ID Q8A6N5_BACTN Unreviewed; 438 AA.
AC Q8A6N5;
DT 01-JUN-2003, integrated into UniProtKB/TrEMBL.
DT 01-JUN-2003, sequence version 1.
DT 27-MAR-2024, entry version 111.
DE SubName: Full=Alpha-L-fucosidase {ECO:0000313|EMBL:AAO76949.1};
GN OrderedLocusNames=BT_1842 {ECO:0000313|EMBL:AAO76949.1};
OS Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / JCM 5827 /
OS CCUG 10774 / NCTC 10582 / VPI-5482 / E50).
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Bacteroidaceae;
OC Bacteroides.
OX NCBI_TaxID=226186 {ECO:0000313|EMBL:AAO76949.1, ECO:0000313|Proteomes:UP000001414};
RN [1] {ECO:0000313|EMBL:AAO76949.1, ECO:0000313|Proteomes:UP000001414}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
RC VPI-5482 / E50 {ECO:0000313|Proteomes:UP000001414};
RX PubMed=12663928; DOI=10.1126/science.1080029;
RA Xu J., Bjursell M.K., Himrod J., Deng S., Carmichael L.K., Chiang H.C.,
RA Hooper L.V., Gordon J.I.;
RT "A genomic view of the human-Bacteroides thetaiotaomicron symbiosis.";
RL Science 299:2074-2076(2003).
RN [2] {ECO:0000313|EMBL:AAO76949.1, ECO:0000313|Proteomes:UP000001414}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29148 / DSM 2079 / JCM 5827 / CCUG 10774 / NCTC 10582 /
RC VPI-5482 / E50 {ECO:0000313|Proteomes:UP000001414};
RX PubMed=19321416; DOI=10.1073/pnas.0901529106;
RA Mahowald M.A., Rey F.E., Seedorf H., Turnbaugh P.J., Fulton R.S.,
RA Wollam A., Shah N., Wang C., Magrini V., Wilson R.K., Cantarel B.L.,
RA Coutinho P.M., Henrissat B., Crock L.W., Russell A., Verberkmoes N.C.,
RA Hettich R.L., Gordon J.I.;
RT "Characterizing a model human gut microbiota composed of members of its two
RT dominant bacterial phyla.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:5859-5864(2009).
CC -!- FUNCTION: Alpha-L-fucosidase is responsible for hydrolyzing the alpha-
CC 1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the
CC carbohydrate moieties of glycoproteins.
CC {ECO:0000256|ARBA:ARBA00004071}.
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DR EMBL; AE015928; AAO76949.1; -; Genomic_DNA.
DR RefSeq; NP_810755.1; NC_004663.1.
DR RefSeq; WP_008767711.1; NZ_UYXG01000014.1.
DR AlphaFoldDB; Q8A6N5; -.
DR STRING; 226186.BT_1842; -.
DR CAZy; GH29; Glycoside Hydrolase Family 29.
DR PaxDb; 226186-BT_1842; -.
DR EnsemblBacteria; AAO76949; AAO76949; BT_1842.
DR GeneID; 60927831; -.
DR KEGG; bth:BT_1842; -.
DR PATRIC; fig|226186.12.peg.1891; -.
DR eggNOG; COG3669; Bacteria.
DR HOGENOM; CLU_002934_0_2_10; -.
DR InParanoid; Q8A6N5; -.
DR OrthoDB; 1389336at2; -.
DR BRENDA; 3.2.1.51; 709.
DR Proteomes; UP000001414; Chromosome.
DR GO; GO:0005764; C:lysosome; IBA:GO_Central.
DR GO; GO:0004560; F:alpha-L-fucosidase activity; IBA:GO_Central.
DR GO; GO:0006004; P:fucose metabolic process; IBA:GO_Central.
DR GO; GO:0016139; P:glycoside catabolic process; IBA:GO_Central.
DR Gene3D; 3.20.20.80; Glycosidases; 1.
DR InterPro; IPR016286; FUC_metazoa-typ.
DR InterPro; IPR000933; Glyco_hydro_29.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR10030; ALPHA-L-FUCOSIDASE; 1.
DR PANTHER; PTHR10030:SF46; ALPHA-L-FUCOSIDASE-RELATED; 1.
DR Pfam; PF01120; Alpha_L_fucos; 1.
DR PIRSF; PIRSF001092; Alpha-L-fucosidase; 1.
DR PRINTS; PR00741; GLHYDRLASE29.
DR SMART; SM00812; Alpha_L_fucos; 1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 1.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000001414};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..438
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004305240"
FT SITE 283
FT /note="May be important for catalysis"
FT /evidence="ECO:0000256|PIRSR:PIRSR001092-1"
SQ SEQUENCE 438 AA; 49758 MW; 1EDC116F63D9D52D CRC64;
MKTHFITFLL LVGMSLGISS RLHAQSSYQP GEENLKAREE FQDNKFGIFL HWGLYAMLAT
GEWTMTNNNL NYKEYAKLAG GFYPSKFDAD KWVAAIKASG AKYICLTSRH HDGFSMFDTQ
YSDFNIVKAT PFKRDIIKEL AAACSKQGIK LHFYYSHLDW TREDYPWGRT GRGTGRSNPQ
GDWKSYYQFM NNQLTELLTN YGPVGAIWFD GWWDQDGNPG FNWELPEQYA MIHKLQPGCL
IGNNHHQTPF AGEDIQIFER DLPGENTAGL SGQSVSHLPL ETCETMNGMW GYKITDQNYK
STKTLIHYLV KAAGKNANLL MNIGPQPDGE LPEVAVQRLK EMGEWMNQYG ETIYGTRGGA
VAPHDWGVTT QKGNKLYVHI LNLQDKALFL PLADKKVKKA VLFKNGTPVR FTKNKEGVLL
EFTEIPKDID YVVELTID
//
