ID Q8DND9_STRR6 Unreviewed; 416 AA.
AC Q8DND9;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 24-JAN-2024, entry version 116.
DE SubName: Full=Diaminopimelate decarboxylase {ECO:0000313|EMBL:AAL00595.1};
DE EC=4.1.1.20 {ECO:0000313|EMBL:AAL00595.1};
GN Name=lysA {ECO:0000313|EMBL:AAL00595.1};
GN OrderedLocusNames=spr1792 {ECO:0000313|EMBL:AAL00595.1};
OS Streptococcus pneumoniae (strain ATCC BAA-255 / R6).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=171101 {ECO:0000313|EMBL:AAL00595.1, ECO:0000313|Proteomes:UP000000586};
RN [1] {ECO:0000313|EMBL:AAL00595.1, ECO:0000313|Proteomes:UP000000586}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC BAA-255 / R6 {ECO:0000313|Proteomes:UP000000586};
RX PubMed=11544234; DOI=10.1128/JB.183.19.5709-5717.2001;
RA Hoskins J.A., Alborn W.Jr., Arnold J., Blaszczak L., Burgett S.,
RA DeHoff B.S., Estrem S., Fritz L., Fu D.-J., Fuller W., Geringer C.,
RA Gilmour R., Glass J.S., Khoja H., Kraft A., LaGace R., LeBlanc D.J.,
RA Lee L.N., Lefkowitz E.J., Lu J., Matsushima P., McAhren S., McHenney M.,
RA McLeaster K., Mundy C., Nicas T.I., Norris F.H., O'Gara M., Peery R.,
RA Robertson G.T., Rockey P., Sun P.-M., Winkler M.E., Yang Y.,
RA Young-Bellido M., Zhao G., Zook C., Baltz R.H., Jaskunas S.Richard.,
RA Rosteck P.R.Jr., Skatrud P.L., Glass J.I.;
RT "Genome of the bacterium Streptococcus pneumoniae strain R6.";
RL J. Bacteriol. 183:5709-5717(2001).
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|PIRSR:PIRSR600183-50};
CC -!- SIMILARITY: Belongs to the Orn/Lys/Arg decarboxylase class-II family.
CC {ECO:0000256|RuleBase:RU003737}.
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DR EMBL; AE007317; AAL00595.1; -; Genomic_DNA.
DR PIR; F98095; F98095.
DR RefSeq; NP_359384.1; NC_003098.1.
DR RefSeq; WP_000856527.1; NC_003098.1.
DR AlphaFoldDB; Q8DND9; -.
DR STRING; 171101.spr1792; -.
DR KEGG; spr:spr1792; -.
DR PATRIC; fig|171101.6.peg.1934; -.
DR eggNOG; COG0019; Bacteria.
DR HOGENOM; CLU_026444_0_2_9; -.
DR OMA; HGNAKSP; -.
DR Proteomes; UP000000586; Chromosome.
DR GO; GO:0008836; F:diaminopimelate decarboxylase activity; IBA:GO_Central.
DR GO; GO:0009089; P:lysine biosynthetic process via diaminopimelate; IBA:GO_Central.
DR CDD; cd06828; PLPDE_III_DapDC; 1.
DR Gene3D; 3.20.20.10; Alanine racemase; 1.
DR InterPro; IPR009006; Ala_racemase/Decarboxylase_C.
DR InterPro; IPR002986; DAP_deCOOHase_LysA.
DR InterPro; IPR022643; De-COase2_C.
DR InterPro; IPR022644; De-COase2_N.
DR InterPro; IPR000183; Orn/DAP/Arg_de-COase.
DR InterPro; IPR029066; PLP-binding_barrel.
DR PANTHER; PTHR43727; DIAMINOPIMELATE DECARBOXYLASE; 1.
DR PANTHER; PTHR43727:SF2; DIAMINOPIMELATE DECARBOXYLASE 1, CHLOROPLASTIC-RELATED; 1.
DR Pfam; PF02784; Orn_Arg_deC_N; 1.
DR Pfam; PF00278; Orn_DAP_Arg_deC; 1.
DR PRINTS; PR01181; DAPDCRBXLASE.
DR PRINTS; PR01179; ODADCRBXLASE.
DR SUPFAM; SSF50621; Alanine racemase C-terminal domain-like; 1.
DR SUPFAM; SSF51419; PLP-binding barrel; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000313|EMBL:AAL00595.1};
KW Pyridoxal phosphate {ECO:0000256|PIRSR:PIRSR600183-50};
KW Reference proteome {ECO:0000313|Proteomes:UP000000586}.
FT DOMAIN 30..277
FT /note="Orn/DAP/Arg decarboxylase 2 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF02784"
FT DOMAIN 279..366
FT /note="Orn/DAP/Arg decarboxylase 2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF00278"
FT ACT_SITE 339
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600183-50"
FT MOD_RES 54
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR600183-50"
SQ SEQUENCE 416 AA; 46649 MW; 24C329187B529F5B CRC64;
MKTPFINREE LEAIVAEFPT PFHLYDEKGI REKARAVNQA FSWNKGFKEY FAVKATPTPA
ILKILQEEGC GVDCSSYVEL LMSHKLDFLG SEIMFSSNNT PDKEYAYARE LGATINLDAF
EDIEHLERVA GIPEIISCRY NPGGVFELGT DIMDNPGEAK FGMTKDQLFE AFAILKEKGA
KTFGLHSFLA SNTVTHLYYP ELARQLFELA VEIKEKLGIW LDFINLSGGI GVNYRPDQEP
NDIALIGEGV RKVYEEVLTS AGLGQVKIFT ELGRFMLAPH GALVTRVTHK KETYRTYLGV
DASAVNLMRP AMYGAYHHIS NVTHPDGPAE AVDVVGSLCE NNDKFAVNRE LPHTEIGDLL
VIHDTGAHGF SMGYQYNAKL RSAEILYTEE GKARQIRRAE RPEDYFATLY GFDFEE
//