ID Q8BIX2_MOUSE Unreviewed; 1054 AA.
AC Q8BIX2;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 24-JAN-2024, entry version 130.
DE RecName: Full=GCN1 activator of EIF2AK4 {ECO:0008006|Google:ProtNLM};
GN Name=Gcn1 {ECO:0000313|MGI:MGI:2444248};
GN Synonyms=Gcn1l1 {ECO:0000313|MGI:MGI:2444248};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|EMBL:BAC36565.1};
RN [1] {ECO:0000313|EMBL:BAC36565.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC36565.1};
RC TISSUE=Testis {ECO:0000313|EMBL:BAC36565.1};
RX PubMed=10349636; DOI=10.1016/S0076-6879(99)03004-9;
RA Carninci P., Hayashizaki Y.;
RT "High-efficiency full-length cDNA cloning.";
RL Methods Enzymol. 303:19-44(1999).
RN [2] {ECO:0000313|EMBL:BAC36565.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC36565.1};
RC TISSUE=Testis {ECO:0000313|EMBL:BAC36565.1};
RX PubMed=11042159; DOI=10.1101/gr.145100;
RA Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M.,
RA Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.;
RT "Normalization and subtraction of cap-trapper-selected cDNAs to prepare
RT full-length cDNA libraries for rapid discovery of new genes.";
RL Genome Res. 10:1617-1630(2000).
RN [3] {ECO:0000313|EMBL:BAC36565.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC36565.1};
RC TISSUE=Testis {ECO:0000313|EMBL:BAC36565.1};
RX PubMed=11076861; DOI=10.1101/gr.152600;
RA Shibata K., Itoh M., Aizawa K., Nagaoka S., Sasaki N., Carninci P.,
RA Konno H., Akiyama J., Nishi K., Kitsunai T., Tashiro H., Itoh M., Sumi N.,
RA Ishii Y., Nakamura S., Hazama M., Nishine T., Harada A., Yamamoto R.,
RA Matsumoto H., Sakaguchi S., Ikegami T., Kashiwagi K., Fujiwake S.,
RA Inoue K., Togawa Y., Izawa M., Ohara E., Watahiki M., Yoneda Y.,
RA Ishikawa T., Ozawa K., Tanaka T., Matsuura S., Kawai J., Okazaki Y.,
RA Muramatsu M., Inoue Y., Kira A., Hayashizaki Y.;
RT "RIKEN integrated sequence analysis (RISA) system--384-format sequencing
RT pipeline with 384 multicapillary sequencer.";
RL Genome Res. 10:1757-1771(2000).
RN [4] {ECO:0000313|EMBL:BAC36565.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC36565.1};
RC TISSUE=Testis {ECO:0000313|EMBL:BAC36565.1};
RX PubMed=11217851; DOI=10.1038/35055500;
RG The RIKEN Genome Exploration Research Group Phase II Team and the FANTOM Consortium;
RT "Functional annotation of a full-length mouse cDNA collection.";
RL Nature 409:685-690(2001).
RN [5] {ECO:0000313|EMBL:BAC36565.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC36565.1};
RC TISSUE=Testis {ECO:0000313|EMBL:BAC36565.1};
RX PubMed=12466851; DOI=10.1038/nature01266;
RG The FANTOM Consortium and the RIKEN Genome Exploration Research Group Phase I and II Team;
RT "Analysis of the mouse transcriptome based on functional annotation of
RT 60,770 full-length cDNAs.";
RL Nature 420:563-573(2002).
RN [6] {ECO:0000313|EMBL:BAC36565.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC36565.1};
RC TISSUE=Testis {ECO:0000313|EMBL:BAC36565.1};
RA Adachi J., Aizawa K., Akimura T., Arakawa T., Bono H., Carninci P.,
RA Fukuda S., Furuno M., Hanagaki T., Hara A., Hashizume W., Hayashida K.,
RA Hayatsu N., Hiramoto K., Hiraoka T., Hirozane T., Hori F., Imotani K.,
RA Ishii Y., Itoh M., Kagawa I., Kasukawa T., Katoh H., Kawai J., Kojima Y.,
RA Kondo S., Konno H., Kouda M., Koya S., Kurihara C., Matsuyama T.,
RA Miyazaki A., Murata M., Nakamura M., Nishi K., Nomura K., Numazaki R.,
RA Ohno M., Ohsato N., Okazaki Y., Saito R., Saitoh H., Sakai C., Sakai K.,
RA Sakazume N., Sano H., Sasaki D., Shibata K., Shinagawa A., Shiraki T.,
RA Sogabe Y., Tagami M., Tagawa A., Takahashi F., Takaku-Akahira S.,
RA Takeda Y., Tanaka T., Tomaru A., Toya T., Yasunishi A., Muramatsu M.,
RA Hayashizaki Y.;
RL Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
RN [7] {ECO:0000313|EMBL:BAC36565.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC36565.1};
RC TISSUE=Testis {ECO:0000313|EMBL:BAC36565.1};
RG The FANTOM Consortium;
RG Riken Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group);
RT "The Transcriptional Landscape of the Mammalian Genome.";
RL Science 309:1559-1563(2005).
