ID Q8A1I2_BACTN Unreviewed; 430 AA.
AC Q8A1I2;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 112.
DE RecName: Full=IPT/TIG domain-containing protein {ECO:0000259|Pfam:PF01833};
GN OrderedLocusNames=BT_3679 {ECO:0000313|EMBL:AAO78784.1};
OS Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 /
OS CCUG 10774 / NCTC 10582 / VPI-5482 / E50).
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=226186 {ECO:0000313|EMBL:AAO78784.1, ECO:0000313|Proteomes:UP000001414};
RN [1] {ECO:0000313|EMBL:AAO78784.1, ECO:0000313|Proteomes:UP000001414}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
RC VPI-5482 / E50 {ECO:0000313|Proteomes:UP000001414};
RX PubMed=12663928; DOI=10.1126/science.1080029;
RA Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C.,
RA Hooper L.V., Gordon J.I.;
RT "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.";
RL Science 299:2074-2076(2003).
RN [2] {ECO:0000313|EMBL:AAO78784.1, ECO:0000313|Proteomes:UP000001414}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
RC VPI-5482 / E50 {ECO:0000313|Proteomes:UP000001414};
RX PubMed=19321416; DOI=10.1073/pnas.0901529106;
RA Mahowald M.A., Rey F.E., Seedorf H., Turnbaugh P.J., Fulton R.S.,
RA Wollam A., Shah N., Wang C., Magrini V., Wilson R.K., Cantarel B.L.,
RA Coutinho P.M., Henrissat B., Crock L.W., Russell A., Verberkmoes N.C.,
RA Hettich R.L., Gordon J.I.;
RT "Characterizing a model human gut microbiota composed of members of its two
RT dominant bacterial phyla.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:5859-5864(2009).
RN [3] {ECO:0007829|PDB:3HRP}
RP X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 23-430.
RG Joint Center for Structural Genomics (JCSG);
RT "Crystal structure of Structural genomics protein of unknown function
RT (NP_812590.1) from Bacteroides thetaiotaomicron VPI-5482 at 1.70 A
RT resolution.";
RL Submitted (JUN-2009) to the PDB data bank.
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DR EMBL; AE015928; AAO78784.1; -; Genomic_DNA.
DR RefSeq; NP_812590.1; NC_004663.1.
DR RefSeq; WP_008767022.1; NC_004663.1.
DR PDB; 3HRP; X-ray; 1.70 A; A=23-430.
DR PDBsum; 3HRP; -.
DR AlphaFoldDB; Q8A1I2; -.
DR SMR; Q8A1I2; -.
DR STRING; 226186.BT_3679; -.
DR PaxDb; 226186-BT_3679; -.
DR DNASU; 1071845; -.
DR EnsemblBacteria; AAO78784; AAO78784; BT_3679.
DR GeneID; 60924849; -.
DR KEGG; bth:BT_3679; -.
DR PATRIC; fig|226186.12.peg.3740; -.
DR eggNOG; COG3391; Bacteria.
DR HOGENOM; CLU_035704_1_0_10; -.
DR InParanoid; Q8A1I2; -.
DR OrthoDB; 791543at2; -.
DR EvolutionaryTrace; Q8A1I2; -.
DR Proteomes; UP000001414; Chromosome.
DR CDD; cd00603; IPT_PCSR; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR PANTHER; PTHR13833; -; 1.
DR PANTHER; PTHR13833:SF71; NHL DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01833; TIG; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:3HRP};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022771};
KW Reference proteome {ECO:0000313|Proteomes:UP000001414};
KW Signal {ECO:0000256|SAM:SignalP}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..430
FT /note="IPT/TIG domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004302734"
FT DOMAIN 41..123
FT /note="IPT/TIG"
FT /evidence="ECO:0000259|Pfam:PF01833"
SQ SEQUENCE 430 AA; 47444 MW; 8B3E4D3464F1FF90 CRC64;
MRNCIFYSLV LALLFLIGSC KDSDDNKTTG ATYDPNQPVT VESFMPVEGK LREKVIVKGS
NFGTDKSKVK VYFVDEAAER LSTVIGIDNN TLYCLAPRQL PGGNRIKVIV DGKEVTTDGT
FKYEQAQNVS TISGSASKDG NDDGDLASAK FKYMWGIAAV GNNTVLAYQR DDPRVRLISV
DDNKVTTVHP GFKGGKPAVT KDKQRVYSIG WEGTHTVYVY MKASGWAPTR IGQLGSTFSG
KIGAVALDET EEWLYFVDSN KNFGRFNVKT QEVTLIKQLE LSGSLGTNPG PYLIYYFVDS
NFYMSDQNLS SVYKITPDGE CEWFCGSATQ KTVQDGLREE ALFAQPNGMT VDEDGNFYIV
DGFKGYCLRK LDILDGYVST VAGQVDVASQ IDGTPLEATF NYPYDICYDG EGGYWIAEAW
GKAIRKYAVE
//
