ID Q8E589_STRA3 Unreviewed; 932 AA.
AC Q8E589;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 27-MAR-2024, entry version 110.
DE RecName: Full=Gram-positive cocci surface proteins LPxTG domain-containing protein {ECO:0000259|PROSITE:PS50847};
GN OrderedLocusNames=gbs1143 {ECO:0000313|EMBL:CAD46802.1};
OS Streptococcus agalactiae serotype III (strain NEM316).
OC Bacteria; Bacillota; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=211110 {ECO:0000313|EMBL:CAD46802.1, ECO:0000313|Proteomes:UP000000823};
RN [1] {ECO:0000313|EMBL:CAD46802.1, ECO:0000313|Proteomes:UP000000823}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEM316 {ECO:0000313|EMBL:CAD46802.1,
RC ECO:0000313|Proteomes:UP000000823};
RX PubMed=12354221; DOI=10.1046/j.1365-2958.2002.03126.x;
RA Glaser P., Rusniok C., Buchrieser C., Chevalier F., Frangeul L., Msadek T.,
RA Zouine M., Couve E., Lalioui L., Poyart C., Trieu-Cuot P., Kunst F.;
RT "Genome sequence of Streptococcus agalactiae, a pathogen causing invasive
RT neonatal disease.";
RL Mol. Microbiol. 45:1499-1513(2002).
RN [2] {ECO:0007829|PDB:4Z1P}
RP X-RAY CRYSTALLOGRAPHY (1.89 ANGSTROMS) OF 554-932.
RA Rego S., Race P.;
RT "BspA_C_mut.";
RL Submitted (MAR-2015) to the PDB data bank.
RN [3] {ECO:0007829|PDB:4Z23}
RP X-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS) OF 554-881.
RA Race P., Rego S.;
RT "BspA_C_WT.";
RL Submitted (MAR-2015) to the PDB data bank.
RN [4] {ECO:0007829|PDB:5DZ8, ECO:0007829|PDB:5DZ9}
RP X-RAY CRYSTALLOGRAPHY (1.89 ANGSTROMS) OF 554-881.
RX PubMed=27311712; DOI=10.1074/jbc.M116.726562;
RA Rego S., Heal T.J., Pidwill G.R., Till M., Robson A., Lamont R.J.,
RA Sessions R.B., Jenkinson H.F., Race P.R., Nobbs A.H.;
RT "Structural and Functional Analysis of Cell Wall-anchored Polypeptide
RT Adhesin BspA in Streptococcus agalactiae.";
RL J. Biol. Chem. 291:15985-16000(2016).
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DR EMBL; AL766849; CAD46802.1; -; Genomic_DNA.
DR RefSeq; WP_001088030.1; NC_004368.1.
DR PDB; 4Z1P; X-ray; 1.89 A; A=554-932.
DR PDB; 4Z23; X-ray; 2.45 A; A=554-881.
DR PDB; 5DZ8; X-ray; 2.41 A; A/B=285-451.
DR PDB; 5DZ9; X-ray; 1.89 A; A=554-881.
DR PDB; 5DZA; X-ray; 2.19 A; A=554-881.
DR PDBsum; 4Z1P; -.
DR PDBsum; 4Z23; -.
DR PDBsum; 5DZ8; -.
DR PDBsum; 5DZ9; -.
DR PDBsum; 5DZA; -.
DR AlphaFoldDB; Q8E589; -.
DR SMR; Q8E589; -.
DR KEGG; san:gbs1143; -.
DR eggNOG; COG3087; Bacteria.
DR HOGENOM; CLU_016456_0_0_9; -.
DR Proteomes; UP000000823; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.60.40.740; -; 2.
DR InterPro; IPR026345; Adh_isopep-form_adh_dom.
DR InterPro; IPR041324; AgI/II_N.
DR InterPro; IPR032300; Antigen_C.
DR InterPro; IPR041237; BspA_v.
