ID Q8AVM4_XENLA Unreviewed; 676 AA.
AC Q8AVM4;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 27-MAR-2024, entry version 90.
DE SubName: Full=SH2 domain-containing protein 3C {ECO:0000313|RefSeq:NP_001080296.1};
DE SubName: Full=Sh2d3c-prov protein {ECO:0000313|EMBL:AAH41733.1};
GN Name=sh2d3c.L {ECO:0000313|RefSeq:NP_001080296.1,
GN ECO:0000313|Xenbase:XB-GENE-6254468};
GN Synonyms=pro34088 {ECO:0000313|RefSeq:NP_001080296.1}, sh2d3c
GN {ECO:0000313|RefSeq:NP_001080296.1,
GN ECO:0000313|Xenbase:XB-GENE-6254468};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355 {ECO:0000313|EMBL:AAH41733.1};
RN [1] {ECO:0000313|RefSeq:NP_001080296.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12454917; DOI=10.1002/dvdy.10174;
RA Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA Richardson P.;
RT "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT initiative.";
RL Dev. Dyn. 225:384-391(2002).
RN [2] {ECO:0000313|EMBL:AAH41733.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000313|EMBL:AAH41733.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|RefSeq:NP_001080296.1}
RP IDENTIFICATION.
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; BC041733; AAH41733.1; -; mRNA.
DR RefSeq; NP_001080296.1; NM_001086827.1.
DR DNASU; 379988; -.
DR GeneID; 379988; -.
DR KEGG; xla:379988; -.
DR AGR; Xenbase:XB-GENE-6254468; -.
DR CTD; 379988; -.
DR Xenbase; XB-GENE-6254468; sh2d3c.L.
DR OrthoDB; 2953960at2759; -.
DR Proteomes; UP000186698; Chromosome 8L.
DR Bgee; 379988; Expressed in spleen and 17 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001784; F:phosphotyrosine residue binding; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd10337; SH2_BCAR3; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR044102; SH2_SHEP1/BCAR3/NSP1.
DR PANTHER; PTHR14247; BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3 HOMOLOG-LIKE PROTEIN; 1.
DR PANTHER; PTHR14247:SF6; SH2 DOMAIN-CONTAINING PROTEIN 3C; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50001; SH2; 1.
PE 2: Evidence at transcript level;
KW Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 39..138
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 402..670
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 277..326
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 277..323
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 676 AA; 75362 MW; 18CB3C0FF6D2E9DF CRC64;
MQVQFSKEKY ILETPPEKLH KELEEELKLN SSDPRSHAWY HGRIPREVSE SLVQRNGDFL
IRDSLTSLGD YVLTCRWKNE SLHFKINKVM VKTSDSYTRI QYLFEQESFD NIPALVRYYV
GSRRPVSEQS SAMIYCPINR TYPLRYLEAS YGLSPGRHGG SHSPQKGHMK RRSITMTDGL
TADKINKSNG CPNSGNSSQH HRDMIRNCAV SVDQIQDLHS PMSPISETPG SPAYSTVVRM
KPPVKPPVCA APGSPVLRRS SEPYVCPANN KAALNLADSS HSSPSHGHPN ISPSPSISSY
SDLDNGHYSQ LRPASSTHDA LSKSLPPKSY VERLRVDEGA KAGGIRGADE VDRDPGSFII
PTMEAKSSFI PSSFKSTLIP LDNKPLEMCI LKKVKELFAE VDAKTIAKHI TKTDCEVARI
LGVTKEMQRI MGVSSGMELL TLPHGRQLRL DLLERFHTMS IMIAVDILGC TGSTEERAAL
LHKTIQLAAE LKGTMGNMFS FAAVMNALEM SQISRLEQTW VTLRQRHTEG AILYEKKLKP
FLKSMNEGKE SLPLSNTTFP HIIPLITLLE RDSPLLDSGE PWDSSDNGVE VVMAHLEAAR
MVAHHGGLYR TNAEVRLQGF HPRSDLLEVS STEFQMRMLW GSRGASGSQA ERYDKFDKVL
AALSHKLEPS VRFSEL
//