RN [8] {ECO:0000313|EMBL:BAC36565.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=C57BL/6J {ECO:0000313|EMBL:BAC36565.1};
RC TISSUE=Testis {ECO:0000313|EMBL:BAC36565.1};
RX PubMed=16141073; DOI=10.1126/science.1112009;
RG RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group) and the FANTOM Consortium;
RT "Antisense Transcription in the Mammalian Transcriptome.";
RL Science 309:1564-1566(2005).
RN [9] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SIMILARITY: Belongs to the GCN1 family.
CC {ECO:0000256|ARBA:ARBA00007366}.
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DR EMBL; AK077013; BAC36565.1; -; mRNA.
DR RefSeq; NP_766307.2; NM_172719.2.
DR AlphaFoldDB; Q8BIX2; -.
DR SwissPalm; Q8BIX2; -.
DR MaxQB; Q8BIX2; -.
DR PeptideAtlas; Q8BIX2; -.
DR GeneID; 231659; -.
DR KEGG; mmu:231659; -.
DR UCSC; uc012ecf.1; mouse.
DR AGR; MGI:2444248; -.
DR CTD; 10985; -.
DR MGI; MGI:2444248; Gcn1.
DR OrthoDB; 6844at2759; -.
DR BioGRID-ORCS; 231659; 21 hits in 82 CRISPR screens.
DR ChiTaRS; Gcn1l1; mouse.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 4.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR021133; HEAT_type_2.
DR PANTHER; PTHR23346:SF7; EIF-2-ALPHA KINASE ACTIVATOR GCN1; 1.
DR PANTHER; PTHR23346; TRANSLATIONAL ACTIVATOR GCN1-RELATED; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR PROSITE; PS50077; HEAT_REPEAT; 2.
PE 1: Evidence at protein level;
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT REPEAT 42..80
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
FT REPEAT 390..427
FT /note="HEAT"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00103"
SQ SEQUENCE 1054 AA; 115425 MW; 449A91C92ACD2A94 CRC64;
MPIVQRAFQD RSTDTRKMAA QIIGNMYSLT DQKDLAPYLP SVTPGLKASL LDPVPEVRTV
SAKALGAMVK GMGESCFEDL LPWLMETLTY EQSSVDRSGA AQGLAEVMAG LGVEKLEKLM
PEIVATASKV DIAPHVRDGY IMMFNYLPIT FGDKFTPYVG PIIPCILKAL ADENEFVRDT
ALRAGQRVIS MYAETAIALL LPQLEQGLFD DLWRIRFSSV QLLGDLLFHI SGVTGKMTTE
TASEDDNFGT AQSNKAIITA LGVDRRNRVL AGLYMGRSDT QLVVRQASLH VWKIVVSNTP
RTLREILPTL FGLLLGFLAS TCADKRTIAA RTLGDLVRKL GEKILPEIIP ILEEGLRSQK
SDERQGVCIG LSEIMKSTSR DAVLFFSESL VPTARKALCD PLEEVREAAA KTFEQLHSTI
GHQALEDILP FLLKQLDDEE VSEFALDGLK QVMAVKSRVV LPYLVPKLTT PPVNTRVLAF
LSSVAGDALT RHLGVILPAV MLALKEKLGT PDEQLEMANC QAVILSVEDD TGHRIIIEDL
LEATRSPEVG MRQAAAIILN MYCSRSKADY SSHLRSLVSG LIRLFNDSSP VVLEESWDAL
NAITKLDAGN QLALIEELHK EIRFIGNECK GEHVPGFCLP KRGVTSILPV LREGVLTGSP
EQKEEAAKGL GLVIRLTSAD ALRPSVVSIT GPLIRILGDR FNWTVKAALL ETLSLLLGKV
GIALKPFLPQ LQTTFTKALQ DSNRGVRLKA ADALGKLISI HVKVDPLFTE LLNGIRAVED
PGIRDTMLQA LRFVIQGAGS KVDAAIRKNL VSLLLSMLGH DEDNTRISTA GCLGELCAFL
TDEELNTVLQ QCLLADVSGI DWMVRHGRSL ALSVAVNVAP SRLCAGRYSN EVQDMILSNA
VADRIPIAMS GIRGMGFLMK YHIETGSGQL PPRLSSLLIK CLQNPCSDIR LVAEKMIWWA
NKEPRPPLEP QTIKPILKAL LDNTKDKNTV VRAYSDQAIV NLLKMRRGEE LLQSLSKILD
VASLEALNEC SRRSLRKLAC QADSVEQVDD TILT
//