DR InterPro; IPR021197; Cross-wall-target_lipo_motif.
DR InterPro; IPR019931; LPXTG_anchor.
DR NCBIfam; TIGR04228; isopep_sspB_C2; 1.
DR NCBIfam; TIGR01167; LPXTG_anchor; 1.
DR NCBIfam; TIGR03726; strep_RK_lipo; 1.
DR Pfam; PF18652; Adhesin_P1_N; 1.
DR Pfam; PF17998; AgI_II_C2; 1.
DR Pfam; PF16364; Antigen_C; 1.
DR Pfam; PF18220; BspA_v; 1.
DR Pfam; PF00746; Gram_pos_anchor; 1.
DR PROSITE; PS50847; GRAM_POS_ANCHORING; 1.
PE 1: Evidence at protein level;
KW 3D-structure {ECO:0007829|PDB:4Z1P, ECO:0007829|PDB:4Z23};
KW Cell wall {ECO:0000256|ARBA:ARBA00022512};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Peptidoglycan-anchor {ECO:0000256|ARBA:ARBA00023088};
KW Secreted {ECO:0000256|ARBA:ARBA00022512}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..39
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 40..932
FT /note="Gram-positive cocci surface proteins LPxTG domain-
FT containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004304725"
FT TRANSMEM 908..927
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 900..932
FT /note="Gram-positive cocci surface proteins LPxTG"
FT /evidence="ECO:0000259|PROSITE:PS50847"
FT REGION 138..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 459..482
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 881..900
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 166..184
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 932 AA; 101612 MW; 015D656E12803428 CRC64;
MNSQETKGHG FFRKSKAYGL VCGIALAGAF TLATSQVSAD QVTTQATTQT VTQNQAETVT
STQLDKAVDT AKKAAVAVTT TTAVNHATTT DAQADLANQT QAVKDVTAKA QANTQAIKDA
TAENAKIDAE NKAEAERVAK ANKAGQAEVD ARNKAGQAAV DARNKAKQQA QDDQKAKIDA
ENKAESQRVS QLNAQNKAKI DAENKDAQAK ADATNAQLQK DYQTKLANIK SVEAYNAGVR
QRNKDAQAKA DATNAQLQKD YQAKLALYNQ ALKAKAEADK QSINNVAFDI KAQAKGVDNA
EYGNSIMTAK TKPDGSFEFN HDMIDGVKTI GYGKLTGKVN HHYVANKDGS VTAFVDSVTL
YKYEYRNVAQ NAAVNQNIVF RVLTKDGRPI FEKAHNGNKT FAETLNKTLQ LNLKYELKPH
ASSGNVEVFK IHDDWVHDTH GSALVSYVNN NDAVPNVVIP EQPTPPKPEK VTPEAEKPVP
EKPVEPKLVT PVLKTYTPVK FIPREYKPVP STPETFTPEK FTPAQPKVKP HVSVPEKINY
KVAVHPVQIP KATPTKKVLD ENGQSINGKS VLPNATLDYV AKQNFSQYKG IKASAEAIAK
GFAFVDQPNE ALAELTVKSI KASNGDDVSS LLEMRHVLSK DTLDQKLQSL IKEAGISPVG
EFYMWTAKDP QAFYKAYVQK GLDITYNLSF KVKKEFTKGQ IKNGVAQIDF GNGYTGNIVV
NDLTTPEVHK DVLDKEDGKS INNGTVKLGD EVTYKLEGWV VPANRGYDLF EYKFVDHLQH
THDLYLKDKV VAKVAITLKD GTVIPKGTNL VQYTETVYNK ETGRYELAFK ADFLAQVSRS
SAFGADDFIV VKRIKAGDVY NTADFFVNGN KVKTETVVTH TPEKPKPVMP QKVTPKAPAL
PSTGEQGVSV LTVLGAALLS LLGLVGFKKR QQ
//
