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Database: UniProt
Entry: Q8EX49_MYCPE
LinkDB: Q8EX49_MYCPE
Original site: Q8EX49_MYCPE 
ID   Q8EX49_MYCPE            Unreviewed;       452 AA.
AC   Q8EX49;
DT   01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT   01-MAR-2003, sequence version 1.
DT   25-OCT-2017, entry version 125.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|RuleBase:RU000577};
GN   OrderedLocusNames=MYPE10 {ECO:0000313|EMBL:BAC43791.1};
OS   Mycoplasma penetrans (strain HF-2).
OC   Bacteria; Tenericutes; Mollicutes; Mycoplasmataceae; Mycoplasma.
OX   NCBI_TaxID=272633 {ECO:0000313|EMBL:BAC43791.1, ECO:0000313|Proteomes:UP000002522};
RN   [1] {ECO:0000313|EMBL:BAC43791.1, ECO:0000313|Proteomes:UP000002522}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HF-2 {ECO:0000313|EMBL:BAC43791.1,
RC   ECO:0000313|Proteomes:UP000002522};
RX   PubMed=12466555; DOI=10.1093/nar/gkf667;
RA   Sasaki Y., Ishikawa J., Yamashita A., Oshima K., Kenri T., Furuya K.,
RA   Yoshino C., Horino A., Shiba T., Sasaki T., Hattori M.;
RT   "The complete genomic sequence of Mycoplasma penetrans, an
RT   intracellular bacterial pathogen in humans.";
RL   Nucleic Acids Res. 30:5293-5300(2002).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|RuleBase:RU000577,
CC       ECO:0000256|SAAS:SAAS00735475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family.
CC       {ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; BA000026; BAC43791.1; -; Genomic_DNA.
DR   RefSeq; WP_011076827.1; NC_004432.1.
DR   ProteinModelPortal; Q8EX49; -.
DR   STRING; 272633.MYPE10; -.
DR   EnsemblBacteria; BAC43791; BAC43791; BAC43791.
DR   KEGG; mpe:MYPE10; -.
DR   eggNOG; ENOG4105CI4; Bacteria.
DR   eggNOG; COG0593; LUCA.
DR   KO; K02313; -.
DR   OMA; REFNPLF; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000002522; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:InterPro.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:InterPro.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:InterPro.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000002522};
KW   Cytoplasm {ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|RuleBase:RU004227,
KW   ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU000577,
KW   ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002522}.
FT   DOMAIN      141    276       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      362    431       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
SQ   SEQUENCE   452 AA;  52977 MW;  A853FC934F25F0E2 CRC64;
     MFTLAQIKKK YLIIKKEIEK EFQNENFYNN YVLDSSIFKI KDENVYILVK NDFVKEVFTN
     EYKEIFEEYF SIKMNSNLNV FFITKEEKDI NKELPTIEEK PKTLEINPTL DSRFTFENYT
     IGMFNKNAFK AASLFLEENN NWKTLLIYGS TGLGKTHLLH AVGNKFVQLF PQKNLMYIQT
     EDFLEKIYKA ISEGGTKVEE FKNSFDNVDL LLIDDIQFLN NKEKLNEIFF NIFNRLNSKN
     KYIVMTSDKL PTSLKIDDRM ISRFNSGLSI KINKPDTESI KKIIIENIKK SRIKNPFSNL
     AIEFIALRFN SDIRTLEGVL NKIYFHLLDN VDPNEIINEE KIRSIIESDS DYEIVSNLVQ
     INPDIIIESI CLGYGVDKKS VISKKRNKQF SFVRKVCMYV LREKINLSYN EIGSFFSNRN
     HATVLEAIKD VETKVKSDED LKAFLDNIMS KF
//
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