ID Q8A3J3_BACTN Unreviewed; 285 AA.
AC Q8A3J3;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 115.
DE SubName: Full=Lipase {ECO:0000313|EMBL:AAO78067.1};
GN OrderedLocusNames=BT_2961 {ECO:0000313|EMBL:AAO78067.1};
OS Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 /
OS CCUG 10774 / NCTC 10582 / VPI-5482 / E50).
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=226186 {ECO:0000313|EMBL:AAO78067.1, ECO:0000313|Proteomes:UP000001414};
RN [1] {ECO:0000313|EMBL:AAO78067.1, ECO:0000313|Proteomes:UP000001414}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
RC VPI-5482 / E50 {ECO:0000313|Proteomes:UP000001414};
RX PubMed=12663928; DOI=10.1126/science.1080029;
RA Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C.,
RA Hooper L.V., Gordon J.I.;
RT "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.";
RL Science 299:2074-2076(2003).
RN [2] {ECO:0007829|PDB:3BZW}
RP X-RAY CRYSTALLOGRAPHY (1.87 ANGSTROMS) OF 23-285.
RA Palani K., Kumaran D., Burley S.K., Swaminathan S.;
RT "Crystal structure of a putative lipase from Bacteroides
RT thetaiotaomicron.";
RL Submitted (JAN-2008) to the PDB data bank.
RN [3] {ECO:0000313|EMBL:AAO78067.1, ECO:0000313|Proteomes:UP000001414}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
RC VPI-5482 / E50 {ECO:0000313|Proteomes:UP000001414};
RX PubMed=19321416; DOI=10.1073/pnas.0901529106;
RA Mahowald M.A., Rey F.E., Seedorf H., Turnbaugh P.J., Fulton R.S.,
RA Wollam A., Shah N., Wang C., Magrini V., Wilson R.K., Cantarel B.L.,
RA Coutinho P.M., Henrissat B., Crock L.W., Russell A., Verberkmoes N.C.,
RA Hettich R.L., Gordon J.I.;
RT "Characterizing a model human gut microbiota composed of members of its two
RT dominant bacterial phyla.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:5859-5864(2009).
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DR EMBL; AE015928; AAO78067.1; -; Genomic_DNA.
DR RefSeq; NP_811873.1; NC_004663.1.
DR RefSeq; WP_008761827.1; NZ_UYXG01000001.1.
DR PDB; 3BZW; X-ray; 1.87 A; A/B/C/D/E/F=23-285.
DR PDBsum; 3BZW; -.
DR AlphaFoldDB; Q8A3J3; -.
DR SMR; Q8A3J3; -.
DR STRING; 226186.BT_2961; -.
DR PaxDb; 226186-BT_2961; -.
DR DNASU; 1072704; -.
DR EnsemblBacteria; AAO78067; AAO78067; BT_2961.
DR GeneID; 60924143; -.
DR KEGG; bth:BT_2961; -.
DR PATRIC; fig|226186.12.peg.3011; -.
DR eggNOG; COG2755; Bacteria.
DR HOGENOM; CLU_1053166_0_0_10; -.
DR InParanoid; Q8A3J3; -.
DR OrthoDB; 9777593at2; -.
DR EvolutionaryTrace; Q8A3J3; -.
DR Proteomes; UP000001414; Chromosome.
DR GO; GO:0004622; F:lysophospholipase activity; IBA:GO_Central.
DR CDD; cd00229; SGNH_hydrolase; 1.
DR Gene3D; 3.40.50.1110; SGNH hydrolase; 1.
DR InterPro; IPR013830; SGNH_hydro.
DR InterPro; IPR036514; SGNH_hydro_sf.
DR PANTHER; PTHR30383; THIOESTERASE 1/PROTEASE 1/LYSOPHOSPHOLIPASE L1; 1.
DR PANTHER; PTHR30383:SF5; THIOESTERASE 1_PROTEASE 1_LYSOPHOSPHOLIPASE L1; 1.
DR Pfam; PF13472; Lipase_GDSL_2; 1.
DR SUPFAM; SSF52266; SGNH hydrolase; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:3BZW};
KW Reference proteome {ECO:0000313|Proteomes:UP000001414};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..285
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004303344"
FT DOMAIN 51..268
FT /note="SGNH hydrolase-type esterase"
FT /evidence="ECO:0000259|Pfam:PF13472"
SQ SEQUENCE 285 AA; 32545 MW; D9394C5F442280E3 CRC64;
MKNRFLIICT VLFLSSCLAY GQEQASVTND FSENKQGCIQ HPWQGKKVGY IGDSITDPNC
YGDNIKKYWD FLKEWLGITP FVYGISGRQW DDVPRQAEKL KKEHGGEVDA ILVFMGTNDY
NSSVPIGEWF TEQEEQVLSA HGEMKKMVTR KKRTPVMTQD TYRGRINIGI TQLKKLFPDK
QIVLLTPLHR SLANFGDKNV QPDESYQNGC GEYIDAYVQA IKEAGNIWGI PVIDFNAVTG
MNPMVEEQLI YFYDAGYDRL HPDTKGQERM ARTLMYQLLA LPVAF
//
