ID ZNF2_MOUSE Reviewed; 427 AA.
AC Q8BIQ3; Q7TPW3;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 01-MAY-2013, entry version 86.
DE RecName: Full=Zinc finger protein 2;
DE AltName: Full=Zinc finger protein 661;
DE Short=Zfp-661;
GN Name=Znf2; Synonyms=Zfp661;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC Muroidea; Muridae; Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Egg;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA
RT project: the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus (Probable).
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family.
CC -!- SIMILARITY: Contains 9 C2H2-type zinc fingers.
CC -!- SIMILARITY: Contains 1 KRAB domain.
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DR EMBL; AK033122; BAC28161.1; -; mRNA.
DR EMBL; BC052876; AAH52876.1; -; mRNA.
DR IPI; IPI00222204; -.
DR RefSeq; NP_001104499.1; NM_001111029.1.
DR RefSeq; NP_082417.3; NM_028141.3.
DR UniGene; Mm.46715; -.
DR HSSP; P17028; 1X6E.
DR ProteinModelPortal; Q8BIQ3; -.
DR SMR; Q8BIQ3; 166-415.
DR STRING; 10090.ENSMUSP00000076637; -.
DR PhosphoSite; Q8BIQ3; -.
DR PaxDb; Q8BIQ3; -.
DR PRIDE; Q8BIQ3; -.
DR Ensembl; ENSMUST00000077422; ENSMUSP00000076637; ENSMUSG00000034800.
DR Ensembl; ENSMUST00000110366; ENSMUSP00000105995; ENSMUSG00000034800.
DR Ensembl; ENSMUST00000110368; ENSMUSP00000105997; ENSMUSG00000034800.
DR Ensembl; ENSMUST00000164551; ENSMUSP00000132820; ENSMUSG00000034800.
DR GeneID; 72180; -.
DR KEGG; mmu:72180; -.
DR CTD; 72180; -.
DR MGI; MGI:1919430; Zfp661.
DR eggNOG; COG5048; -.
DR GeneTree; ENSGT00700000104512; -.
DR HOGENOM; HOG000234617; -.
DR HOVERGEN; HBG018163; -.
DR InParanoid; Q8BIQ3; -.
DR KO; K09228; -.
DR OMA; SPYECSV; -.
DR OrthoDB; EOG4NVZK8; -.
DR NextBio; 335637; -.
DR ArrayExpress; Q8BIQ3; -.
DR Bgee; Q8BIQ3; -.
DR CleanEx; MM_ZFP661; -.
DR Genevestigator; Q8BIQ3; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
DR GO; GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
DR Gene3D; 3.30.160.60; -; 9.
DR InterPro; IPR001909; Krueppel-associated_box.
DR InterPro; IPR007087; Znf_C2H2.
DR InterPro; IPR015880; Znf_C2H2-like.
DR InterPro; IPR013087; Znf_C2H2/integrase_DNA-bd.
DR Pfam; PF01352; KRAB; 1.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 9.
DR SUPFAM; SSF109640; Krueppel-associated_box; 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 9.
PE 2: Evidence at transcript level;
KW Complete proteome; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation;
KW Zinc; Zinc-finger.
FT CHAIN 1 427 Zinc finger protein 2.
FT /FTId=PRO_0000274050.
FT DOMAIN 14 85 KRAB.
FT ZN_FING 169 191 C2H2-type 1.
FT ZN_FING 197 219 C2H2-type 2.
FT ZN_FING 225 247 C2H2-type 3.
FT ZN_FING 253 275 C2H2-type 4.
FT ZN_FING 281 303 C2H2-type 5.
FT ZN_FING 309 331 C2H2-type 6.
FT ZN_FING 337 359 C2H2-type 7.
FT ZN_FING 365 387 C2H2-type 8.
FT ZN_FING 393 415 C2H2-type 9; degenerate.
FT CONFLICT 62 62 V -> A (in Ref. 2; AAH52876).
FT CONFLICT 95 95 T -> A (in Ref. 2; AAH52876).
FT CONFLICT 249 249 G -> E (in Ref. 2; AAH52876).
SQ SEQUENCE 427 AA; 48640 MW; AC70BD8A1D246F58 CRC64;
MAAVSPPTRC QALVTFEDVA VTFTDDEWKR LVPVQRALYK AVMLENYESI ISLGLPVPRP
DVILQFKRRG EPWIRGFHGS EEKTWPESVS LDLETKPETL DASRGTLREI HRKQSSLCPK
REIQTLTGGP EPEKESPKAR TCKKPLSLDK GLHQMSAPSK KALTKHQDQE CSECGKTFFD
HSSLIRHQRT HTGEKPYDCP ECGKAFSHRS SLSRHLMFHT GESPYECDAC GKAFFDRSSL
TVHQRIHTGE KPFKCNDCGK AFFDRSSLTR HQRIHTGESP YECQQCGKAF SQKSILTRHL
LTHTGRKPYE CRDCGKAFYG VTSLNRHQKV HTEEPRYQCS ECGKAFFDRS SLTQHQKIHT
GDKPYECGEC GKAFSQRCRL TRHQRVHTGE KPFECSVCGK EFSSKSSIIQ HQRRYAKQGI
DRGGSMS
//
