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Database: UniProt
Entry: Q8BIQ3
LinkDB: Q8BIQ3
Original site: Q8BIQ3 
ID   ZNF2_MOUSE              Reviewed;         427 AA.
AC   Q8BIQ3; Q7TPW3;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   09-JUL-2014, entry version 97.
DE   RecName: Full=Zinc finger protein 2;
DE   AltName: Full=Zinc finger protein 661;
DE            Short=Zfp-661;
GN   Name=Znf2; Synonyms=Zfp661;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Testis;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Egg;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus (Probable).
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family.
CC   -!- SIMILARITY: Contains 9 C2H2-type zinc fingers.
CC   -!- SIMILARITY: Contains 1 KRAB domain.
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DR   EMBL; AK033122; BAC28161.1; -; mRNA.
DR   EMBL; BC052876; AAH52876.1; -; mRNA.
DR   CCDS; CCDS16705.1; -.
DR   RefSeq; NP_001104499.1; NM_001111029.1.
DR   RefSeq; NP_082417.3; NM_028141.3.
DR   RefSeq; XP_006500289.1; XM_006500226.1.
DR   RefSeq; XP_006500290.1; XM_006500227.1.
DR   UniGene; Mm.46715; -.
DR   ProteinModelPortal; Q8BIQ3; -.
DR   SMR; Q8BIQ3; 138-418.
DR   BioGrid; 215203; 1.
DR   STRING; 10090.ENSMUSP00000076637; -.
DR   PhosphoSite; Q8BIQ3; -.
DR   PaxDb; Q8BIQ3; -.
DR   PRIDE; Q8BIQ3; -.
DR   Ensembl; ENSMUST00000077422; ENSMUSP00000076637; ENSMUSG00000034800.
DR   Ensembl; ENSMUST00000110366; ENSMUSP00000105995; ENSMUSG00000034800.
DR   Ensembl; ENSMUST00000110368; ENSMUSP00000105997; ENSMUSG00000034800.
DR   Ensembl; ENSMUST00000164551; ENSMUSP00000132820; ENSMUSG00000034800.
DR   GeneID; 72180; -.
DR   KEGG; mmu:72180; -.
DR   UCSC; uc008mfq.2; mouse.
DR   CTD; 72180; -.
DR   MGI; MGI:1919430; Zfp661.
DR   eggNOG; COG5048; -.
DR   GeneTree; ENSGT00750000117476; -.
DR   HOGENOM; HOG000234617; -.
DR   HOVERGEN; HBG018163; -.
DR   InParanoid; Q8BIQ3; -.
DR   KO; K09228; -.
DR   OMA; EEWRHLV; -.
DR   OrthoDB; EOG7KSX7Q; -.
DR   PhylomeDB; Q8BIQ3; -.
DR   TreeFam; TF340946; -.
DR   NextBio; 335637; -.
DR   PRO; PR:Q8BIQ3; -.
DR   Bgee; Q8BIQ3; -.
DR   CleanEx; MM_ZFP661; -.
DR   Genevestigator; Q8BIQ3; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:sequence-specific DNA binding transcription factor activity; IBA:RefGenome.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:RefGenome.
DR   GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.160.60; -; 9.
DR   InterPro; IPR001909; Krueppel-associated_box.
DR   InterPro; IPR007087; Znf_C2H2.
DR   InterPro; IPR015880; Znf_C2H2-like.
DR   InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR   Pfam; PF01352; KRAB; 1.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 9.
DR   SUPFAM; SSF109640; SSF109640; 1.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 9.
PE   2: Evidence at transcript level;
KW   Complete proteome; DNA-binding; Metal-binding; Nucleus;
KW   Reference proteome; Repeat; Transcription; Transcription regulation;
KW   Zinc; Zinc-finger.
FT   CHAIN         1    427       Zinc finger protein 2.
FT                                /FTId=PRO_0000274050.
FT   DOMAIN       14     85       KRAB.
FT   ZN_FING     169    191       C2H2-type 1.
FT   ZN_FING     197    219       C2H2-type 2.
FT   ZN_FING     225    247       C2H2-type 3.
FT   ZN_FING     253    275       C2H2-type 4.
FT   ZN_FING     281    303       C2H2-type 5.
FT   ZN_FING     309    331       C2H2-type 6.
FT   ZN_FING     337    359       C2H2-type 7.
FT   ZN_FING     365    387       C2H2-type 8.
FT   ZN_FING     393    415       C2H2-type 9; degenerate.
FT   CONFLICT     62     62       V -> A (in Ref. 2; AAH52876).
FT   CONFLICT     95     95       T -> A (in Ref. 2; AAH52876).
FT   CONFLICT    249    249       G -> E (in Ref. 2; AAH52876).
SQ   SEQUENCE   427 AA;  48640 MW;  AC70BD8A1D246F58 CRC64;
     MAAVSPPTRC QALVTFEDVA VTFTDDEWKR LVPVQRALYK AVMLENYESI ISLGLPVPRP
     DVILQFKRRG EPWIRGFHGS EEKTWPESVS LDLETKPETL DASRGTLREI HRKQSSLCPK
     REIQTLTGGP EPEKESPKAR TCKKPLSLDK GLHQMSAPSK KALTKHQDQE CSECGKTFFD
     HSSLIRHQRT HTGEKPYDCP ECGKAFSHRS SLSRHLMFHT GESPYECDAC GKAFFDRSSL
     TVHQRIHTGE KPFKCNDCGK AFFDRSSLTR HQRIHTGESP YECQQCGKAF SQKSILTRHL
     LTHTGRKPYE CRDCGKAFYG VTSLNRHQKV HTEEPRYQCS ECGKAFFDRS SLTQHQKIHT
     GDKPYECGEC GKAFSQRCRL TRHQRVHTGE KPFECSVCGK EFSSKSSIIQ HQRRYAKQGI
     DRGGSMS
//
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