ID Q8DWE7_STRMU Unreviewed; 466 AA.
AC Q8DWE7; Q1LZ69;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 27-MAR-2024, entry version 126.
DE SubName: Full=Constitutive fructose permease {ECO:0000313|EMBL:DAA01807.1};
DE SubName: Full=PTS system, fructose-specific IIBC component {ECO:0000313|EMBL:AAN57895.1};
GN Name=fruC {ECO:0000313|EMBL:DAA01807.1};
GN OrderedLocusNames=SMU_114 {ECO:0000313|EMBL:AAN57895.1};
OS Streptococcus mutans serotype c (strain ATCC 700610 / UA159).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=210007 {ECO:0000313|EMBL:AAN57895.1, ECO:0000313|Proteomes:UP000002512};
RN [1] {ECO:0000313|EMBL:DAA01807.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=UA159 {ECO:0000313|EMBL:DAA01807.1};
RX PubMed=11750824; DOI=10.1111/j.1574-6968.2001.tb10969.x;
RA Wen Z.T., Browngardt C., Burne R.A.;
RT "Characterization of two operons that encode components of fructose-
RT specific enzyme II of the sugar:phosphotransferase system of Streptococcus
RT mutans.";
RL FEMS Microbiol. Lett. 205:337-342(2001).
RN [2] {ECO:0000313|EMBL:AAN57895.1, ECO:0000313|Proteomes:UP000002512}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700610 / UA159 {ECO:0000313|Proteomes:UP000002512}, and
RC UA159 {ECO:0000313|EMBL:AAN57895.1};
RX PubMed=12397186; DOI=10.1073/pnas.172501299;
RA Ajdic D., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B.,
RA Primeaux C., Tian R., Kenton S., Jia H., Lin S., Qian Y., Li S., Zhu H.,
RA Najar F., Lai H., White J., Roe B.A., Ferretti J.J.;
RT "Genome sequence of Streptococcus mutans UA159, a cariogenic dental
RT pathogen.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:14434-14439(2002).
RN [3] {ECO:0000313|EMBL:AAN57895.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=UA159 {ECO:0000313|EMBL:AAN57895.1};
RA Ajdic D., McShan W.M., McLaughlin R.E., Savic G., Chang J., Carson M.B.,
RA Primeaux C., Tian R., Kenton S., Jia H., Lin S., Qian Y., Li S., Zhu H.,
RA Najar F., Lai H., White J., Roe B.A., Ferretti J.J.;
RL Submitted (SEP-2011) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AE014133; AAN57895.1; -; Genomic_DNA.
DR EMBL; BK000030; DAA01807.1; -; Genomic_DNA.
DR RefSeq; NP_720589.1; NC_004350.2.
DR RefSeq; WP_002263696.1; NC_004350.2.
DR AlphaFoldDB; Q8DWE7; -.
DR SMR; Q8DWE7; -.
DR STRING; 210007.SMU_114; -.
DR TCDB; 4.A.2.1.8; the pts fructose-mannitol (fru) family.
DR KEGG; smu:SMU_114; -.
DR PATRIC; fig|210007.7.peg.96; -.
DR eggNOG; COG1299; Bacteria.
DR eggNOG; COG1445; Bacteria.
DR HOGENOM; CLU_013155_4_2_9; -.
DR OrthoDB; 9782569at2; -.
DR BRENDA; 2.7.1.202; 14748.
DR Proteomes; UP000002512; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005351; F:carbohydrate:proton symporter activity; IEA:InterPro.
DR GO; GO:0022877; F:protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity; IEA:InterPro.
DR GO; GO:0009401; P:phosphoenolpyruvate-dependent sugar phosphotransferase system; IEA:UniProtKB-KW.
DR CDD; cd05569; PTS_IIB_fructose; 1.
DR Gene3D; 3.40.50.2300; -; 1.
DR InterPro; IPR036095; PTS_EIIB-like_sf.
DR InterPro; IPR013011; PTS_EIIB_2.
DR InterPro; IPR003501; PTS_EIIB_2/3.
DR InterPro; IPR013014; PTS_EIIC_2.
DR InterPro; IPR003353; PTS_IIB_fruc.
DR InterPro; IPR006327; PTS_IIC_fruc.
DR NCBIfam; TIGR00829; FRU; 1.
DR NCBIfam; TIGR01427; PTS_IIC_fructo; 1.
DR PANTHER; PTHR30505; FRUCTOSE-LIKE PERMEASE; 1.
DR PANTHER; PTHR30505:SF28; PTS SYSTEM 2-O-ALPHA-MANNOSYL-D-GLYCERATE-SPECIFIC EIIABC COMPONENT; 1.
DR Pfam; PF02302; PTS_IIB; 1.
DR SUPFAM; SSF52794; PTS system IIB component-like; 1.
DR PROSITE; PS51099; PTS_EIIB_TYPE_2; 1.
DR PROSITE; PS51104; PTS_EIIC_TYPE_2; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphotransferase system {ECO:0000256|ARBA:ARBA00022683};
KW Reference proteome {ECO:0000313|Proteomes:UP000002512};
KW Sugar transport {ECO:0000256|ARBA:ARBA00022597};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 141..161
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 181..198
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 210..238
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 258..276
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 297..316
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 336..359
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 397..415
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 435..456
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 6..101
FT /note="PTS EIIB type-2"
FT /evidence="ECO:0000259|PROSITE:PS51099"
FT DOMAIN 130..465
FT /note="PTS EIIC type-2"
FT /evidence="ECO:0000259|PROSITE:PS51104"
SQ SEQUENCE 466 AA; 48903 MW; 3C7244E497A95815 CRC64;
MSEFKLIAAT GCPTGIAHTF MAQEALEQAA KEKGVSIKVE THGQVGVENE LTPAEIAGAK
AVIIAADKDV QAERFAGKRV IEVSVADGIK KADQLIADAL AGKGQIKGGT KIESAELSSD
TEGESFGRQV YRHLMNGVSH MLPFVVAGGV LVAISFLFGI YSFDPKSEQY NWFAALLKTD
IGGVAMGVMT PILAAYIAES IAKRPGFVAG FVGGMMAVNG GSGFLGGIIA GFAAGYIVLG
LMKLFEKLPK SLDGLKAIFL YPVFGVFLTG MVMAVVNSPM AWVNKSLMAW LGAFENANPL
VLGVIVGCMC AFDMGGPVNK AAYVTGTALL AQGNTTFMAG VSAACIAPPL ITFVATTAFR
KYYDENDRNA GLANLILGST HITEGAIPFA AKDPLRMLPT FMLGSSIAAI LTYMWKVKVP
APHGGFLVLP VVTHAFLWVL AIAIGAIVAG IIMGFIQKSK YEKARG
//
