ID Q8EZ60_LEPIN Unreviewed; 1135 AA.
AC Q8EZ60;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 27-MAR-2024, entry version 106.
DE SubName: Full=Cholesterol oxidase {ECO:0000313|EMBL:AAN51196.1};
GN OrderedLocusNames=LA_3998 {ECO:0000313|EMBL:AAN51196.1};
OS Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain
OS 56601).
OC Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC Leptospira.
OX NCBI_TaxID=189518 {ECO:0000313|EMBL:AAN51196.1, ECO:0000313|Proteomes:UP000001408};
RN [1] {ECO:0000313|EMBL:AAN51196.1, ECO:0000313|Proteomes:UP000001408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=56601 {ECO:0000313|EMBL:AAN51196.1,
RC ECO:0000313|Proteomes:UP000001408};
RX PubMed=12712204; DOI=10.1038/nature01597;
RA Ren S.X., Fu G., Jiang X.G., Zeng R., Miao Y.G., Xu H., Zhang Y.X.,
RA Xiong H., Lu G., Lu L.F., Jiang H.Q., Jia J., Tu Y.F., Jiang J.X., Gu W.Y.,
RA Zhang Y.Q., Cai Z., Sheng H.H., Yin H.F., Zhang Y., Zhu G.F., Wan M.,
RA Huang H.L., Qian Z., Wang S.Y., Ma W., Yao Z.J., Shen Y., Qiang B.Q.,
RA Xia Q.C., Guo X.K., Danchin A., Saint Girons I., Somerville R.L., Wen Y.M.,
RA Shi M.H., Chen Z., Xu J.G., Zhao G.P.;
RT "Unique physiological and pathogenic features of Leptospira interrogans
RT revealed by whole-genome sequencing.";
RL Nature 422:888-893(2003).
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DR EMBL; AE010300; AAN51196.1; -; Genomic_DNA.
DR RefSeq; NP_714178.1; NC_004342.2.
DR RefSeq; WP_000615086.1; NC_004342.2.
DR AlphaFoldDB; Q8EZ60; -.
DR STRING; 189518.LA_3998; -.
DR ESTHER; lepin-LA3998; 6_AlphaBeta_hydrolase.
DR PaxDb; 189518-LA_3998; -.
DR EnsemblBacteria; AAN51196; AAN51196; LA_3998.
DR KEGG; lil:LA_3998; -.
DR PATRIC; fig|189518.3.peg.3966; -.
DR HOGENOM; CLU_002483_0_0_12; -.
DR InParanoid; Q8EZ60; -.
DR OrthoDB; 9787779at2; -.
DR Proteomes; UP000001408; Chromosome I.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0016614; F:oxidoreductase activity, acting on CH-OH group of donors; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 3.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR000073; AB_hydrolase_1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR000172; GMC_OxRdtase_N.
DR InterPro; IPR007867; GMC_OxRtase_C.
DR PANTHER; PTHR47470; CHOLESTEROL OXIDASE; 1.
DR PANTHER; PTHR47470:SF1; FAD-DEPENDENT OXIDOREDUCTASE 2 FAD BINDING DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00561; Abhydrolase_1; 1.
DR Pfam; PF05199; GMC_oxred_C; 1.
DR Pfam; PF00732; GMC_oxred_N; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001408}.
FT DOMAIN 70..289
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00732"
FT DOMAIN 483..548
FT /note="Glucose-methanol-choline oxidoreductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF05199"
FT DOMAIN 826..1117
FT /note="AB hydrolase-1"
FT /evidence="ECO:0000259|Pfam:PF00561"
SQ SEQUENCE 1135 AA; 126302 MW; 30E4DB77CC9644FF CRC64;
MIQKISQPIE KIKNQYEAVV IGSGYGGAIA ASRLSRAGIE VCLLERGKEI RPGEFPNKEI
SALEEVQANY EDKQIGPKNG LFDFHFNKDI NVLVGCGLGG TSLINANVSL RAVPEVFQDP
AWPKNIREEA SKHGFDPYYS LAEEMLRPNP IPNQYRNLAK HQALKTSASF LKKEFYPTPI
NVTFQSKINH VGVKQEACTN CGDCVTGCNV SSKNTTLMNY LPDAANFGAQ IFTEVKVSYI
EKQEDSWLIH FVPLGLDREK FSKDELFIRA KTVILSAGSL GSTEILLRSK EKGLNVSDSV
GVRFSGNGDM LGFSYNGNTT INGIGFGSKK TNTEVGPCIT GVIDTRKGAS LNEGMIIEEG
SIPGAIRGQL PEIFAIASKL TGVKTKKGFF QWVIEKIRIF LSFILGSYRG AVKNTQTYLV
MAHDGNDGKM FLQNDRLRIS WPNVGKKPIF EKISTILKEA TVPLQGTYIK NPVWNRLTDQ
DLISVHPLGG CPMGDDASTS AVNENCQVYS GKSGKETYNG LYIMDGSVIP RSLGVNPLLT
ICAISERACE KLISQKGLTI NYNLPSYPKH TNVPDEKTLG IEFTECMKGF FSTQSKEDTE
RGYQIGKDEG SSIEFLLTIR SENLNEMISN PDHKATLFGT VKAPVLSKDV ITVTNGEFLL
FISREDKVET RNMVYRMILN TEEGKKYLFV GAKWIQNDGL TNIWRDTSTL FTTIYEGETE
NSPVLGKGIL HILPEDFAKQ MTTMKVIHAK SLIDTIQGLT KFGSFFAGAL YDVYGGVASS
IVPWDKDARP RTKRPLRVSS PEVHFFKAED GANLRLLRYK GGNKGPVLLS PGLGVSSLIF
SIDTIDTNLL EYLFENQYDV WLFDYRTSIA LPSAPLPNTG DAIATKDYPA AVNKVRELTK
VDKIQVVAHC FGATTFTMAL LSGLEGVRSV VLSQISADVE VPTSMDIKVG FHTAEILDAL
GIKDMTAYTS NHDDWLDRFF NSVLALQPQS LFSHDVNPVS RRISFLYGSL YILENLNEET
YRYGLGEMFG VSNIKAFEHL SKMIRAHKVV NSEGQDVYVP HLDRLNLPIT FIHGAQNRCY
LPESTETTYK KLIDRFNPNQ YRRHVIPDYG HIDCIFGKDA YKDVYPFILQ SLNRY
//
