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Database: UniProt
Entry: Q8CH10_MUSSP
LinkDB: Q8CH10_MUSSP
Original site: Q8CH10_MUSSP 
ID   Q8CH10_MUSSP            Unreviewed;       417 AA.
AC   Q8CH10;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   22-FEB-2023, entry version 94.
DE   RecName: Full=Telomeric repeat-binding factor {ECO:0000256|PIRNR:PIRNR038016};
OS   Mus spretus (Western Mediterranean mouse) (Algerian mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10096 {ECO:0000313|EMBL:AAN77122.1};
RN   [1] {ECO:0000313|EMBL:AAN77122.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Kim S.-h., Parrinello S., Kim J., Campisi J.;
RL   Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AAN77122.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=12676566; DOI=10.1016/S0888-7543(02)00033-2;
RA   Kim S.-H., Parrinello S., Kim J., Campisi J.;
RT   "Mus musculus and Mus spretus homologues of the human telomere-associated
RT   protein TIN2.";
RL   Genomics 81:422-432(2003).
CC   -!- FUNCTION: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.
CC       {ECO:0000256|PIRNR:PIRNR038016}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000256|PIRNR:PIRNR038016}.
CC   -!- SUBCELLULAR LOCATION: Chromosome, telomere
CC       {ECO:0000256|ARBA:ARBA00004574}. Nucleus
CC       {ECO:0000256|PIRNR:PIRNR038016}.
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DR   EMBL; AF518766; AAN77122.1; -; mRNA.
DR   GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003691; F:double-stranded telomeric DNA binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0042803; F:protein homodimerization activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0000723; P:telomere maintenance; IEA:UniProtKB-UniRule.
DR   CDD; cd11660; SANT_TRF; 1.
DR   CDD; cd00280; TRFH; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   Gene3D; 1.25.40.210; Telomere repeat-binding factor, dimerisation domain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017930; Myb_dom.
DR   InterPro; IPR001005; SANT/Myb.
DR   InterPro; IPR013867; Telomere_rpt-bd_fac_dimer_dom.
DR   InterPro; IPR036507; Telomere_rpt-bd_fac_dimer_sf.
DR   InterPro; IPR017357; TERF1/2.
DR   PANTHER; PTHR46734:SF1; TELOMERIC REPEAT-BINDING FACTOR 1; 1.
DR   PANTHER; PTHR46734; TELOMERIC REPEAT-BINDING FACTOR 1 TERF1; 1.
DR   Pfam; PF00249; Myb_DNA-binding; 1.
DR   Pfam; PF08558; TRF; 1.
DR   PIRSF; PIRSF038016; Telomere_bd-1_Pin2; 1.
DR   SMART; SM00717; SANT; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   SUPFAM; SSF63600; Telomeric repeat binding factor (TRF) dimerisation domain; 1.
DR   PROSITE; PS51294; HTH_MYB; 1.
DR   PROSITE; PS50090; MYB_LIKE; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|PIRNR:PIRNR038016};
KW   Chromosome {ECO:0000256|PIRNR:PIRNR038016};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR038016};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR038016};
KW   Telomere {ECO:0000256|PIRNR:PIRNR038016}.
FT   DOMAIN          358..411
FT                   /note="Myb-like"
FT                   /evidence="ECO:0000259|PROSITE:PS50090"
FT   DOMAIN          360..415
FT                   /note="HTH myb-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51294"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          250..297
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          333..359
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        259..297
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   417 AA;  47827 MW;  EA194451ACA1E436 CRC64;
     MAETVSSAAR DAPSRESWTD SDSPEQEEVG DDAELLQCQM QLGTPREMEN AELVAEVEAV
     AAGWMLDFLC LSLCRAFRDG RSEDFRRTRD SAEAIIHGLQ RLTAYQLKTV YICQFLTRVA
     SGKALDAQFE VDERITPLES TLMIWNSIEK EHDEIKNLIK IQAVAVCMEI GSFKEAEEVF
     ERIFGDPEFY TSLERKLLKI ISQKDVFHSL FQHFSYNCMM EKIQSYVDYV LNEKSSSFLL
     KAATKVVENE KARTQPSKDR PDATNTGMDT EVGLNKGKSV NGQQSTETEP LVDTVSSIRS
     HKNALSQLXQ RSVPSDFSRH EARTGTLQCE TTMERNRRTS GRNRLCVSEN QPDTDDKSGR
     RKRQTWLWEE DRILKCGVKK YGEGNWAKIL SHYKFNNRTS VMLKDRWRTM KRLKLIS
//
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