ID   Q8CGT4_MOUSE            Unreviewed;      1402 AA.
AC   Q8CGT4;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   27-MAR-2024, entry version 97.
DE   SubName: Full=Neuronal apoptosis inhibitory protein 5 {ECO:0000313|EMBL:AAN60206.1};
GN   Name=Naip5 {ECO:0000313|MGI:MGI:1298220};
GN   Synonyms=Birc1e {ECO:0000313|EMBL:AAN60206.1};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090 {ECO:0000313|EMBL:AAN60206.1};
RN   [1] {ECO:0000313|EMBL:AAN60206.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=129S1 {ECO:0000313|EMBL:AAN60206.1};
RX   PubMed=12526741; DOI=10.1016/S0960-9822(02)01359-3;
RA   Wright E.K., Goodart S.A., Growney J.D., Hadinoto V., Endrizzi M.G.,
RA   Long E.M., Sadigh K., Abney A.L., Bernstein-Hanley I., Dietrich W.F.;
RT   "Naip5 affects host susceptibility to the intracellular pathogen Legionella
RT   pneumophila.";
RL   Curr. Biol. 13:27-36(2003).
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DR   EMBL; AY146994; AAN60206.1; -; mRNA.
DR   MEROPS; I32.001; -.
DR   AGR; MGI:1298220; -.
DR   MGI; MGI:1298220; Naip5.
DR   ChiTaRS; Naip5; mouse.
DR   GO; GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IEA:InterPro.
DR   GO; GO:0043066; P:negative regulation of apoptotic process; IEA:InterPro.
DR   CDD; cd00022; BIR; 3.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR   InterPro; IPR001370; BIR_rpt.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR007111; NACHT_NTPase.
DR   InterPro; IPR028789; Naip.
DR   InterPro; IPR040535; NLRC4_HD.
DR   InterPro; IPR041075; NOD2_WH.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR46914; BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 1; 1.
DR   PANTHER; PTHR46914:SF1; BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 1; 1.
DR   Pfam; PF00653; BIR; 3.
DR   Pfam; PF05729; NACHT; 1.
DR   Pfam; PF17889; NLRC4_HD; 1.
DR   Pfam; PF17779; NOD2_WH; 1.
DR   SMART; SM00238; BIR; 3.
DR   SUPFAM; SSF57924; Inhibitor of apoptosis (IAP) repeat; 3.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF52047; RNI-like; 1.
DR   PROSITE; PS01282; BIR_REPEAT_1; 2.
DR   PROSITE; PS50143; BIR_REPEAT_2; 3.
DR   PROSITE; PS50837; NACHT; 1.
PE   2: Evidence at transcript level;
FT   DOMAIN          464..759
FT                   /note="NACHT"
FT                   /evidence="ECO:0000259|PROSITE:PS50837"
SQ   SEQUENCE   1402 AA;  159585 MW;  E8BC6CCA3EF5F372 CRC64;
     MAEHGESSED RISEIDYEFL PELSALLGVD AFQVAKSQEE EEHKERMKMK KGFNSQMRSE
     AKRLKTFETY DTFRSWTPQE MAAAGFYHTG VKLGVQCFCC SLILFGNSLR KLPIERHKKL
     RPECEFLQGK DVGNIGKYDI RVKSPEKMLR GGKARYHEEE ARLESFEDWP FYAHGTSPRV
     LSAAGFVFTG KRDTVQCFSC GGSLGNWEEG DDPWKEHAKW FPKCEFLQSK KSSEEIAQYI
     QGYEGFVHVT GEHFVKSWVR RELPMVSAYC NDSVFANEEL RMDMFKDWPQ ESPVGVEALV
     RAGFFYTGKK DIVRCFSCGG CLEKWAEGDD PMEDHIKFFP ECVFLQTLKS SAEVIPTLQS
     QYALPEATET TRESNHGDAA AVHSTVVDLG RSEAQWFQEA RSLSEQLRDN YTKATFRHMN
     LPEVCSSLGT DHLLSCDVSI ISKHISQPVQ EALTIPEVFS NLNSVMCVEG EAGSGKTTFL
     KRIAFLWASG CCPLLYRFQL VFYLSLSSIT PDQGLDNIIC TQLLGAGGCI SEACLSSIIQ
     QLQHQVLFLL DDYSGLASLP QALHTLITKN YLSRTCLLIA VHTNRVRDIR LYLGTSLEIQ
     EFPFYNTVSV LRKFFSHDII CVEKLIIYFI DNKDLQGVYK TPLFVAAVCT DWIQNASAQD
     KFQDVTLFQS YMQYLSLKYK ATAEPLQATV SSCGQLALTG LFSSCFEFNS DDLAEAGVDE
     DEKLTTLLMS KFTAQRLRPV YRFLGPLFQE FLAAVRLTEL LSSDRQEDQD LGLYYLRQID
     SPLKAINSFN IFLYYVSSHS SSKAAPTVVS HLLQLVDEKE SLENMSENED YMKLHPQTFL
     WFQFVRGLWL VSPESSSSFV SEHLLRLALI FAYESNTVAE CSPFILQFLR GKTLALRVLN
     LQYFRDHPES LLLLRSLKVS INGNKMSSYV DYSFKTYFEN LQPPAIDEEY TSAFEHISEW
     RRNFAQDEEI IKNYENIRPR ALPDISEGYW KLSPKPCKIP KLEVQVNNTD AADQALLQVL
     MEVFSASQSI EFRLFNSSGF LESICPALEL SKASVTKCSM SRLELSRAEQ ELLLTLPALQ
     SLEVSETNQL PDQLFHNLHK FLGLKELCVR LDGKPDVLSV LPGEFPNLLH MEKLSIQTST
     ESDLSKLVKF IQNFPNLHVF HLKCDFLSNC ESLMAVLASC KKLREIEFSG RCFEAMTFVN
     ILPNFVSLKI LNLKDQQFPD KETSEKFEAL GSLRNLEELL IPTGDGIHQV AKLIVRQCLQ
     LPCLRVLTFH DILDNDSVIE IARAATSGGF QKLENLDISM NHKITEEGYR NFFQALDNLP
     NLQELNICRN IPGRIQVQAT TVKALGQCVS RLPSLIRLHM LSWLLDEEDM KVINDVKERH
     PQSKRLIIFW KLIVPFSPVI LE
//