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Database: UniProt
Entry: Q8BK84
LinkDB: Q8BK84
Original site: Q8BK84 
ID   DUPD1_MOUSE             Reviewed;         215 AA.
AC   Q8BK84; B2RW26;
DT   24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   19-MAR-2014, entry version 78.
DE   RecName: Full=Dual specificity phosphatase DUPD1;
DE            EC=3.1.3.16;
DE            EC=3.1.3.48;
GN   Name=Dupd1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA   Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA   Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA   Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA   Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA   Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA   di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA   Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA   Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA   Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA   Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA   Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA   Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA   Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA   Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA   Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA   Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA   Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA   Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA   Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA   Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA   Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA   Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA   Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA   Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA   Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA   Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA   Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA   Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA   Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA   Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA   Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RA   Brathwaite M., Waeltz P., Nagaraja R.;
RT   "Genomic sequence analysis in the mouse T-complex region.";
RL   Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein
CC       tyrosine + phosphate.
CC   -!- CATALYTIC ACTIVITY: [a protein]-serine/threonine phosphate + H(2)O
CC       = [a protein]-serine/threonine + phosphate.
CC   -!- SUBUNIT: Homodimer (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC       Non-receptor class dual specificity subfamily.
CC   -!- SIMILARITY: Contains 1 tyrosine-protein phosphatase domain.
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DR   EMBL; AK075665; BAC35883.1; -; mRNA.
DR   EMBL; AY294423; AAQ01518.1; -; Genomic_DNA.
DR   EMBL; BC147517; AAI47518.1; -; mRNA.
DR   EMBL; BC147531; AAI47532.1; -; mRNA.
DR   RefSeq; NP_001013848.1; NM_001013826.2.
DR   RefSeq; XP_006519280.1; XM_006519217.1.
DR   UniGene; Mm.295860; -.
DR   ProteinModelPortal; Q8BK84; -.
DR   SMR; Q8BK84; 31-205.
DR   PhosphoSite; Q8BK84; -.
DR   PRIDE; Q8BK84; -.
DR   Ensembl; ENSMUST00000073870; ENSMUSP00000073534; ENSMUSG00000063821.
DR   GeneID; 435391; -.
DR   KEGG; mmu:435391; -.
DR   UCSC; uc007sll.1; mouse.
DR   CTD; 338599; -.
DR   MGI; MGI:3647127; Dupd1.
DR   eggNOG; NOG270281; -.
DR   GeneTree; ENSGT00550000074474; -.
DR   HOGENOM; HOG000233767; -.
DR   HOVERGEN; HBG001524; -.
DR   InParanoid; B2RW26; -.
DR   KO; K14165; -.
DR   OMA; YLMIHKD; -.
DR   OrthoDB; EOG7CZK7N; -.
DR   TreeFam; TF105128; -.
DR   NextBio; 410078; -.
DR   PRO; PR:Q8BK84; -.
DR   Bgee; Q8BK84; -.
DR   Genevestigator; Q8BK84; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IBA:RefGenome.
DR   GO; GO:0035335; P:peptidyl-tyrosine dephosphorylation; IEA:GOC.
DR   InterPro; IPR020417; Atypical_DUSP.
DR   InterPro; IPR020405; Atypical_DUSP_famA.
DR   InterPro; IPR000340; Dual-sp_phosphatase_cat-dom.
DR   InterPro; IPR020422; Dual-sp_phosphatase_subgr_cat.
DR   InterPro; IPR024950; DUSP.
DR   InterPro; IPR000387; Tyr/Dual-sp_Pase.
DR   InterPro; IPR016130; Tyr_Pase_AS.
DR   PANTHER; PTHR10159; PTHR10159; 1.
DR   Pfam; PF00782; DSPc; 1.
DR   PRINTS; PR01908; ADSPHPHTASE.
DR   PRINTS; PR01909; ADSPHPHTASEA.
DR   SMART; SM00195; DSPc; 1.
DR   PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR   PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR   PROSITE; PS50054; TYR_PHOSPHATASE_DUAL; 1.
PE   2: Evidence at transcript level;
KW   Complete proteome; Cytoplasm; Hydrolase; Protein phosphatase;
KW   Reference proteome.
FT   CHAIN         1    215       Dual specificity phosphatase DUPD1.
FT                                /FTId=PRO_0000295879.
FT   DOMAIN       53    200       Tyrosine-protein phosphatase.
FT   REGION      145    152       Substrate binding (By similarity).
FT   ACT_SITE    146    146       Phosphocysteine intermediate (By
FT                                similarity).
SQ   SEQUENCE   215 AA;  24192 MW;  B30C3F0C3C169FD7 CRC64;
     MASGDTKTSV KHAHLCAERL SVREEEGDAE DYCTPGAFEL ERLFWKGSPQ YTHVNEVWPR
     LHIGDEATAL DRYGLQKAGF THVLNAAHGR WNVDTGPDYY RDMAIEYHGV EADDVPTFDL
     SIFFYSAAAF IDSALRDDHS KILVHCAMGR SRSATLVLAY LMIHKNMTLV DAIQQVAKNR
     CVLPNRGFLK QLRELDKQLV KQRRQAGPGD SDLGL
//
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