watanabe A., Idesawa K., Iriguchi M., Kawashima K., Kohara M.,
RA Matsumoto M., Shimpo S., Tsuruoka H., Wada T., Yamada M., Tabata S.;
RT "Complete genomic sequence of nitrogen-fixing symbiotic bacterium
RT Bradyrhizobium japonicum USDA110.";
RL DNA Res. 9:189-197(2002).
CC -!- SIMILARITY: Belongs to the isocitrate and isopropylmalate
CC dehydrogenases family. {ECO:0000256|ARBA:ARBA00007769}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BA000040; BAC48006.1; -; Genomic_DNA.
DR RefSeq; NP_769381.1; NC_004463.1.
DR AlphaFoldDB; Q89RM2; -.
DR STRING; 224911.AAV28_10720; -.
DR EnsemblBacteria; BAC48006; BAC48006; BAC48006.
DR KEGG; bja:blr2741; -.
DR PATRIC; fig|224911.5.peg.2720; -.
DR eggNOG; COG0473; Bacteria.
DR HOGENOM; CLU_031953_0_1_5; -.
DR InParanoid; Q89RM2; -.
DR OrthoDB; 9767905at2; -.
DR PhylomeDB; Q89RM2; -.
DR Proteomes; UP000002526; Chromosome.
DR GO; GO:0003862; F:3-isopropylmalate dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0004449; F:isocitrate dehydrogenase (NAD+) activity; IBA:GO_Central.
DR GO; GO:0000287; F:magnesium ion binding; IEA:InterPro.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0006102; P:isocitrate metabolic process; IBA:GO_Central.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IBA:GO_Central.
DR Gene3D; 3.40.718.10; Isopropylmalate Dehydrogenase; 1.
DR InterPro; IPR019818; IsoCit/isopropylmalate_DH_CS.
DR InterPro; IPR024084; IsoPropMal-DH-like_dom.
DR PANTHER; PTHR11835; DECARBOXYLATING DEHYDROGENASES-ISOCITRATE, ISOPROPYLMALATE, TARTRATE; 1.
DR PANTHER; PTHR11835:SF34; ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA, MITOCHONDRIAL; 1.
DR Pfam; PF00180; Iso_dh; 1.
DR SMART; SM01329; Iso_dh; 1.
DR SUPFAM; SSF53659; Isocitrate/Isopropylmalate dehydrogenase-like; 1.
DR PROSITE; PS00470; IDH_IMDH; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000313|EMBL:BAC48006.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000002526}.
FT DOMAIN 14..358
FT /note="Isopropylmalate dehydrogenase-like"
FT /evidence="ECO:0000259|SMART:SM01329"
SQ SEQUENCE 365 AA; 39008 MW; 15478473967B9A55 CRC64;
MIAPALQFWG NVMQLIVLPG DGIGPEITTA TSGVLRAASE RFQLNLRLEE HAVGHASLKQ
FGTTVRPELL DIVRGADGLI LGPTATFDFK DEAHGEINPS RHFRKNLDLY ANVRPARTYA
GRPGRLGDFD LVVVRENTEG FYADRNMEQG NGEMLVTPDV AISLRRITRA CCERIAHAAC
RLAMKRRRHL TIVHKANVLK IGDGMFLDIC RAAAKGYAGL EVDDILVDAM MAHVVRNPDR
FDVIVATNMF GDILSDLTAE LSGSLGLGGS LNVGDRYAMA QAAHGSAPDI AGQDVANPVS
LILSTALLLA WHGERSGAVR YEEAARAIEA AVAKAIGEGR ATRDVGGRLG TIAAGAAIAE
ILQGA
//
