ID Q8G3K5_BIFLO Unreviewed; 1712 AA.
AC Q8G3K5;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 27-MAR-2024, entry version 94.
DE RecName: Full=Activase {ECO:0008006|Google:ProtNLM};
GN OrderedLocusNames=BL1754 {ECO:0000313|EMBL:AAN25537.1};
OS Bifidobacterium longum (strain NCC 2705).
OC Bacteria; Actinomycetota; Actinomycetes; Bifidobacteriales;
OC Bifidobacteriaceae; Bifidobacterium.
OX NCBI_TaxID=206672 {ECO:0000313|EMBL:AAN25537.1, ECO:0000313|Proteomes:UP000000439};
RN [1] {ECO:0000313|EMBL:AAN25537.1, ECO:0000313|Proteomes:UP000000439}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCC 2705 {ECO:0000313|Proteomes:UP000000439};
RX PubMed=12381787; DOI=10.1073/pnas.212527599;
RA Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G.,
RA Zwahlen M.C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F.;
RT "The genome sequence of Bifidobacterium longum reflects its adaptation to
RT the human gastrointestinal tract.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002).
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC Evidence={ECO:0000256|ARBA:ARBA00001966};
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DR EMBL; AE014295; AAN25537.1; -; Genomic_DNA.
DR RefSeq; NP_696901.1; NC_004307.2.
DR RefSeq; WP_011068820.1; NC_004307.2.
DR STRING; 206672.BL1754; -.
DR EnsemblBacteria; AAN25537; AAN25537; BL1754.
DR KEGG; blo:BL1754; -.
DR PATRIC; fig|206672.9.peg.1809; -.
DR HOGENOM; CLU_002393_1_0_11; -.
DR OrthoDB; 9177882at2; -.
DR PhylomeDB; Q8G3K5; -.
DR Proteomes; UP000000439; Chromosome.
DR GO; GO:0051536; F:iron-sulfur cluster binding; IEA:UniProtKB-KW.
DR Gene3D; 3.30.420.40; -; 4.
DR InterPro; IPR002731; ATPase_BadF.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR018709; CoA_activase_DUF2229.
DR InterPro; IPR008275; CoA_E_activase_dom.
DR NCBIfam; TIGR00241; CoA_E_activ; 1.
DR PANTHER; PTHR32329:SF4; ACTIVATOR OF 2-HYDROXYACYL-COA DEHYDRATASE-RELATED; 1.
DR PANTHER; PTHR32329; BIFUNCTIONAL PROTEIN [INCLUDES 2-HYDROXYACYL-COA DEHYDRATASE (N-TER) AND ITS ACTIVATOR DOMAIN (C_TERM)-RELATED; 1.
DR Pfam; PF01869; BcrAD_BadFG; 2.
DR Pfam; PF09989; DUF2229; 1.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
PE 4: Predicted;
KW Iron {ECO:0000256|ARBA:ARBA00023014};
KW Iron-sulfur {ECO:0000256|ARBA:ARBA00023014};
KW Metal-binding {ECO:0000256|ARBA:ARBA00023014};
KW Reference proteome {ECO:0000313|Proteomes:UP000000439}.
