ID Q8A426_BACTN Unreviewed; 549 AA.
AC Q8A426;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 124.
DE SubName: Full=RNA polymerase ECF-type sigma factor {ECO:0000313|EMBL:AAO77884.1};
GN OrderedLocusNames=BT_2778 {ECO:0000313|EMBL:AAO77884.1};
OS Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 /
OS CCUG 10774 / NCTC 10582 / VPI-5482 / E50).
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=226186 {ECO:0000313|EMBL:AAO77884.1, ECO:0000313|Proteomes:UP000001414};
RN [1] {ECO:0000313|EMBL:AAO77884.1, ECO:0000313|Proteomes:UP000001414}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
RC VPI-5482 / E50 {ECO:0000313|Proteomes:UP000001414};
RX PubMed=12663928; DOI=10.1126/science.1080029;
RA Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C.,
RA Hooper L.V., Gordon J.I.;
RT "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.";
RL Science 299:2074-2076(2003).
RN [2] {ECO:0000313|EMBL:AAO77884.1, ECO:0000313|Proteomes:UP000001414}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
RC VPI-5482 / E50 {ECO:0000313|Proteomes:UP000001414};
RX PubMed=19321416; DOI=10.1073/pnas.0901529106;
RA Mahowald M.A., Rey F.E., Seedorf H., Turnbaugh P.J., Fulton R.S.,
RA Wollam A., Shah N., Wang C., Magrini V., Wilson R.K., Cantarel B.L.,
RA Coutinho P.M., Henrissat B., Crock L.W., Russell A., Verberkmoes N.C.,
RA Hettich R.L., Gordon J.I.;
RT "Characterizing a model human gut microbiota composed of members of its two
RT dominant bacterial phyla.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:5859-5864(2009).
CC -!- SIMILARITY: Belongs to the sigma-70 factor family. ECF subfamily.
CC {ECO:0000256|ARBA:ARBA00010641}.
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DR EMBL; AE015928; AAO77884.1; -; Genomic_DNA.
DR RefSeq; NP_811690.1; NC_004663.1.
DR RefSeq; WP_011108473.1; NC_004663.1.
DR AlphaFoldDB; Q8A426; -.
DR STRING; 226186.BT_2778; -.
DR PaxDb; 226186-BT_2778; -.
DR DNASU; 1075955; -.
DR EnsemblBacteria; AAO77884; AAO77884; BT_2778.
DR GeneID; 60923956; -.
DR KEGG; bth:BT_2778; -.
DR PATRIC; fig|226186.12.peg.2825; -.
DR eggNOG; COG1595; Bacteria.
DR HOGENOM; CLU_042247_0_0_10; -.
DR InParanoid; Q8A426; -.
DR OrthoDB; 1056775at2; -.
DR Proteomes; UP000001414; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0016987; F:sigma factor activity; IBA:GO_Central.
DR GO; GO:0006352; P:DNA-templated transcription initiation; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central.
DR CDD; cd06171; Sigma70_r4; 1.
DR Gene3D; 1.10.1740.10; -; 1.
DR Gene3D; 2.40.160.20; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011250; OMP/PagP_b-brl.
DR InterPro; IPR025665; OMP_b-brl_2.
DR InterPro; IPR039425; RNA_pol_sigma-70-like.
DR InterPro; IPR014284; RNA_pol_sigma-70_dom.
DR InterPro; IPR007627; RNA_pol_sigma70_r2.
DR InterPro; IPR013249; RNA_pol_sigma70_r4_t2.
DR InterPro; IPR013325; RNA_pol_sigma_r2.
DR InterPro; IPR013324; RNA_pol_sigma_r3/r4-like.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR NCBIfam; TIGR02937; sigma70-ECF; 1.
DR PANTHER; PTHR43133:SF46; ECF RNA POLYMERASE SIGMA FACTOR SIGG; 1.
DR PANTHER; PTHR43133; RNA POLYMERASE ECF-TYPE SIGMA FACTO; 1.
DR Pfam; PF13568; OMP_b-brl_2; 1.
DR Pfam; PF04542; Sigma70_r2; 1.
DR Pfam; PF08281; Sigma70_r4_2; 1.
DR SUPFAM; SSF56925; OMPA-like; 1.
DR SUPFAM; SSF88946; Sigma2 domain of RNA polymerase sigma factors; 1.
DR SUPFAM; SSF88659; Sigma3 and sigma4 domains of RNA polymerase sigma factors; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000001414};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 177..196
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 21..86
FT /note="RNA polymerase sigma-70 region 2"
FT /evidence="ECO:0000259|Pfam:PF04542"
FT DOMAIN 116..166
FT /note="RNA polymerase sigma factor 70 region 4 type 2"
FT /evidence="ECO:0000259|Pfam:PF08281"
FT DOMAIN 386..511
FT /note="Outer membrane protein beta-barrel"
FT /evidence="ECO:0000259|Pfam:PF13568"
SQ SEQUENCE 549 AA; 62932 MW; 327C8DEE528D1071 CRC64;
MDIKELVDLC KKGNEQALSL LYKTYSKKMM RICLHYIPDK QIAQDLLHDG FIVIFTSIET
LRTPEKLESW MGIIMKNISL RYLNQKSTNS AIPLSDIPED EEPIDNPLSS DSIPYDKITE
MVEKLPEGYS KIFKLAVLEG LSHKEIGKLL NIAPHSSSSQ LFRAKVLLKK MISDYRLILI
LVILFFFPTI HDYLYWKRKE TKDNHWSNNV IRKVKLDKKE ENESITSSGH ISHYKEDPPF
NTTLANLPRL ALDTSATGLS TTSEIKDSVE KQPVAKPSFT WEHAEKIITF SYSSQEFTSL
PKKKIGKWKM MLAGSVGPQL AQNLYKLMTT PHSDGLESGL PQQVNTWEEY YDYLNTRNQE
GTLGDSLTLM TIAKNNSGRI IEHQHHNSPI TIGLALNKKL NNHWSIETGL QYIYLKSEFT
TGKEYRIQKT QKLHYIGIPL RISYRFGNYK QFSFYSTAGL QMEIPIKGTL HTSHVTDSVP
INLGYQSLDV PLQWSINAST GVQYHFTPHT SIYIEPTINY YIPDGSSLRT IRKEHPVTFS
VPVGIRFSW
//
