ID Q8G576_BIFLO Unreviewed; 554 AA.
AC Q8G576;
DT 01-MAR-2003, integrated into UniProtKB/TrEMBL.
DT 01-MAR-2003, sequence version 1.
DT 27-MAR-2024, entry version 128.
DE SubName: Full=Probable multiple substrate aminotransferase (MsaT) containing domain of GntR family {ECO:0000313|EMBL:AAN24949.1};
GN OrderedLocusNames=BL1144 {ECO:0000313|EMBL:AAN24949.1};
OS Bifidobacterium longum (strain NCC 2705).
OC Bacteria; Actinomycetota; Actinomycetes; Bifidobacteriales;
OC Bifidobacteriaceae; Bifidobacterium.
OX NCBI_TaxID=206672 {ECO:0000313|EMBL:AAN24949.1, ECO:0000313|Proteomes:UP000000439};
RN [1] {ECO:0000313|EMBL:AAN24949.1, ECO:0000313|Proteomes:UP000000439}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCC 2705 {ECO:0000313|Proteomes:UP000000439};
RX PubMed=12381787; DOI=10.1073/pnas.212527599;
RA Schell M.A., Karmirantzou M., Snel B., Vilanova D., Berger B., Pessi G.,
RA Zwahlen M.C., Desiere F., Bork P., Delley M., Pridmore R.D., Arigoni F.;
RT "The genome sequence of Bifidobacterium longum reflects its adaptation to
RT the human gastrointestinal tract.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:14422-14427(2002).
CC -!- SIMILARITY: In the C-terminal section; belongs to the class-I
CC pyridoxal-phosphate-dependent aminotransferase family.
CC {ECO:0000256|ARBA:ARBA00005384}.
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DR EMBL; AE014295; AAN24949.1; -; Genomic_DNA.
DR RefSeq; NP_696313.1; NC_004307.2.
DR RefSeq; WP_007056415.1; NC_004307.2.
DR AlphaFoldDB; Q8G576; -.
DR STRING; 206672.BL1144; -.
DR EnsemblBacteria; AAN24949; AAN24949; BL1144.
DR KEGG; blo:BL1144; -.
DR PATRIC; fig|206672.9.peg.854; -.
DR HOGENOM; CLU_017584_0_0_11; -.
DR OrthoDB; 199743at2; -.
DR PhylomeDB; Q8G576; -.
DR Proteomes; UP000000439; Chromosome.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0008483; F:transaminase activity; IEA:UniProtKB-KW.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR CDD; cd00609; AAT_like; 1.
DR CDD; cd07377; WHTH_GntR; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR004839; Aminotransferase_I/II.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR InterPro; IPR000524; Tscrpt_reg_HTH_GntR.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR46577; HTH-TYPE TRANSCRIPTIONAL REGULATORY PROTEIN GABR; 1.
DR PANTHER; PTHR46577:SF1; HTH-TYPE TRANSCRIPTIONAL REGULATORY PROTEIN GABR; 1.
DR Pfam; PF00155; Aminotran_1_2; 1.
DR Pfam; PF00392; GntR; 1.
DR PRINTS; PR00035; HTHGNTR.
DR SMART; SM00345; HTH_GNTR; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50949; HTH_GNTR; 1.
PE 3: Inferred from homology;
KW Aminotransferase {ECO:0000313|EMBL:AAN24949.1};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898};
KW Reference proteome {ECO:0000313|Proteomes:UP000000439};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transferase {ECO:0000313|EMBL:AAN24949.1}.
FT DOMAIN 11..79
FT /note="HTH gntR-type"
FT /evidence="ECO:0000259|PROSITE:PS50949"
FT REGION 101..153
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..142
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 554 AA; 61406 MW; 4B8AE6E7130FA1ED CRC64;
MQLELNRRSK VPMYRQLAAE LREQIVSGAM AEGYRLPPER ELSSRLEVNR TTVLQAYQQL
KDEGLIASKV GKGTFVLPAA SASRTSHTSN SDFGNAITRT TRSSAEMGTS QASSSGDVER
ATSTDFLTTD QGSSSAAVHT IRESRSVQGP EPTVVRPPWS VLFSDYSNRF TYHDIASAER
AQRGDTIIDF ATGSPNPADI PDDLLRKVSI EAFESREFDG QPESPIEGFE ELRALLAEHM
RARGVQCGVR NVMVLSGSEQ GIDLIVRAFI NPGDCVLVEQ STFFPALQTF RSADARIIGV
PVDEHGMRTD LLDGYCARFR PKLIYTVPTF QNPTGTTLSP ERRSELIDVA RRYQCLIVED
DAYGDLWYGG ESSDAHRPIP LKGMENAGYV MYLSTFSKTV TSGLRTGWVV ADPHVINRLA
ALRRMVDQHT STSSQRICLE LLKEGRIAEH LRGLIKAYRI RRDAAIAALE QYAPDEVYWT
MPAGGYYIWV SLPDGVRSLD VLESCRSQGV TFMPGSVFDV DEMDDSHIRL NFVRPDAADI
DTGIRIIGET IAQM
//
