ID Q8CH10_MUSSP Unreviewed; 417 AA.
AC Q8CH10;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 22-FEB-2023, entry version 94.
DE RecName: Full=Telomeric repeat-binding factor {ECO:0000256|PIRNR:PIRNR038016};
OS Mus spretus (Western Mediterranean mouse) (Algerian mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10096 {ECO:0000313|EMBL:AAN77122.1};
RN [1] {ECO:0000313|EMBL:AAN77122.1}
RP NUCLEOTIDE SEQUENCE.
RA Kim S.-h., Parrinello S., Kim J., Campisi J.;
RL Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:AAN77122.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12676566; DOI=10.1016/S0888-7543(02)00033-2;
RA Kim S.-H., Parrinello S., Kim J., Campisi J.;
RT "Mus musculus and Mus spretus homologues of the human telomere-associated
RT protein TIN2.";
RL Genomics 81:422-432(2003).
CC -!- FUNCTION: Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.
CC {ECO:0000256|PIRNR:PIRNR038016}.
CC -!- SUBUNIT: Homodimer. {ECO:0000256|PIRNR:PIRNR038016}.
CC -!- SUBCELLULAR LOCATION: Chromosome, telomere
CC {ECO:0000256|ARBA:ARBA00004574}. Nucleus
CC {ECO:0000256|PIRNR:PIRNR038016}.
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DR EMBL; AF518766; AAN77122.1; -; mRNA.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003691; F:double-stranded telomeric DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:UniProtKB-UniRule.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0000723; P:telomere maintenance; IEA:UniProtKB-UniRule.
DR CDD; cd11660; SANT_TRF; 1.
DR CDD; cd00280; TRFH; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 1.25.40.210; Telomere repeat-binding factor, dimerisation domain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017930; Myb_dom.
DR InterPro; IPR001005; SANT/Myb.
DR InterPro; IPR013867; Telomere_rpt-bd_fac_dimer_dom.
DR InterPro; IPR036507; Telomere_rpt-bd_fac_dimer_sf.
DR InterPro; IPR017357; TERF1/2.
DR PANTHER; PTHR46734:SF1; TELOMERIC REPEAT-BINDING FACTOR 1; 1.
DR PANTHER; PTHR46734; TELOMERIC REPEAT-BINDING FACTOR 1 TERF1; 1.
DR Pfam; PF00249; Myb_DNA-binding; 1.
DR Pfam; PF08558; TRF; 1.
DR PIRSF; PIRSF038016; Telomere_bd-1_Pin2; 1.
DR SMART; SM00717; SANT; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR SUPFAM; SSF63600; Telomeric repeat binding factor (TRF) dimerisation domain; 1.
DR PROSITE; PS51294; HTH_MYB; 1.
DR PROSITE; PS50090; MYB_LIKE; 1.
PE 2: Evidence at transcript level;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|PIRNR:PIRNR038016};
KW Chromosome {ECO:0000256|PIRNR:PIRNR038016};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR038016};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR038016};
KW Telomere {ECO:0000256|PIRNR:PIRNR038016}.
FT DOMAIN 358..411
FT /note="Myb-like"
FT /evidence="ECO:0000259|PROSITE:PS50090"
FT DOMAIN 360..415
FT /note="HTH myb-type"
FT /evidence="ECO:0000259|PROSITE:PS51294"
FT REGION 1..31
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 250..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 333..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 259..297
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 417 AA; 47827 MW; EA194451ACA1E436 CRC64;
MAETVSSAAR DAPSRESWTD SDSPEQEEVG DDAELLQCQM QLGTPREMEN AELVAEVEAV
AAGWMLDFLC LSLCRAFRDG RSEDFRRTRD SAEAIIHGLQ RLTAYQLKTV YICQFLTRVA
SGKALDAQFE VDERITPLES TLMIWNSIEK EHDEIKNLIK IQAVAVCMEI GSFKEAEEVF
ERIFGDPEFY TSLERKLLKI ISQKDVFHSL FQHFSYNCMM EKIQSYVDYV LNEKSSSFLL
KAATKVVENE KARTQPSKDR PDATNTGMDT EVGLNKGKSV NGQQSTETEP LVDTVSSIRS
HKNALSQLXQ RSVPSDFSRH EARTGTLQCE TTMERNRRTS GRNRLCVSEN QPDTDDKSGR
RKRQTWLWEE DRILKCGVKK YGEGNWAKIL SHYKFNNRTS VMLKDRWRTM KRLKLIS
//