GenomeNet

Database: UniProt
Entry: Q8CFJ7
LinkDB: Q8CFJ7
Original site: Q8CFJ7 
ID   S2545_MOUSE             Reviewed;         288 AA.
AC   Q8CFJ7; Q3TC75; Q3UZE9; Q8VBZ7;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   27-MAR-2024, entry version 148.
DE   RecName: Full=Solute carrier family 25 member 45;
GN   Name=Slc25a45;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   STRAIN=C57BL/6J, and NOD;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   STRAIN=FVB/N; TISSUE=Liver, and Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   TISSUE SPECIFICITY.
RX   PubMed=19287344; DOI=10.1203/pdr.0b013e3181a283c1;
RA   Camacho J.A., Rioseco-Camacho N.;
RT   "The human and mouse SLC25A29 mitochondrial transporters rescue the
RT   deficient ornithine metabolism in fibroblasts of patients with the
RT   hyperornithinemia-hyperammonemia-homocitrullinuria (HHH) syndrome.";
RL   Pediatr. Res. 66:35-41(2009).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Kidney, Liver, Pancreas, and Testis;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC       Multi-pass membrane protein {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=Q8CFJ7-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q8CFJ7-2; Sequence=VSP_026250, VSP_026251;
CC   -!- TISSUE SPECIFICITY: Widely expressed, with highest levels in testis,
CC       liver and kidney and low levels in brain, including cortex, cerebellum,
CC       hippocampus and hypothalamus, and heart. {ECO:0000269|PubMed:19287344}.
CC   -!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29) family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH22156.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC       Sequence=BAE42082.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; AK133879; BAE21908.1; -; mRNA.
DR   EMBL; AK155754; BAE33419.1; -; mRNA.
DR   EMBL; AK169876; BAE41428.1; -; mRNA.
DR   EMBL; AK170869; BAE42082.1; ALT_FRAME; mRNA.
DR   EMBL; BC022156; AAH22156.1; ALT_INIT; mRNA.
DR   EMBL; BC037680; AAH37680.1; -; mRNA.
DR   CCDS; CCDS29482.1; -. [Q8CFJ7-1]
DR   RefSeq; NP_598915.1; NM_134154.3. [Q8CFJ7-1]
DR   RefSeq; XP_006531684.1; XM_006531621.3.
DR   AlphaFoldDB; Q8CFJ7; -.
DR   SMR; Q8CFJ7; -.
DR   BioGRID; 223254; 1.
DR   STRING; 10090.ENSMUSP00000025732; -.
DR   SwissPalm; Q8CFJ7; -.
DR   EPD; Q8CFJ7; -.
DR   jPOST; Q8CFJ7; -.
DR   MaxQB; Q8CFJ7; -.
DR   PaxDb; 10090-ENSMUSP00000025732; -.
DR   PeptideAtlas; Q8CFJ7; -.
DR   ProteomicsDB; 260766; -. [Q8CFJ7-1]
DR   ProteomicsDB; 260767; -. [Q8CFJ7-2]
DR   Pumba; Q8CFJ7; -.
DR   Antibodypedia; 7360; 47 antibodies from 20 providers.
DR   DNASU; 107375; -.
DR   Ensembl; ENSMUST00000025732.14; ENSMUSP00000025732.8; ENSMUSG00000024818.16. [Q8CFJ7-1]
DR   Ensembl; ENSMUST00000125114.8; ENSMUSP00000122076.2; ENSMUSG00000024818.16. [Q8CFJ7-2]
DR   Ensembl; ENSMUST00000155697.8; ENSMUSP00000121596.2; ENSMUSG00000024818.16. [Q8CFJ7-1]
DR   GeneID; 107375; -.
DR   KEGG; mmu:107375; -.
DR   UCSC; uc008gfq.1; mouse. [Q8CFJ7-1]
DR   UCSC; uc008gfr.1; mouse. [Q8CFJ7-2]
DR   AGR; MGI:2147731; -.
DR   CTD; 283130; -.
DR   MGI; MGI:2147731; Slc25a45.
DR   VEuPathDB; HostDB:ENSMUSG00000024818; -.
DR   eggNOG; KOG0758; Eukaryota.
DR   GeneTree; ENSGT00940000161002; -.
DR   HOGENOM; CLU_015166_16_1_1; -.
DR   InParanoid; Q8CFJ7; -.
DR   OMA; QLFAGGC; -.
DR   OrthoDB; 4064096at2759; -.
DR   PhylomeDB; Q8CFJ7; -.
DR   TreeFam; TF351739; -.
DR   BioGRID-ORCS; 107375; 2 hits in 76 CRISPR screens.
DR   PRO; PR:Q8CFJ7; -.
DR   Proteomes; UP000000589; Chromosome 19.
DR   RNAct; Q8CFJ7; Protein.
DR   Bgee; ENSMUSG00000024818; Expressed in small intestine Peyer's patch and 146 other cell types or tissues.
DR   ExpressionAtlas; Q8CFJ7; baseline and differential.
DR   Genevisible; Q8CFJ7; MM.
DR   GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR   GO; GO:0022857; F:transmembrane transporter activity; IBA:GO_Central.
DR   Gene3D; 1.50.40.10; Mitochondrial carrier domain; 1.
DR   InterPro; IPR002067; Mit_carrier.
DR   InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
DR   InterPro; IPR023395; Mt_carrier_dom_sf.
DR   PANTHER; PTHR45624; MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED; 1.
DR   PANTHER; PTHR45624:SF6; SOLUTE CARRIER FAMILY 25 MEMBER 45; 1.
DR   Pfam; PF00153; Mito_carr; 3.
DR   PRINTS; PR00926; MITOCARRIER.
DR   SUPFAM; SSF103506; Mitochondrial carrier; 1.
DR   PROSITE; PS50920; SOLCAR; 3.
PE   1: Evidence at protein level;
KW   Alternative splicing; Membrane; Mitochondrion;
KW   Mitochondrion inner membrane; Reference proteome; Repeat; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..288
FT                   /note="Solute carrier family 25 member 45"
FT                   /id="PRO_0000291827"
FT   TRANSMEM        6..26
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        58..78
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..122
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        166..186
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        202..222
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        266..286
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   REPEAT          1..83
FT                   /note="Solcar 1"
FT   REPEAT          97..191
FT                   /note="Solcar 2"
FT   REPEAT          199..286
FT                   /note="Solcar 3"
FT   VAR_SEQ         201..212
FT                   /note="SATVLVAGGFAG -> KWGEVGWGGGTA (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_026250"
FT   VAR_SEQ         213..288
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:16141072"
FT                   /id="VSP_026251"
SQ   SEQUENCE   288 AA;  31690 MW;  D86B0DE50886A11A CRC64;
     MPVEEFVAGW ISGAVGLVLG HPFDTVKVRL QTQSTYQGIV DCVVKTYRHE SVLGFFKGMS
     FPIASVALVN SVLFGVYSNT LLALTATSHQ ERRAQPPSYT NIFIAGCTGG LLQAYCLAPF
     DLIKVRLQNQ TEPRMQISSS MPRYRGPVHC AASILREEGP QGLFRGSWAL VLRDTPTLGM
     YFVTYEGLCR QYTPEGQNPS SATVLVAGGF AGIASWITAT PFDVIKSRMQ MDGLKGRKYG
     GMLDCMASSF RQEGIGVFFK GMTLNSARAF PVNAATFLSY EYLLRLWR
//
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