GenomeNet

Database: UniProt
Entry: Q8E1Q5_STRA5
LinkDB: Q8E1Q5_STRA5
Original site: Q8E1Q5_STRA5 
ID   Q8E1Q5_STRA5            Unreviewed;       750 AA.
AC   Q8E1Q5;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   24-JAN-2024, entry version 104.
DE   RecName: Full=peptidoglycan glycosyltransferase {ECO:0000256|ARBA:ARBA00012555};
DE            EC=2.4.1.129 {ECO:0000256|ARBA:ARBA00012555};
GN   Name=pbp1A {ECO:0000313|EMBL:AAM99205.1};
GN   OrderedLocusNames=SAG0298 {ECO:0000313|EMBL:AAM99205.1};
OS   Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R).
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=208435 {ECO:0000313|EMBL:AAM99205.1, ECO:0000313|Proteomes:UP000000821};
RN   [1] {ECO:0000313|EMBL:AAM99205.1, ECO:0000313|Proteomes:UP000000821}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-611 / 2603 V/R {ECO:0000313|Proteomes:UP000000821};
RX   PubMed=12200547; DOI=10.1073/pnas.182380799;
RA   Tettelin H., Masignani V., Cieslewicz M.J., Eisen J.A., Peterson S.,
RA   Wessels M.R., Paulsen I.T., Nelson K.E., Margarit I., Read T.D.,
RA   Madoff L.C., Wolf A.M., Beanan M.J., Brinkac L.M., Daugherty S.C.,
RA   DeBoy R.T., Durkin S., Kolonay J.F., Umayam L.A., Madupu R., Lewis M.R.,
RA   Radune D., Fedorova N.B., Scanlan D., Khouri H., Mulligan S., Carty H.A.,
RA   Cline R.T., Gill J., Scarselli M., Mora M., Iacobini E.T., Brettoni C.,
RA   Galli G., Mariani M., Vegni F., Maione D., Rinaudo D., Rappuoli R.,
RA   Telford J.L., Kasper D.L., Grandi G., Fraser C.M.;
RT   "Complete genome sequence and comparative genomic analysis of an emerging
RT   human pathogen, serotype V Streptococcus agalactiae.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:12391-12396(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-
CC         Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-
CC         (1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-
CC         cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-
CC         D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl
CC         diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H(+);
CC         Xref=Rhea:RHEA:23708, Rhea:RHEA-COMP:9602, Rhea:RHEA-COMP:9603,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:58405, ChEBI:CHEBI:60033,
CC         ChEBI:CHEBI:78435; EC=2.4.1.129;
CC         Evidence={ECO:0000256|ARBA:ARBA00023988};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AE009948; AAM99205.1; -; Genomic_DNA.
DR   RefSeq; NP_687333.1; NC_004116.1.
DR   RefSeq; WP_000628368.1; NC_004116.1.
DR   AlphaFoldDB; Q8E1Q5; -.
DR   STRING; 208435.SAG0298; -.
DR   KEGG; sag:SAG0298; -.
DR   PATRIC; fig|208435.3.peg.296; -.
DR   HOGENOM; CLU_006354_2_5_9; -.
DR   OMA; LAQMAMI; -.
DR   OrthoDB; 9766909at2; -.
DR   Proteomes; UP000000821; Chromosome.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   GO; GO:0008955; F:peptidoglycan glycosyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009002; F:serine-type D-Ala-D-Ala carboxypeptidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.3810.10; Biosynthetic peptidoglycan transglycosylase-like; 1.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 1.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR001264; Glyco_trans_51.
DR   InterPro; IPR023346; Lysozyme-like_dom_sf.
DR   InterPro; IPR036950; PBP_transglycosylase.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   NCBIfam; TIGR02074; PBP_1a_fam; 1.
DR   NCBIfam; NF038272; strep_PBP1A; 1.
DR   PANTHER; PTHR32282; BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATED; 1.
DR   PANTHER; PTHR32282:SF29; PENICILLIN-BINDING PROTEIN 1A/1B; 1.
DR   Pfam; PF00912; Transgly; 1.
DR   Pfam; PF00905; Transpeptidase; 1.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 1.
DR   SUPFAM; SSF53955; Lysozyme-like; 1.
PE   4: Predicted;
KW   Carboxypeptidase {ECO:0000256|ARBA:ARBA00022645};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW   Protease {ECO:0000256|ARBA:ARBA00022670};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000821};
KW   Secreted {ECO:0000256|ARBA:ARBA00022525};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..39
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          63..239
FT                   /note="Glycosyl transferase family 51"
FT                   /evidence="ECO:0000259|Pfam:PF00912"
FT   DOMAIN          335..628
FT                   /note="Penicillin-binding protein transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF00905"
FT   REGION          678..750
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        701..750
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   750 AA;  82573 MW;  80A29580608B2031 CRC64;
     MITIKKESVI KLLKYAFGII MGFIILAIVI GGLLFAYYVS RSPKLTDQAL KSVNSSLVYD
     GNNKLIADLG SEKRESVSAD SIPLNLVNAI TSIEDKRFFK HRGVDIYRIL GAAWHNLVSS
     NTQGGSTLDQ QLIKLAYFST NKSDQTLKRK SQEVWLALQM ERKYTKEEIL TFYINKVYMG
     NGNYGMRTTA KSYFGKDLKE LSIAQLALLA GIPQAPTQYD PYKNPESAQT RRNTVLQQMY
     QDKNISKKEY DQAVATPVTD GLKELKQKST YPKYMDNYLK QVISEVKQKT GKDIFTAGLK
     VYTNINTDAQ KQLYDIYNSD TYIAYPNNEL QIASTIMDAT NGKVIAQLGG RHQNENISFG
     TNQSVLTDRD WGSTMKPISA YAPAIDSGVY NSTGQSLNDS VYYWPGTSTQ LYDWDRQYMG
     WMSMQTAIQQ SRNVPAVRAL EAAGLDEAKS FLEKLGIYYP EMNYSNAISS NNSSSDAKYG
     ASSEKMAAAY SAFANGGTYY KPQYVNKIEF SDGTNDTYAA SGSRAMKETT AYMMTDMLKT
     VLTFGTGTKA AIPGVAQAGK TGTSNYTEDE LAKIEATTGI YNSAVGTMAP DENFVGYTSK
     YTMAIWTGYK NRLTPLYGSQ LDIATEVYRA MMSYLTGGYS ADWTMPEGLY RSGSYLYING
     TTTTGTYSSS VYKNIYQNSG QSSQSSSSTS SEKQKEDKNT ANDANSSSPQ VETPNNGNAT
     TPNNSNQTVP GTGHGNGNGN GNNNTVPNGN
//
DBGET integrated database retrieval system