ID Q8A1J7_BACTN Unreviewed; 638 AA.
AC Q8A1J7;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 95.
DE SubName: Full=Alpha-glucosidase {ECO:0000313|EMBL:AAO78769.1};
GN OrderedLocusNames=BT_3664 {ECO:0000313|EMBL:AAO78769.1};
OS Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 /
OS CCUG 10774 / NCTC 10582 / VPI-5482 / E50).
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=226186 {ECO:0000313|EMBL:AAO78769.1, ECO:0000313|Proteomes:UP000001414};
RN [1] {ECO:0000313|EMBL:AAO78769.1, ECO:0000313|Proteomes:UP000001414}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
RC VPI-5482 / E50 {ECO:0000313|Proteomes:UP000001414};
RX PubMed=12663928; DOI=10.1126/science.1080029;
RA Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C.,
RA Hooper L.V., Gordon J.I.;
RT "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.";
RL Science 299:2074-2076(2003).
RN [2] {ECO:0000313|EMBL:AAO78769.1, ECO:0000313|Proteomes:UP000001414}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
RC VPI-5482 / E50 {ECO:0000313|Proteomes:UP000001414};
RX PubMed=19321416; DOI=10.1073/pnas.0901529106;
RA Mahowald M.A., Rey F.E., Seedorf H., Turnbaugh P.J., Fulton R.S.,
RA Wollam A., Shah N., Wang C., Magrini V., Wilson R.K., Cantarel B.L.,
RA Coutinho P.M., Henrissat B., Crock L.W., Russell A., Verberkmoes N.C.,
RA Hettich R.L., Gordon J.I.;
RT "Characterizing a model human gut microbiota composed of members of its two
RT dominant bacterial phyla.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:5859-5864(2009).
CC -!- COFACTOR:
CC Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC Evidence={ECO:0000256|ARBA:ARBA00001913};
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DR EMBL; AE015928; AAO78769.1; -; Genomic_DNA.
DR RefSeq; NP_812575.1; NC_004663.1.
DR RefSeq; WP_008767036.1; NC_004663.1.
DR AlphaFoldDB; Q8A1J7; -.
DR SMR; Q8A1J7; -.
DR STRING; 226186.BT_3664; -.
DR CAZy; GH97; Glycoside Hydrolase Family 97.
DR PaxDb; 226186-BT_3664; -.
DR EnsemblBacteria; AAO78769; AAO78769; BT_3664.
DR GeneID; 60924835; -.
DR KEGG; bth:BT_3664; -.
DR PATRIC; fig|226186.12.peg.3724; -.
DR eggNOG; COG1082; Bacteria.
DR HOGENOM; CLU_011166_1_1_10; -.
DR InParanoid; Q8A1J7; -.
DR OrthoDB; 1109141at2; -.
DR Proteomes; UP000001414; Chromosome.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:UniProt.
DR GO; GO:0008152; P:metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 2.70.98.10; -; 1.
DR Gene3D; 3.20.20.70; Aldolase class I; 1.
DR Gene3D; 2.60.40.1180; Golgi alpha-mannosidase II; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR014718; GH-type_carb-bd.
DR InterPro; IPR029483; GH97_C.
DR InterPro; IPR019563; GH97_catalytic.
DR InterPro; IPR029486; GH97_N.
DR InterPro; IPR013780; Glyco_hydro_b.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR35803; GLUCAN 1,4-ALPHA-GLUCOSIDASE SUSB-RELATED; 1.
DR PANTHER; PTHR35803:SF2; RETAINING ALPHA-GALACTOSIDASE; 1.
DR Pfam; PF14509; GH97_C; 1.
DR Pfam; PF14508; GH97_N; 1.
DR Pfam; PF10566; Glyco_hydro_97; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000001414}.
FT DOMAIN 32..284
FT /note="Glycosyl-hydrolase 97 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14508"
FT DOMAIN 289..543
FT /note="Glycosyl-hydrolase 97 catalytic"
FT /evidence="ECO:0000259|Pfam:PF10566"
FT DOMAIN 546..638
FT /note="Glycosyl-hydrolase 97 C-terminal oligomerisation"
FT /evidence="ECO:0000259|Pfam:PF14509"
SQ SEQUENCE 638 AA; 72647 MW; 105F408006A92D40 CRC64;
MKHSFNCLSY ELLLYVLICI PFCSCSQKDT GVISPNGKIC LSVEIKEDTE KDGFGKVFFN
VEYKDGKTSR RVLSDTRIGL ETQLMSFTDN IRLKSVSGTK LIEDDYVMLT GKRSHCQNRG
NERIFRFENE KAETLDIVFR AYDDGIVFRY SLPSVQDKDS LTSEHTAYYI PEGTKRWIQN
YSVGYEGFYP LKTRAERGKD NMWGYPLLLE PADSLFVLIT EANILRGHSG SRLYNGNDMN
QYQVRMTDDK LALGDSFTSP WRVLMIGSLS DIVESTLVTD VSEPNKISDT SWIMPGSASW
VYWAHNHGSK NFKIVKDYID LAVDMKWPYS LIDAEWNEMS NGGDIEDLIT YSLSRNIKPM
IWYNSSTAWM GPGPLYRLNS KENRIKEYTW LQKSGVVGVK IDFFPDDYSS NMDYYIDLLE
DAAKYKLMVN FHGATIPRGW QRTYPHLMTM EAVYGAEWYN NKPILTDRAA EHNVTLPFTR
NVIGSMDYTP GTFSDSQHPH ITTCGHELAL SVVFESALQH MPDRPEVYSS LPRKVREFLS
GLPTAWDDTK LLCGYPGADI VLARRKGDVW YIGGLNGTNE NKTLSFSLVP LQVEGKTMDV
FKDGVDDKSF AIEEDIQLSN DKMDMSCLPR GGFVAVIK
//
