ID COR2A_MOUSE Reviewed; 524 AA.
AC Q8C0P5; Q3U6H8; Q8BW42;
DT 11-OCT-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 01-MAY-2013, entry version 78.
DE RecName: Full=Coronin-2A;
GN Name=Coro2a;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC Muroidea; Muridae; Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Bone marrow, Ovary, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
RA Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
RA Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
RA Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
RA Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
RA Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
RA di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
RA Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
RA Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
RA Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
RA Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
RA Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
RA Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
RA Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
RA Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
RA Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
RA Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
RA Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
RA Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
RA Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
RA Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
RA Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
RA Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
RA Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
RA Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
RA Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
RA Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
RA Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
RA Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
RA Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
RA Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
RA Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- SUBUNIT: Binds actin (By similarity). Component of the N-Cor
CC repressor complex, at least composed of NCOR1, NCOR2, HDAC3,
CC TBL1X, TBL1R, CORO2A and GPS2 (By similarity).
CC -!- SIMILARITY: Belongs to the WD repeat coronin family.
CC -!- SIMILARITY: Contains 5 WD repeats.
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DR EMBL; AK030097; BAC26782.1; -; mRNA.
DR EMBL; AK054394; BAC35761.2; -; mRNA.
DR EMBL; AK152490; BAE31261.1; -; mRNA.
DR EMBL; AK153134; BAE31746.1; -; mRNA.
DR IPI; IPI00309623; -.
DR RefSeq; NP_001158276.1; NM_001164804.1.
DR RefSeq; NP_849224.2; NM_178893.4.
DR UniGene; Mm.416311; -.
DR UniGene; Mm.485361; -.
DR ProteinModelPortal; Q8C0P5; -.
DR SMR; Q8C0P5; 9-400.
DR DIP; DIP-59203N; -.
DR PhosphoSite; Q8C0P5; -.
DR PaxDb; Q8C0P5; -.
DR PRIDE; Q8C0P5; -.
DR Ensembl; ENSMUST00000030021; ENSMUSP00000030021; ENSMUSG00000028337.
DR Ensembl; ENSMUST00000107756; ENSMUSP00000103385; ENSMUSG00000028337.
DR GeneID; 107684; -.
DR KEGG; mmu:107684; -.
DR CTD; 7464; -.
DR MGI; MGI:1345966; Coro2a.
DR eggNOG; COG2319; -.
DR GeneTree; ENSGT00550000074317; -.
DR HOGENOM; HOG000166356; -.
DR HOVERGEN; HBG059978; -.
DR InParanoid; Q8C0P5; -.
DR OrthoDB; EOG4GXFMG; -.
DR ChiTaRS; CORO2A; mouse.
DR NextBio; 359244; -.
DR ArrayExpress; Q8C0P5; -.
DR Bgee; Q8C0P5; -.
DR CleanEx; MM_CORO2A; -.
DR Genevestigator; Q8C0P5; -.
DR GermOnline; ENSMUSG00000028337; Mus musculus.
DR GO; GO:0015629; C:actin cytoskeleton; IBA:RefGenome.
DR GO; GO:0017053; C:transcriptional repressor complex; IBA:RefGenome.
DR GO; GO:0051015; F:actin filament binding; IBA:RefGenome.
DR GO; GO:0030036; P:actin cytoskeleton organization; IBA:RefGenome.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR027335; CORO2A.
DR InterPro; IPR015505; Coronin.
DR InterPro; IPR015048; DUF1899.
DR InterPro; IPR015049; DUF1900.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR017986; WD40_repeat_dom.
DR PANTHER; PTHR10856; PTHR10856; 1.
DR PANTHER; PTHR10856:SF2; PTHR10856:SF2; 1.
DR Pfam; PF08953; DUF1899; 1.
DR Pfam; PF08954; DUF1900; 1.
DR Pfam; PF00400; WD40; 3.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF50978; WD40_like; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Actin-binding; Coiled coil; Complete proteome; Reference proteome;
KW Repeat; WD repeat.
FT CHAIN 1 524 Coronin-2A.
FT /FTId=PRO_0000050929.
FT REPEAT 80 120 WD 1.
FT REPEAT 130 170 WD 2.
FT REPEAT 178 217 WD 3.
FT REPEAT 220 263 WD 4.
FT REPEAT 269 308 WD 5.
FT COILED 484 523 Potential.
FT CONFLICT 9 9 S -> R (in Ref. 1; BAC35761).
SQ SEQUENCE 524 AA; 59573 MW; 21F73CFB3B27A5E7 CRC64;
MSWHPQYRSS KFRHVYGKPA SKENCYDSVP ITRSVHDNHF CAVNPHFIAV VTECAGGGAF
LVIPLHQTGK LDPHYPKVCG HRGNVLDIKW NPFNDFEIAS CSEDATIKIW NIPKQLLTRN
LTTYRKELIG HARRVGLVEW HPTTANILFS AGYDYKVMVW NLDTKDSVIA GPVKTINCHQ
DVILSMSFNT NGSLLATTCK DRKIRIVDPR LGIVLQEASY KGHRANKVLF LGSLKKLLST
GTSRWNNRQM ALWDQENLSV PLTEEDLDGS SGVLFPFFDS DTSMLYIVGK GDGNIRYYEV
SMEKPHLTYL TEYRSYNPQK GIGIMPKRGL DVSSCEIFRF YKLITTKSLI EPVSMIVPRR
SESYQEDIYP PTAAAQPSLT AHEWLSGMNR GPIMMSLRPG SELLDSQTLP PERPLSNSMV
QVSPQPLEPM KQPAEDGDQA PFSLLEEKLA KWTAEHHLGE KSCLTNGFDV FECSPPKTEN
ELLQMFYRQQ EEIRRLRELL IQREVQTKQL ELEIKNLRMA LGQL
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