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Database: UniProt
Entry: Q8DND9_STRR6
LinkDB: Q8DND9_STRR6
Original site: Q8DND9_STRR6 
ID   Q8DND9_STRR6            Unreviewed;       416 AA.
AC   Q8DND9;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   24-JAN-2024, entry version 116.
DE   SubName: Full=Diaminopimelate decarboxylase {ECO:0000313|EMBL:AAL00595.1};
DE            EC=4.1.1.20 {ECO:0000313|EMBL:AAL00595.1};
GN   Name=lysA {ECO:0000313|EMBL:AAL00595.1};
GN   OrderedLocusNames=spr1792 {ECO:0000313|EMBL:AAL00595.1};
OS   Streptococcus pneumoniae (strain ATCC BAA-255 / R6).
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=171101 {ECO:0000313|EMBL:AAL00595.1, ECO:0000313|Proteomes:UP000000586};
RN   [1] {ECO:0000313|EMBL:AAL00595.1, ECO:0000313|Proteomes:UP000000586}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-255 / R6 {ECO:0000313|Proteomes:UP000000586};
RX   PubMed=11544234; DOI=10.1128/JB.183.19.5709-5717.2001;
RA   Hoskins J.A., Alborn W.Jr., Arnold J., Blaszczak L., Burgett S.,
RA   DeHoff B.S., Estrem S., Fritz L., Fu D.-J., Fuller W., Geringer C.,
RA   Gilmour R., Glass J.S., Khoja H., Kraft A., LaGace R., LeBlanc D.J.,
RA   Lee L.N., Lefkowitz E.J., Lu J., Matsushima P., McAhren S., McHenney M.,
RA   McLeaster K., Mundy C., Nicas T.I., Norris F.H., O'Gara M., Peery R.,
RA   Robertson G.T., Rockey P., Sun P.-M., Winkler M.E., Yang Y.,
RA   Young-Bellido M., Zhao G., Zook C., Baltz R.H., Jaskunas S.Richard.,
RA   Rosteck P.R.Jr., Skatrud P.L., Glass J.I.;
RT   "Genome of the bacterium Streptococcus pneumoniae strain R6.";
RL   J. Bacteriol. 183:5709-5717(2001).
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933,
CC         ECO:0000256|PIRSR:PIRSR600183-50};
CC   -!- SIMILARITY: Belongs to the Orn/Lys/Arg decarboxylase class-II family.
CC       {ECO:0000256|RuleBase:RU003737}.
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DR   EMBL; AE007317; AAL00595.1; -; Genomic_DNA.
DR   PIR; F98095; F98095.
DR   RefSeq; NP_359384.1; NC_003098.1.
DR   RefSeq; WP_000856527.1; NC_003098.1.
DR   AlphaFoldDB; Q8DND9; -.
DR   STRING; 171101.spr1792; -.
DR   KEGG; spr:spr1792; -.
DR   PATRIC; fig|171101.6.peg.1934; -.
DR   eggNOG; COG0019; Bacteria.
DR   HOGENOM; CLU_026444_0_2_9; -.
DR   OMA; HGNAKSP; -.
DR   Proteomes; UP000000586; Chromosome.
DR   GO; GO:0008836; F:diaminopimelate decarboxylase activity; IBA:GO_Central.
DR   GO; GO:0009089; P:lysine biosynthetic process via diaminopimelate; IBA:GO_Central.
DR   CDD; cd06828; PLPDE_III_DapDC; 1.
DR   Gene3D; 3.20.20.10; Alanine racemase; 1.
DR   InterPro; IPR009006; Ala_racemase/Decarboxylase_C.
DR   InterPro; IPR002986; DAP_deCOOHase_LysA.
DR   InterPro; IPR022643; De-COase2_C.
DR   InterPro; IPR022644; De-COase2_N.
DR   InterPro; IPR000183; Orn/DAP/Arg_de-COase.
DR   InterPro; IPR029066; PLP-binding_barrel.
DR   PANTHER; PTHR43727; DIAMINOPIMELATE DECARBOXYLASE; 1.
DR   PANTHER; PTHR43727:SF2; DIAMINOPIMELATE DECARBOXYLASE 1, CHLOROPLASTIC-RELATED; 1.
DR   Pfam; PF02784; Orn_Arg_deC_N; 1.
DR   Pfam; PF00278; Orn_DAP_Arg_deC; 1.
DR   PRINTS; PR01181; DAPDCRBXLASE.
DR   PRINTS; PR01179; ODADCRBXLASE.
DR   SUPFAM; SSF50621; Alanine racemase C-terminal domain-like; 1.
DR   SUPFAM; SSF51419; PLP-binding barrel; 1.
PE   3: Inferred from homology;
KW   Lyase {ECO:0000313|EMBL:AAL00595.1};
KW   Pyridoxal phosphate {ECO:0000256|PIRSR:PIRSR600183-50};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000586}.
FT   DOMAIN          30..277
FT                   /note="Orn/DAP/Arg decarboxylase 2 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF02784"
FT   DOMAIN          279..366
FT                   /note="Orn/DAP/Arg decarboxylase 2 C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00278"
FT   ACT_SITE        339
FT                   /note="Proton donor"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600183-50"
FT   MOD_RES         54
FT                   /note="N6-(pyridoxal phosphate)lysine"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR600183-50"
SQ   SEQUENCE   416 AA;  46649 MW;  24C329187B529F5B CRC64;
     MKTPFINREE LEAIVAEFPT PFHLYDEKGI REKARAVNQA FSWNKGFKEY FAVKATPTPA
     ILKILQEEGC GVDCSSYVEL LMSHKLDFLG SEIMFSSNNT PDKEYAYARE LGATINLDAF
     EDIEHLERVA GIPEIISCRY NPGGVFELGT DIMDNPGEAK FGMTKDQLFE AFAILKEKGA
     KTFGLHSFLA SNTVTHLYYP ELARQLFELA VEIKEKLGIW LDFINLSGGI GVNYRPDQEP
     NDIALIGEGV RKVYEEVLTS AGLGQVKIFT ELGRFMLAPH GALVTRVTHK KETYRTYLGV
     DASAVNLMRP AMYGAYHHIS NVTHPDGPAE AVDVVGSLCE NNDKFAVNRE LPHTEIGDLL
     VIHDTGAHGF SMGYQYNAKL RSAEILYTEE GKARQIRRAE RPEDYFATLY GFDFEE
//
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