FT DOMAIN 21..279
FT /note="ATPase BadF/BadG/BcrA/BcrD type"
FT /evidence="ECO:0000259|Pfam:PF01869"
FT DOMAIN 351..605
FT /note="ATPase BadF/BadG/BcrA/BcrD type"
FT /evidence="ECO:0000259|Pfam:PF01869"
FT DOMAIN 746..964
FT /note="DUF2229"
FT /evidence="ECO:0000259|Pfam:PF09989"
FT REGION 1101..1138
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1173..1208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1244..1267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1247..1267
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1712 AA; 186030 MW; 4C255B692D5A8C82 CRC64;
MVDIATDASL KPASHPKPLR VGLDIGSTTV KAVVLDQSDS LGDTLFSDYR RHHANVRATV
AGLLVDIHKK LVDLGRGDEP IRLSITGSGG LALADNLHVP FIQEVIAETE AIDKEYPQAD
VIIELGGEDA KITYLKPTPE QRMNGSCAGG TGAFIDQMST LLDTDAAGLN EMAKSYENLY
PIASRCGVFA KTDLQPLIND GAAKPDLAAS IFTAVATQTI AGLASGRPIH GTVIFLGGPL
FFMSELRAAF QRALEGKVDE FIVPTDAHLY VAYGSALQAD TDSDDQGHHF EAYTCDEILK
RLDELKNLPS NTPTMPPLFP TEADREDFNK RHHKEHIHIG TLEGAHGPHF LGIDAGSTTI
KATLVNDDRE IVWSSYANNE GSPLTAAINI VKKIQSELPE GAWIARSCAT GYGEGLITTG
LHLDEGVVET MAHYRGAEMV SPGVTAVIDI GGQDMKYLAI TDGVIDSIAV NEACSSGCGS
FLQTFAMSMG LTIQEFTQKA LASTHPVDLG SRCTVFMNSS VKQAQKEGAS IEDIAAGLCY
SVVRNALYKV IKLRDSGELG DTVVVQGGTF LNDAVLRAFE LLTEREVTRP NIAGLMGAFG
AALTARMHYE DIADDDNAHV GADGRSVDAA AAEESAAGDE PNAAAHAGEI VVDGVRHTVS
SILTGEALNE MSMTTERDVC KLCQNHCKLT ITTFSDGSRF VTGNRCERGG DAKKKRSDRP
NLYDYKYKRC FAYRRLTDKN ATRGEIGIPR ALNMYENYPF WFTLLTSLGF KVMISGRSSH
ELFETGIESI ASENICYPAK LVHGHIKWLL NKGMKTIFYP CVSYEDNLVP NTDNHYNCPV
VANYPLVVGA NMPELRDPDV RYMHPYFNLA NHELMVDRIV EEFAWASVSR EEAETAVKAA
YAEDKVFKHD VQQEGLKALA YMKEHDCRGI VLAGRPYHID PEINHGIPET ICALGMVVLS
EDSICELQPG EKLDLTDFLS EGEEDPRKKN ANGFRHVDDR KVTVNRMPLR VTNQWAYHSR
LYAAAHFVAS YPGLELVQLN SFGCGLDAIT TDQVAEILAD KADVYTLLKI DEVSNLGAAK
IRLRSLKAAV EEREANKARM AKAALATSDE SGSAESDAPR NAAHAAAQAA ARKAQEQAES
DLATAQAALA EAQAAVAAAE AKVKAADRPV DAADAGSDAA APANAPKSTG FRKTGSKAPT
PGRQVLLDAT MAANPKLTKA MRDASKRAAK RDIADVRLAA LGDGTTNDAA NAKSKSAKSK
SGHNNATMSR YAHREKFVKD MKKDYTIVAP QMSPIHFSLV ESVIRSGGYK FDILKHASRE
DVETGLKYVN NDACYPAIMV IGQLIDAILE GKYDPDKVCL AITQTGGMCR ATNYFGLIRK
ALIDAGYPQI PVIAISTQGL EDNPGFKVTP ALLHRTVKAL ILGDLLMKCL YRVRPYEVEK
GAANRLYEQW DVIVREALEH HGFSKTAAKT PWLKRRYLPY PVLAREIVKS FDALPLKDVP
RKVRVGVVGE ILVKYQPDAN NHVVDVIESQ DCEAVVPGIM EFMTTRPYIT DWNEKYLGTG
GNKTLYALMR WSLDRYNAPI KAAIATSHGK FKQDDPMPEL VEKAAEVTSI GVQAGEGWLL
TAEILELIEQ GCPNVICAQP FACLPNHVTG RGMFGKIRRL HPEANIVSID YDPGASEANQ
LNRIKLMIAA AKKAHNAKFA EAGEPQGFTS AD
//
