ID ASSY_STRA3 Reviewed; 396 AA.
AC Q8E7N1;
DT 23-APR-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 01-MAY-2013, entry version 68.
DE RecName: Full=Argininosuccinate synthase;
DE EC=6.3.4.5;
DE AltName: Full=Citrulline--aspartate ligase;
GN Name=argG; OrderedLocusNames=gbs0123;
OS Streptococcus agalactiae serotype III (strain NEM316).
OC Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC Streptococcus.
OX NCBI_TaxID=211110;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NEM316;
RX PubMed=12354221; DOI=10.1046/j.1365-2958.2002.03126.x;
RA Glaser P., Rusniok C., Buchrieser C., Chevalier F., Frangeul L.,
RA Msadek T., Zouine M., Couve E., Lalioui L., Poyart C., Trieu-Cuot P.,
RA Kunst F.;
RT "Genome sequence of Streptococcus agalactiae, a pathogen causing
RT invasive neonatal disease.";
RL Mol. Microbiol. 45:1499-1513(2002).
CC -!- CATALYTIC ACTIVITY: ATP + L-citrulline + L-aspartate = AMP +
CC diphosphate + N(omega)-(L-arginino)succinate.
CC -!- PATHWAY: Amino-acid biosynthesis; L-arginine biosynthesis; L-
CC arginine from L-ornithine and carbamoyl phosphate: step 2/3.
CC -!- SUBUNIT: Homotetramer (By similarity).
CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC -!- SIMILARITY: Belongs to the argininosuccinate synthase family. Type
CC 1 subfamily.
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DR EMBL; AL766843; CAD45768.1; -; Genomic_DNA.
DR RefSeq; NP_734593.1; NC_004368.1.
DR ProteinModelPortal; Q8E7N1; -.
DR STRING; 211110.gbs0123; -.
DR EnsemblBacteria; CAD45768; CAD45768; CAD45768.
DR GeneID; 1031244; -.
DR KEGG; san:gbs0123; -.
DR PATRIC; 19635983; VBIStrAga3577_0123.
DR GenoList; gbs0123; -.
DR eggNOG; COG0137; -.
DR HOGENOM; HOG000230093; -.
DR KO; K01940; -.
DR OMA; NDQFRFE; -.
DR ProtClustDB; PRK00509; -.
DR UniPathway; UPA00068; UER00113.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004055; F:argininosuccinate synthase activity; IEA:HAMAP.
DR GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR GO; GO:0006526; P:arginine biosynthetic process; IEA:HAMAP.
DR Gene3D; 3.40.50.620; -; 1.
DR Gene3D; 3.90.1260.10; -; 1.
DR HAMAP; MF_00005; Arg_succ_synth_type1; 1; -.
DR InterPro; IPR001518; Arginosuc_synth.
DR InterPro; IPR018223; Arginosuc_synth_CS.
DR InterPro; IPR023434; Arginosuc_synth_type_1_subfam.
DR InterPro; IPR024074; AS_cat/multimer_dom_body.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR PANTHER; PTHR11587; PTHR11587; 1.
DR Pfam; PF00764; Arginosuc_synth; 1.
DR TIGRFAMs; TIGR00032; argG; 1.
DR PROSITE; PS00564; ARGININOSUCCIN_SYN_1; 1.
DR PROSITE; PS00565; ARGININOSUCCIN_SYN_2; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis; Arginine biosynthesis; ATP-binding;
KW Complete proteome; Cytoplasm; Ligase; Nucleotide-binding.
FT CHAIN 1 396 Argininosuccinate synthase.
FT /FTId=PRO_0000148643.
FT NP_BIND 9 17 ATP (By similarity).
FT BINDING 85 85 Citrulline (By similarity).
FT BINDING 115 115 ATP; via amide nitrogen (By similarity).
FT BINDING 117 117 Aspartate (By similarity).
FT BINDING 121 121 Aspartate (By similarity).
FT BINDING 121 121 Citrulline (By similarity).
FT BINDING 122 122 Aspartate (By similarity).
FT BINDING 125 125 Citrulline (By similarity).
FT BINDING 173 173 Citrulline (By similarity).
FT BINDING 258 258 Citrulline (By similarity).
FT BINDING 270 270 Citrulline (By similarity).
SQ SEQUENCE 396 AA; 43725 MW; 31DB024B0785AC52 CRC64;
MGKEKLILAY SGGLDTSVAI AWLKKDYDVI AVCMDVGEGK DLDFIHDKAL TIGAIESYIL
DVKDEFAEHF VLPALQAHAM YEQKYPLVSA LSRPIIAQKL VEMAHQTGAT TIAHGCTGKG
NDQVRFEVAI AALDPELKVI APVREWKWHR EEEITFAKAN GVPIPADLDN PYSIDQNLWG
RANECGVLEN PWNQAPEEAF GITKSPEEAP DCAEYIDITF QNGKPIAINN QEMTLADLIL
SLNEIAGKHG IGRIDHVENR LVGIKSREIY ECPAAMVLLA AHKEIEDLTL VREVSHFKPI
LENELSNLIY NALWFSPATK AIIAYVKETQ KVVNGTTKVK LYKGSAKVVA RHSSNSLYDE
NLATYTAADN FDQDAAVGFI KLWGLPTQVN AQVNKG
//
