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Database: UniProt
Entry: Q8AE93_9HIV1
LinkDB: Q8AE93_9HIV1
Original site: Q8AE93_9HIV1 
ID   Q8AE93_9HIV1            Unreviewed;       278 AA.
AC   Q8AE93;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   24-JAN-2024, entry version 110.
DE   SubName: Full=Integrase {ECO:0000313|EMBL:AAN05477.1};
DE   Flags: Fragment;
GN   Name=pol {ECO:0000313|EMBL:AAN05477.1};
OS   Human immunodeficiency virus 1.
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11676 {ECO:0000313|EMBL:AAN05477.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1] {ECO:0000313|EMBL:AAN05477.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=93RW004 {ECO:0000313|EMBL:AAN05477.1};
RX   PubMed=12396455; DOI=10.1089/08892220260235399;
RA   Burns C.C., Gleason L.M., Mozaffarian A., Giachetti C., Carr J.K.,
RA   Overbaugh J.;
RT   "Sequence variability of the integrase protein from a diverse collection of
RT   HIV type 1 isolates representing several subtypes.";
RL   AIDS Res. Hum. Retroviruses 18:1031-1041(2002).
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DR   EMBL; AF458239; AAN05477.1; -; Genomic_DNA.
DR   GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0016779; F:nucleotidyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0015074; P:DNA integration; IEA:UniProtKB-KW.
DR   GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR   GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.200; -; 1.
DR   Gene3D; 2.30.30.10; Integrase, C-terminal domain superfamily, retroviral; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR017856; Integrase-like_N.
DR   InterPro; IPR036862; Integrase_C_dom_sf_retrovir.
DR   InterPro; IPR001037; Integrase_C_retrovir.
DR   InterPro; IPR001584; Integrase_cat-core.
DR   InterPro; IPR003308; Integrase_Zn-bd_dom_N.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   PANTHER; PTHR41694; ENDOGENOUS RETROVIRUS GROUP K MEMBER POL PROTEIN; 1.
DR   PANTHER; PTHR41694:SF3; INTEGRASE-RELATED; 1.
DR   Pfam; PF00552; IN_DBD_C; 1.
DR   Pfam; PF02022; Integrase_Zn; 1.
DR   Pfam; PF00665; rve; 1.
DR   SUPFAM; SSF50122; DNA-binding domain of retroviral integrase; 1.
DR   SUPFAM; SSF46919; N-terminal Zn binding domain of HIV integrase; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS50994; INTEGRASE; 1.
DR   PROSITE; PS51027; INTEGRASE_DBD; 1.
DR   PROSITE; PS50876; ZF_INTEGRASE; 1.
PE   4: Predicted;
KW   DNA integration {ECO:0000256|ARBA:ARBA00022908};
KW   DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW   Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW   RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022918};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Viral genome integration {ECO:0000256|ARBA:ARBA00023195};
KW   Virus entry into host cell {ECO:0000256|ARBA:ARBA00023296};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00450}.
FT   DOMAIN          3..44
FT                   /note="Integrase-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50876"
FT   DOMAIN          54..204
FT                   /note="Integrase catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50994"
FT   DOMAIN          223..270
FT                   /note="Integrase-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51027"
FT   DNA_BIND        223..270
FT                   /note="Integrase-type"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00506"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAN05477.1"
FT   NON_TER         278
FT                   /evidence="ECO:0000313|EMBL:AAN05477.1"
SQ   SEQUENCE   278 AA;  31131 MW;  5A0162FD22384CD5 CRC64;
     FLDGIDKAQE EHERYHSNWR AMASDFNLPP VVAKEIVASC DKCQLKGEAM HGQVDCSPGI
     WQLDCTHLEG KVILVAVHVA SGYIEAEVIP AETGQETAYF LLKLAGRWPV KVVHTDNGSN
     FTSAAVKAAC WWANIQQEFG IPYNPQSQGV VESMNKELKK IIGQVREQAE HLKTAVQMAV
     FIHNFKRKGG IGGYSAGERI IDIIATDIQT KELQKQITKI QNFRVYYRDS RDPIWKGPAK
     LLWKGEGAVV IQDNSDIKVV PRRKAKIIRD YGKQMAGD
//
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