ID Q8F0D1_LEPIN Unreviewed; 515 AA.
AC Q8F0D1;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 27-MAR-2024, entry version 135.
DE RecName: Full=Putative glycerol kinase 5 {ECO:0000256|ARBA:ARBA00013787};
DE AltName: Full=ATP:glycerol 3-phosphotransferase {ECO:0000256|ARBA:ARBA00043149};
DE AltName: Full=ATP:glycerol 3-phosphotransferase 5 {ECO:0000256|ARBA:ARBA00033026};
GN Name=glpK {ECO:0000313|EMBL:AAN50763.1};
GN OrderedLocusNames=LA_3565 {ECO:0000313|EMBL:AAN50763.1};
OS Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain
OS 56601).
OC Bacteria; Spirochaetota; Spirochaetia; Leptospirales; Leptospiraceae;
OC Leptospira.
OX NCBI_TaxID=189518 {ECO:0000313|EMBL:AAN50763.1, ECO:0000313|Proteomes:UP000001408};
RN [1] {ECO:0000313|EMBL:AAN50763.1, ECO:0000313|Proteomes:UP000001408}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=56601 {ECO:0000313|EMBL:AAN50763.1,
RC ECO:0000313|Proteomes:UP000001408};
RX PubMed=12712204; DOI=10.1038/nature01597;
RA Ren S.X., Fu G., Jiang X.G., Zeng R., Miao Y.G., Xu H., Zhang Y.X.,
RA Xiong H., Lu G., Lu L.F., Jiang H.Q., Jia J., Tu Y.F., Jiang J.X., Gu W.Y.,
RA Zhang Y.Q., Cai Z., Sheng H.H., Yin H.F., Zhang Y., Zhu G.F., Wan M.,
RA Huang H.L., Qian Z., Wang S.Y., Ma W., Yao Z.J., Shen Y., Qiang B.Q.,
RA Xia Q.C., Guo X.K., Danchin A., Saint Girons I., Somerville R.L., Wen Y.M.,
RA Shi M.H., Chen Z., Xu J.G., Zhao G.P.;
RT "Unique physiological and pathogenic features of Leptospira interrogans
RT revealed by whole-genome sequencing.";
RL Nature 422:888-893(2003).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + glycerol = ADP + H(+) + sn-glycerol 3-phosphate;
CC Xref=Rhea:RHEA:21644, ChEBI:CHEBI:15378, ChEBI:CHEBI:17754,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:57597, ChEBI:CHEBI:456216;
CC EC=2.7.1.30; Evidence={ECO:0000256|ARBA:ARBA00001373};
CC -!- SIMILARITY: Belongs to the FGGY kinase family.
CC {ECO:0000256|ARBA:ARBA00009156, ECO:0000256|RuleBase:RU003733}.
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DR EMBL; AE010300; AAN50763.1; -; Genomic_DNA.
DR RefSeq; NP_713745.1; NC_004342.2.
DR RefSeq; WP_000013893.1; NC_004342.2.
DR AlphaFoldDB; Q8F0D1; -.
DR STRING; 189518.LA_3565; -.
DR PaxDb; 189518-LA_3565; -.
DR EnsemblBacteria; AAN50763; AAN50763; LA_3565.
DR GeneID; 61143973; -.
DR KEGG; lil:LA_3565; -.
DR PATRIC; fig|189518.3.peg.3534; -.
DR HOGENOM; CLU_009281_2_3_12; -.
DR InParanoid; Q8F0D1; -.
DR OrthoDB; 366323at2; -.
DR Proteomes; UP000001408; Chromosome I.
DR GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR GO; GO:0004370; F:glycerol kinase activity; IBA:GO_Central.
DR GO; GO:0019563; P:glycerol catabolic process; IBA:GO_Central.
DR GO; GO:0016310; P:phosphorylation; IBA:GO_Central.
DR CDD; cd07793; FGGY_GK5_metazoa; 1.
DR Gene3D; 3.30.420.40; -; 2.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR000577; Carb_kinase_FGGY.
DR InterPro; IPR018483; Carb_kinase_FGGY_CS.
DR InterPro; IPR018485; FGGY_C.
DR InterPro; IPR018484; FGGY_N.
DR InterPro; IPR037444; GK5_FGGY.
DR PANTHER; PTHR10196:SF69; GLYCEROL KINASE; 1.
DR PANTHER; PTHR10196; SUGAR KINASE; 1.
DR Pfam; PF02782; FGGY_C; 1.
DR Pfam; PF00370; FGGY_N; 1.
DR PIRSF; PIRSF000538; GlpK; 1.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR PROSITE; PS00445; FGGY_KINASES_2; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|RuleBase:RU003733, ECO:0000313|EMBL:AAN50763.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000001408};
KW Transferase {ECO:0000256|RuleBase:RU003733}.
FT DOMAIN 8..270
FT /note="Carbohydrate kinase FGGY N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00370"
FT DOMAIN 281..468
FT /note="Carbohydrate kinase FGGY C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02782"
SQ SEQUENCE 515 AA; 57152 MW; A9FF46654E434403 CRC64;
MANSQGKYVL SIDSGGSGIR AFLLDRKGNI VERQYEKTPP NIPEAGALEH DPEILWKALL
SLLKKIQKNQ QIVKEIIALG ICNQRGSFLL WEKSTGKPLT PLISWADVRS HKIAEAMNRN
LIWTIIRVVS TFVGRLTNHP MMIATSMLRF TTDHATCRLK WILDKNPDLK QRCKKGEVLF
GTLDTWFIYK LTGQKQHLTD SSNAVATGMF NPFQLIWNQP ILSIFGIPSN LFPEVKDSNG
DFGHTLPEYL GGHSIPIRAS IGDQMAALFG HCCFERGEVK ISQGSGAFVD INIGPKAKLS
KRGLFPMIAW RIDGNTTYML EGYVATAGTL IDWLGQGIGL SDTPKVLNEL AAQSEDTEGV
VFIPTPTGAR FPYFNPRAKA SVIGLSLASH RRHVARAVLE GISLSLYEIL EGIQRDTKVE
IKDIKVDGGV SQSDILLQCL SDFSNVRVNR SPEPDMTATG TAYLAGLAVG FWKNLDELKN
LQKGYKSFEP KMNPTKRVQK IQRWKKAVTA TLSIE
//
